Multiple SARS-CoV-2 introductions shaped the early outbreak in Central Eastern Europe: comparing Hungarian data to a worldwide sequence data-matrix

Kemenesi, Gábor; Zeghbib, Safia; Somogyi, B; Tóth, Gábor Endre; Bányai, Krisztiàn; Solymosi, Norbert; Szabó, Péter M.; Szabó, István; Bálint, Ádám; Herczeg, Róbert; Gyenesei, Attila; Nagy, Ágnes; Pereszlényi, Csaba István; Babinszky, Gergely Csaba; Dudás, Gábor; Terhes, Gabriella; Zöldi, Viktor; Lovas, Róbert; Tenczer, Szabolcs; Kornya, László; Jakab, Ferenc

doi:10.1101/2020.05.06.080119

Cited by 6 publications

(4 citation statements)

References 17 publications

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“…Thus far, multiple studies have been conducted to demonstrate the spread of COVID-19 using nationwide and global comparative genome surveillance; as of 2 June 2020, there were already 33,483 complete genomes publicly available on the Global Initiative on Sharing All Influenza Data (GISAID) platform ( 4 ). Some detailed reports have been conducted to highlight region-specific clusters and intra- and international spread observed in the United States ( https://covidgenomics.org/ ), the United Kingdom ( https://www.cogconsortium.uk/ ), Hungary ( 5 ), Australia ( 6 ), Denmark ( 7 ), Iceland ( 8 ), and California ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

A Genome Epidemiological Study of SARS-CoV-2 Introduction into Japan

Sekizuka

Itokawa

Hashino

et al. 2020

mSphere

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After the first case of coronavirus disease 2019 (COVID-19) in Japan on 15 January 2020, multiple nationwide COVID-19 clusters were identified by the end of February. The Japanese government focused on mitigating the emerging COVID-19 clusters by conducting active nationwide epidemiological surveillance. However, an increasing number of cases continued to appear until early April 2020, many with unclear infection routes and no recent history of travel outside Japan. We aimed to evaluate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome sequences from the COVID-19 cases that appeared until early April 2020 and to characterize their genealogical networks in order to demonstrate possible routes of spread in Japan. Nasopharyngeal specimens were collected from patients, and reverse transcription-quantitative PCR tests for SARS-CoV-2 were performed. Positive RNA samples were subjected to whole-genome sequencing, and a haplotype network analysis was performed. Some of the primary clusters identified during January and February 2020 in Japan descended directly from the Wuhan-Hu-1-related isolates from China and other distinct clusters. Clusters were almost contained until mid-March; the haplotype network analysis demonstrated that the COVID-19 cases from late March through early April may have created an additional large cluster related to the outbreak in Europe, leading to additional spread within Japan. In conclusion, genome surveillance has suggested that there were at least two distinct SARS-CoV-2 introductions into Japan from China and other countries. IMPORTANCE This study aimed to evaluate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome sequences from COVID-19 cases and to characterize their genealogical networks to demonstrate possible routes of spread in Japan. We found that there were at least two distinct SARS-CoV-2 introductions into Japan, initially from China and subsequently from other countries, including Europe. Our findings can help understand how SARS-CoV-2 entered Japan and contribute to increased knowledge of SARS-CoV-2 in Asia and its association with implemented stay-at-home/shelter-in-place/self-restraint/lockdown measures. This study suggested that it is necessary to formulate a more efficient containment strategy using real-time genome surveillance to support epidemiological field investigations in order to highlight potential infection linkages and mitigate the next wave of COVID-19 in Japan.

