Multiple roles of serotonin in pain control mechanisms —Implications of 5-HT7 and other 5-HT receptor types

Viguier, F.; Michot, B.; Hamon, Michel; Bourgoin, S.

doi:10.1016/j.ejphar.2013.01.074

Cited by 147 publications

(122 citation statements)

References 103 publications

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“…These findings suggest that spinal 5-HT7 receptors and α2A, α2B, and α2C-adrenoceptors are involved in the effects of areca nut in the spinal cord. The 5-HT7 receptor was recently identified [13] and localized in the spinal cord by immunohistochemistry [24]. Moreover, intrathecal 5-HT7 receptor agonists have been shown to inhibit mechanical hypersensitivity significantly in nerve injury-induced NP [25].…”

Section: Discussionmentioning

confidence: 99%

“…These 2 monoamines act, respectively, on 5-HT receptors and α-adrenoceptors in the spinal cord. In particular, the roles of 5-HT7 and α2-adrenergic receptors on nociceptive modulation in the spinal cord have been highlighted [12,13]. Interestingly, areca nut exhibits antidepressant activity, which is mediated via the elevation of 5-HT and noradrenaline in the brain [14].…”

Section: Introductionmentioning

confidence: 99%

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Antiallodynic Effects of Intrathecal Areca Nut for Spinal Nerve-Ligated and Chemotherapy-Induced Neuropathic Pain in Rats

et al. 2018

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This study examined the effects of intrathecal areca nut on spinal nerve-ligated and chemotherapy-induced neuropathic pain (NP), and investigated the relevance of spinal 5-hydroxytryptamine (5-HT) and α2-adrenergic receptors to those effects. For drug administration, intrathecal catheters were inserted into the subarachnoid space of male Sprague-Dawley rats. NP was induced either by spinal nerve ligation (left spinal nerves L5 and L6) or by chemotherapeutic injection (intraperitoneal cisplatin, 2 mg/kg/day, once daily for 4 days). Paw withdrawal thresholds (PWT) were mechanically assessed using von Frey filaments. The involvement of 5-HT and α2-adrenergic receptors in antiallodynia was determined using antagonists with the following receptor specificities: nonselective 5-HT (dihydroergocristine), 5-HT7 (SB269970), nonselective α2-adrenoceptor (yohimbine), α-2A (BRL 44408), α-2B (ARC 239), and α-2C (JP 1302). Intrathecal areca nut significantly increased the PWT in both spinal nerve-ligated and chemotherapy-induced NP (^‡ p < 0.001). Intrathecal dihydroergocristine, SB269970, yohimbine, BRL 44408, ARC 239, and JP 1302 significantly reversed the antiallodynic effects of areca nut in both NP states (^‡ p < 0.001). Collectively, intrathecal areca nut suppressed mechanical allodynia induced by spinal nerve ligation and cisplatin injection. Furthermore, spinal 5-HT7 receptor and α2A, α2B, and α2C-adrenoceptors contributed to the antiallodynic effects of areca nut.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antiallodynic Effects of Intrathecal Areca Nut for Spinal Nerve-Ligated and Chemotherapy-Induced Neuropathic Pain in Rats

et al. 2018

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“…5-HT receptor subtypes mediating its effect and the pathophysiological status of the animal also play role in these dual actions of 5-HT. 31 Serotonin receptor antagonists induced hyperalgesia without preventing morphine antinociception; 1 moreover, 5-HT3 receptors has been shown to mediate descending pain facilitation and pronociceptive effects of opioids, 10,16 pointing to the role of 5-HT receptor subtypes in opiod action and hyperalgesia. Recent research is focusing on 5-HT7 receptors, and this receptor system has been implicated in circadian rhythm, nociception, thermoregulation, memory, anxiety, depression and schizophrenia.…”

Section: -Ht7 Receptors In Nociceptionmentioning

confidence: 98%

5-HT7 receptor activation: A novel target for treatment of opioid-induced hyperalgesia – A hypothesis and mini review

Topuz

Gündüz

Ulugöl

2015

Neurology, Psychiatry and Brain Research

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“…Collectively, the antinociceptive effects of PH mainly occur via the central nervous system. Among monoamine neurotransmitters, 5-HT shows essentially pro-nociceptive effects at the periphery and anti-nociceptive effects when it is injected directly at the spinal cord level (Viguier et al, 2013). 5-HT is widely accepted as a key neurotransmitter in the pathophysiology of migraines, and low levels of 5-HT are found in patients who suffer from chronic daily headaches (le Grand et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Anti-nociceptive effects of Paecilomyces hepiali via multiple pathways in mouse models

Wang

Jia

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Paecilomyces hepiali (PH), a well-known medicinal fungus, has various pharmacological efficacies. In our study, the antinociceptive effects of PH and underlying mechanisms were evaluated using various mouse models. An acetic acid-induced writhing test, hot plate test, and formalin test were employed to evaluate the antinociceptive activities of PH. The levels of neuronal nitric oxide synthase (nNOS) in the hypothalamus and monoamine neurotransmitters in the serum and hypothalamus of experimental mice were examined. Additionally, hot plate tests using mice pretreated with various antagonists were used to determine the mechanisms of PHmediated antinociception. The PH-enhanced latency period of mice in the hot plate test was significantly blocked by pretreatment with atropine and glibenclamide. PH shortened the phase I and phase II reaction times of formalin-treated mice. Strongly reduced writhing and stretching induced by acetic acid were observed in PH-treated mice, indicating that PH mainly exerts antinociceptive activity on neurogenic pain. After thermal pain stimulation for 30 s, compared to control mice, 7-day PH-treated mice had lower nNOS and dopamine levels, and increased levels of serotonin in both the serum and hypothalamus. Collectively, our data showed that PH mediated antinociceptive activities via multiple pathways, including monoamines, nNOS/ATPsensitive K + channels, and M-type acetylcholine receptors.

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Multiple roles of serotonin in pain control mechanisms —Implications of 5-HT7 and other 5-HT receptor types

Cited by 147 publications

References 103 publications

Antiallodynic Effects of Intrathecal Areca Nut for Spinal Nerve-Ligated and Chemotherapy-Induced Neuropathic Pain in Rats

Antiallodynic Effects of Intrathecal Areca Nut for Spinal Nerve-Ligated and Chemotherapy-Induced Neuropathic Pain in Rats

5-HT7 receptor activation: A novel target for treatment of opioid-induced hyperalgesia – A hypothesis and mini review

Anti-nociceptive effects of Paecilomyces hepiali via multiple pathways in mouse models

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