Multiple primary tumors in the rabbit

Greene, Harry S. N.; Strauss, John S.

doi:10.1002/1097-0142(194907)2:4<673::aid-cncr2820020414>3.0.co;2-j

Cited by 60 publications

(39 citation statements)

References 6 publications

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“…To date, large studies on rabbit neoplasia were derived from laboratory animals and predominately contained data on young and juvenile animals. 10,31,48 The studies focused on uterine and mammary tumors and only described a few individual skin tumors. 10,13,14,48 A total of 24 different types of skin tumors and tumorlike lesions were diagnosed in this survey.…”

Section: Discussionmentioning

confidence: 99%

“…10,31,48 The studies focused on uterine and mammary tumors and only described a few individual skin tumors. 10,13,14,48 A total of 24 different types of skin tumors and tumorlike lesions were diagnosed in this survey. The three types most commonly diagnosed were trichoblastoma (59), collagenous hamartoma (27), and Shope fibroma (19), and these comprised more than half of the tumors.…”

Section: Discussionmentioning

confidence: 99%

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Cutaneous Neoplasms in Pet Rabbits: A Retrospective Study

et al. 2007

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Abstract. Over a 16-year period, 190 tumors and tumorlike lesions from 179 pet rabbits were submitted for histopathologic examination. A total of 23 different tumor types and 1 tumorlike lesion were diagnosed. The most common diagnoses were trichoblastoma, collagenous hamartoma, and Shope fibroma. Viral-induced tumors were Shope fibroma (19) and Shope papilloma (2). Common nonviral epithelial tumors included trichoblastoma (59), squamous cell carcinoma (5), squamous papilloma (4), trichoepithelioma (3), and apocrine carcinoma (3). Common mesenchymal tumors were lipoma (10), liposarcoma (3), myxosarcoma (9), malignant peripheral nerve sheath tumor (8), fibrosarcoma (7), and leiomyosarcoma (4). Malignant melanoma was diagnosed in 8 rabbits. Collagenous hamartomas were diagnosed in 26 rabbits. Mesenchymal proliferations occurred significantly more often in male rabbits than in females. Collagenous hamartomas and myxosarcomas occurred exclusively in male animals, and 3 rabbits had multiple collagenous hamartomas. Immunohistochemistry was applied in cases in which a definite diagnosis could not be reached on hematoxylin and eosin slides. Follow-up information was received in 19 cases. Carcinomas recurred (2 of 3) or metastasized (1 of 3), whereas sarcomas frequently recurred (7 of 12). One malignant melanoma (1 of 3) and one poorly differentiated round cell neoplasm recurred (1 of 1). This is the first comprehensive retrospective analysis on skin neoplasia in pet rabbits.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cutaneous Neoplasms in Pet Rabbits: A Retrospective Study

et al. 2007

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“…This result is similar to that found in previous studies. 4,5,[8][9][10][11]13,14,22 The major breed in this study was the mixed breed, which suggests this is the most common breed of pet rabbit in Japan and the USA. The number of other breeds was too small to identify any breed predisposition.…”

Section: Discussionmentioning

confidence: 99%

“…2,3,7,[8][9][10][11][12][13]22 One pathologist showed uterine adenocarcinoma preceded by CEH in all cases by monthly sequential endometrial biopsy via laparotomy. 7,22 In contrast, another study did not support CEH as a preneoplastic lesion.…”

Section: Introductionmentioning

confidence: 99%

The Immunohistochemical Evaluation of Estrogen Receptor-α and Progesterone Receptors of Normal, Hyperplastic, and Neoplastic Endometrium in 88 Pet Rabbits

et al. 2008

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Abstract. The expression of estrogen receptor-a (ER) and progesterone receptor (PR) in normal, hyperplastic, and neoplastic endometrium in rabbits was evaluated by immunohistochemistry. The tissues evaluated were 27 normal uteri, 19 cases with endometrial hyperplasia, and 42 adenocarcinomas. Sixteen of 27 cases of normal uteri (59.3%) and 13 out of 19 hyperplasias (68.4%) stained positive with both ER-a and PR. Adenocarcinomas were further subdivided into 26 papillary and 16 tubular/solid adenocarcinomas. Papillary adenocarcinoma infiltrated the myometrium late in the disease and caused attenuation of the myometrium. In contrast, tubular/solid adenocarcinoma invaded into the deep myometrium early in the disease without thinning of the myometrium. Twenty-one cases out of 26 (80.8%) cases of papillary adenocarcinoma were both ER-a and PR negative, whereas 15 out of 16 (93.8%) of the tubular/solid adenocarcinomas were positive for ER-a, PR, or both. The total immunoreactive scores of ER-a, PR, and mode of myometrial invasion were significantly different between histopathologic types. This suggests that there may be 2 different developmental pathways for uterine adenocarcinomas in the rabbit.

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“…Lymphosarcoma has been reported infrequently in the rabbit (Polson, 1927;Greene & Strauss, 1949;Van Kampen, 1968;Weisbroth, Flatt & Kraus, 1974). In the few cases of leukaemia described the diagnosis was made post mortem, without suitable clinical pathological evaluation (Meier, Fox & Crary, 1972).…”

Section: Discussionmentioning

confidence: 99%