Multiple Pseudotumors in IgG4-Associated Multifocal Systemic Fibrosis

Vliet, Hans J. van der; Perenboom, R. M.

doi:10.7326/0003-4819-141-11-200412070-00033

Cited by 117 publications

(55 citation statements)

References 6 publications

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“…A new concept has been proposed for these conditions with special reference to the contribution of IgG4, such as IgG4-related autoimmune disease or IgG4-associated multifocal systemic fibrosis (3,4). A recent report indicated the additional complication of a pituitary lesion in patients with autoimmune pancreatitis (5). In this report, we presented the case that corresponded to the IgG4-associated multifocal systemic fibrosis complicating sclerosing sialadenitis, hypophysitis, and retroperitoneal fibrosis, but lacking pancreatic involvement.…”

Section: A High Serum Igg4 Concentration and Abundant Igg4-bearing Plmentioning

confidence: 93%

“…A new disease concept has been proposed for these conditions with special reference to the contribution of IgG4, such as IgG4-related autoimmune disease or IgG4-associated multifocal systemic fibrosis (3,5 (6). Furthermore, these conditions of sclerosing sialadenitis were reported to be closely associated with high serum IgG4 concentration and IgG4 bearing plasma cell infiltration (7,8) …”

Section: T a B L E 1 L A B O R A T O R Y Da T A O N Ad Mi S S I O Nmentioning

confidence: 99%

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IgG4-associated Multifocal Systemic Fibrosis Complicating Sclerosing Sialadenitis, Hypophysitis, and Retroperitoneal Fibrosis, but Lacking Pancreatic Involvement

et al. 2006

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Section: A High Serum Igg4 Concentration and Abundant Igg4-bearing Plmentioning

confidence: 93%

Section: T a B L E 1 L A B O R A T O R Y Da T A O N Ad Mi S S I O Nmentioning

confidence: 99%

IgG4-associated Multifocal Systemic Fibrosis Complicating Sclerosing Sialadenitis, Hypophysitis, and Retroperitoneal Fibrosis, but Lacking Pancreatic Involvement

et al. 2006

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“…Leporati et al (7), the first to report IgG4-related hypophysitis in Caucasian patients, reviewed the published literature and proposed diagnostic criteria on the basis of findings of 11 cases that were analyzed. Although the first IgG4-related hypophysitis case was described in 2004 (3), only six histologically proven cases have been reported (3,4,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21).…”

Section: Introductionmentioning

confidence: 99%

The prevalence of IgG4-related hypophysitis in 170 consecutive patients with hypopituitarism and/or central diabetes insipidus and review of the literature

Bando

Iguchi

Fukuoka

et al. 2014

European Journal of Endocrinology

119

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Objective: The prevalence and clinical characteristics of IgG4-related hypophysitis remain unclear due to the limited number of case reports. Therefore, in this study, we screened consecutive outpatients with hypopituitarism and/or diabetes insipidus (DI) to estimate its prevalence. Methods: A total of 170 consecutive outpatients with hypopituitarism and/or central DI were screened at Kobe University Hospital for detecting IgG4-related hypophysitis by pituitary magnetic resonance imaging, measuring serum IgG4 concentrations, assessing the involvement of other organs, and carrying out an immunohistochemical analysis to detect IgG4-positive cell infiltration. Results: Among the screened cases, 116 cases were excluded due to diagnosis of other causes such as tumors and congenital abnormalities. Additionally, 22 cases with isolated ACTH deficiency were analyzed and were found not to meet the criteria of IgG4-related hypophysitis. The remaining 32 cases were screened and seven were diagnosed with IgG4-related hypophysitis, of which three cases were diagnosed by analyzing pituitary specimens. IgG4-related hypophysitis was detected in 30% (seven of 23 patients) of hypophysitis cases and 4% of all hypopituitarism/DI cases. The mean age at the onset of IgG4-related hypophysitis was 61.8G8.8 years, and the serum IgG4 concentration was 191.1G78.3 mg/dl (normal values 5-105 mg/dl and values in IgG4-related disease (RD) R135 mg/dl). Pituitary gland and/or stalk swelling was observed in six patients, and an empty sella was observed in one patient. Multiple co-existing organ involvement was observed in four of the seven patients prior to the onset of IgG4-related hypophysitis. Conclusion: These data suggest that the prevalence of IgG4-related hypophysitis has been underestimated. We should also consider the possibility of the development of hypopituitarism/DI caused by IgG4-related hypophysitis during the clinical course of other IgG4-RDs.

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“…There have been 8 published cases of pituitary lesions associated with this disease [4][5][6][7][8][9][10][11]. Central diabetes insipidus and/or disturbed anterior hormone production related disease involving the pituitary gland.…”

mentioning

confidence: 99%

Putative IgG4-related pituitary disease with hypopituitarism and/or diabetes insipidus accompanied with elevated serum levels of IgG4

et al. 2010

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Multiple Pseudotumors in IgG4-Associated Multifocal Systemic Fibrosis

Cited by 117 publications

References 6 publications

IgG4-associated Multifocal Systemic Fibrosis Complicating Sclerosing Sialadenitis, Hypophysitis, and Retroperitoneal Fibrosis, but Lacking Pancreatic Involvement

IgG4-associated Multifocal Systemic Fibrosis Complicating Sclerosing Sialadenitis, Hypophysitis, and Retroperitoneal Fibrosis, but Lacking Pancreatic Involvement

The prevalence of IgG4-related hypophysitis in 170 consecutive patients with hypopituitarism and/or central diabetes insipidus and review of the literature

Putative IgG4-related pituitary disease with hypopituitarism and/or diabetes insipidus accompanied with elevated serum levels of IgG4

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