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Section: Introductionmentioning

confidence: 99%

A Genome Epidemiological Study of SARS-CoV-2 Introduction into Japan

Sekizuka

Itokawa

Hashino

et al. 2020

mSphere

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“…A járvány későbbi szakaszában, eltérő helyeken élő, különböző súlyosságú tüneteket mutató fertőzöttek klinikai mintáiból izolált 104 törzs teljesgenom-szekvenálásának eredményeként bebizonyosodott, hogy a keringő vírustörzsek 99.9%-os homológiát mutatnak, anélkül, hogy jelentős mutációkat hordoznának [5,6]. Pécsi kutatók által végzett genomikai analízis szerint a vírus valószínűleg több nyugat-európai forrásországból, időben párhuzamosan zajló belépések során kerülhetett hazánkba [7].…”

Section: A Sars-cov-2 Genetikájaunclassified

Az új típusú koronavírus okozta megbetegedés (COVID–19): összefoglaló hematológusoknak I. – virológia, molekuláris patogenezis és klinikum

Szabó

Bobek²,

Réti³

et al. 2020

Hematológia–Transzfuziológia

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Absztrakt: A COVID–19 a SARS-CoV-2 vírus által okozott, járványosan terjedő, légúti kiindulású betegség. A kórokozó magas patogenitású, zoonotikus eredetű humán coronavírus, mely hatékonyan terjed emberről emberre cseppfertőzéssel és közeli kontaktussal. A medián lappangási idő 5 nap, a maximum 14 nap. A COVID–19 kardinális tünetei a láz, dyspnoe és száraz köhögés. Az esetek 80%-a enyhe lefolyású, 5%-ban azonban intenzív terápiás ellátás és gépi lélegeztetés válik szükségessé. A COVID–19 akár súlyos, az egész szervezetre kiterjedő citokinvihart is kiválthat, mely gyors beavatkozás nélkül végzetes kimenetelű lehet. Jelen összefoglaló – melyet a diagnosztikai és terápiás szempontokat tárgyaló társközlemény követ – a betegséggel kapcsolatban 2020. május 25-ig elérhető legfőbb nemzetközi és hazai irodalmi eredményeket ismerteti; elsősorban, de nem kizárólag hematológus kollégák számára.

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“…Coronavirus disease 2019 (COVID-19) was first identified as pneumonia of unknown cause in China in December 2019 [ 1 ], and has since spread rapidly worldwide [ 2 ]. South Korea reported its first COVID-19 infection at the beginning of the global spread, due to the country’s close geographical proximity to China [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Infection Prevention Performance among In-Flight Cabin Crew in South Korea

Ryu

Kim²,

Choi-Kwon

2021

IJERPH

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COVID-19 was declared a worldwide pandemic in 2020; thus, preventing in-flight infection transmission is important for stopping global spread via air travel. Infection prevention (IP) performance among aircraft cabin crew is crucial for preventing in-flight transmission. We aimed to identify the level of IP performance and factors affecting IP performance among aircraft cabin crew during the COVID-19 pandemic in South Korea. An online survey was conducted with 177 cabin crew members between August and September 2020. The survey assessed IP performance, and IP awareness, using a five-point Likert scale, and also evaluated simulation-based personal protective equipment (PPE) training experience, and organizational culture. The average IP performance score was 4.56 ± 0.44. Although the performance level for mask-wearing was high (4.73 ± 0.35), hand hygiene (HH) performance (4.47 ± 0.56) was low. Multivariate analysis showed that IP performance was significantly associated with IP awareness (p < 0.05) and simulation-based PPE training experience (p < 0.05). Since HH performance was relatively low, cabin crew and airlines should make efforts to improve HH performance. Furthermore, a high level of IP awareness and PPE training experience can improve IP performance among cabin crew members. Therefore, simulation-based PPE training and strategies to improve IP awareness are essential for preventing in-flight infection transmission.

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Multiple SARS-CoV-2 introductions shaped the early outbreak in Central Eastern Europe: comparing Hungarian data to a worldwide sequence data-matrix

Cited by 6 publications

References 17 publications

A Genome Epidemiological Study of SARS-CoV-2 Introduction into Japan

A Genome Epidemiological Study of SARS-CoV-2 Introduction into Japan

Az új típusú koronavírus okozta megbetegedés (COVID–19): összefoglaló hematológusoknak I. – virológia, molekuláris patogenezis és klinikum

Infection Prevention Performance among In-Flight Cabin Crew in South Korea

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