Multiple Sclerosis and Autoimmune Diseases

Baker, H.W. Gordon; Balla, JÃ3zsef; Burger, Huibert; Ebeling, Peter R.; Mackay, Ian R.

doi:10.1111/j.1445-5994.1972.tb03071.x

Cited by 48 publications

(29 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Considering MS, in 1972 an initial uncontrolled retrospective study of 326 Australian patients revealed coexistence in nine with some other autoimmune disease, including thyroiditis in four [45]. A later case-controlled study of 117 patients and their relatives with a questionnaire design revealed moderate increases in prevalence of other autoimmune diseases including thyroiditis and RA in patients and/or relatives [46].…”

Section: Autoimmune Diseases For Which Coexistence Is Debatable: Ms Amentioning

confidence: 95%

Clustering and commonalities among autoimmune diseases

Mackay

2009

Journal of Autoimmunity

View full text Add to dashboard Cite

Section: Autoimmune Diseases For Which Coexistence Is Debatable: Ms Amentioning

confidence: 95%

Clustering and commonalities among autoimmune diseases

Mackay

2009

Journal of Autoimmunity

View full text Add to dashboard Cite

“…Several studies have evaluated the occurrence of autoimmune thyroid disease (AIT) in the multiple sclerosis (MS) population, reporting prevalences ranging from 0.92 to 13.9% [1,2]. Some of these studies suggested that AIT is more common in individuals with MS as compared to the findings expected for the general population [3,4,5]; however, most of these studies did not use contemporaneous control groups.…”

Section: Introductionmentioning

confidence: 99%

The Incidence and Prevalence of Thyroid Disease Do Not Differ in the Multiple Sclerosis and General Populations: A Validation Study Using Administrative Data

Marrie¹,

Leung

et al. 2012

Neuroepidemiology

View full text Add to dashboard Cite

Background: Prior studies of a possible increased risk of autoimmune thyroid disease (AIT) in multiple sclerosis (MS) are inconsistent. We aimed to validate and apply administrative case definitions for the surveillance of AIT in MS. Methods: We used administrative health data to identify 4,192 persons with MS and an age-, sex- and geographically matched general population cohort (n = 20,940). We developed case definitions for AIT using International Classification of Disease-9/10 codes and prescription claims, compared them to medical records and applied them to estimate the incidence and prevalence of AIT. Results: When compared to medical records, the administrative case definition using ≥1 hospital or ≥2 physician or ≥2 prescription claims had a sensitivity of 73.5% and specificity of 98.4%. In 2005, the age-adjusted prevalence of AIT was 9.51% [95% confidence interval (CI) 8.46–10.6] in the MS population and 8.56% (95% CI 8.11–9.02) in the general population. The age-adjusted incidence of AIT per 100,000 persons per year was 422.8 (95% CI 204.4–641.3) in the MS population and 407.7 (95% CI 308.5–506.9) in the general population. From 1996 to 2005, the prevalence of AIT rose in both populations. Conclusion: Administrative data can be used for surveillance of AIT in MS. The incidence and prevalence of thyroid disease are similar in the MS and general populations.

show abstract

“…Moreover, four of the nine patients were women and ATAbs seropositive. To our knowledge, two cases of classic MS associated with asymptomatic chronic autoimmune thyroiditis have been reported from Spain [17] and New Zealand [1]. Thus serum ATAbs are commonly detected, but not exclusively in OSMS.…”

Section: Discussionmentioning

confidence: 92%

Optic-spinal form of multiple sclerosis and anti-thyroid autoantibodies

Sakuma

Fujihara

Sato³

et al. 1999

Journal of Neurology

View full text Add to dashboard Cite

The optic-spinal form of multiple sclerosis (OSMS), characterized by recurrent involvement of optic nerve and spinal cord with rare brain magnetic resonance imaging lesions, is relatively common among Asians. While individual cases of OSMS with anti-thyroid autoantibodies (ATABs) have been reported, the frequency of ATAbs in OSMS and classical multiple sclerosis has not been studied. We studied serum ATAbs and anti-nuclear antibodies (ANA) in 46 Japanese patients with multiple sclerosis: 14 with OSMS, and 32 with non-OSMS. Six patients were positive for ATAbs: five women with OSMS and one man with non-OSMS. The frequency of ATAbs in OSMS (5/14) was significantly higher than that in non-OSMS (1/32; P = 0.007), but the frequency of ANA did not differ between OSMS (3/14) and non-OSMS (6/32; P = 0.99). There may be a pathogenetic link between anti-thyroid autoimmunity and a subgroup of OSMS in Japanese.

show abstract

Multiple Sclerosis and Autoimmune Diseases

Cited by 48 publications

References 24 publications

Clustering and commonalities among autoimmune diseases

Clustering and commonalities among autoimmune diseases

The Incidence and Prevalence of Thyroid Disease Do Not Differ in the Multiple Sclerosis and General Populations: A Validation Study Using Administrative Data

Optic-spinal form of multiple sclerosis and anti-thyroid autoantibodies

Contact Info

Product

Resources

About