Multiple sclerosis and bipolar disorders: The burden of comorbidity and its consequences on quality of life

Carta, Mauro Giovanni; Moro, Maria Francesca; Lorefice, Lorena; Picardi, Angelo; Trincas, Giuseppina; Fenu, Giuseppe; Cocco, Eleonora; Floris, Francesco; Bessonov, Daniel; Akiskal, Hagop S.; Marrosu, Maria Giovanna

doi:10.1016/j.jad.2014.05.024

Cited by 41 publications

(39 citation statements)

References 43 publications

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“…We measured the ' attributable burden ' as the difference between the endangerment of quality of life of those suffering from any eating disorders and the level of subjective quality of life in the community sample without eating disorders indirectly standardized by age and sex by the eating disorder sample. The attributable burden due to eating disorders was compared with the attributable burden calculated for other diseases in previous studies coming from the same database or from case-control studies adopting the same database from which were drawn the controls (Carta et al, 2014a).…”

Section: Discussionmentioning

confidence: 99%

Eating disorders as a public health issue: Prevalence and attributable impairment of quality of life in an Italian community sample

Carta

Preti

Moro

et al. 2014

International Review of Psychiatry

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The prevalence of eating disorders (ED) in the community is still under debate, as well as the measure of their impact on the well-being of individuals. It was decided to evaluate the prevalence of eating disorders in an Italian community sample as well as to measure the burden of the quality of life of people and to compare it to those attributable to other chronic illnesses. A community survey of 4,999 people using a questionnaire on health services utilization, the Advanced Neuropsychiatric Tools and Assessment Schedule (ANTAS), a semi-structured clinical interview derived from the non-patient version of the DSM-IV (SCID/NP) and Short Form Health Survey (SF-12) was conducted. A total of 3,398 individuals were interviewed (68% of those recruited). Lifetime prevalence for overall ED was 1.7%; for anorexia 0.7%; for bulimia 0.6% and for binge eating disorder 0.5%. ED was more frequent in women than in men. No cases of anorexia in men were identified. ED showed an attributable burden in impairing quality of life with no statistically significant differences with those due to major depressive disorder, bipolar spectrum disorders and Wilson's disease. Of the pathological conditions considered, only multiple sclerosis showed a worsening attributable burden. ED thus has a non-negligible frequency in Italy, with severe impact on quality of life comparable to that produced by severe chronic psychiatric and general medical conditions. These elements emphasize that ED is a serious public health issue.

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Section: Discussionmentioning

confidence: 99%

Eating disorders as a public health issue: Prevalence and attributable impairment of quality of life in an Italian community sample

Carta

Preti

Moro

et al. 2014

International Review of Psychiatry

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“…Specifically, worse HRQoL has been observed for patients with MS with clinical diagnoses of depression and selfreported depression symptoms in both crosssectional and longitudinal studies. 1,26,[31][32][33] As in the present study, when multiple determinants of HRQoL in MS have been examined concurrently, depression has frequently emerged as one of the most, if not the most, important predictors.…”

Section: Methods Study Population From July 2010 Throughmentioning

confidence: 99%

Health-related quality of life in multiple sclerosis

et al. 2016

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Objective: To evaluate the direct and indirect influences of physical comorbidity, symptoms of depression and anxiety, fatigue, and disability on health-related quality of life (HRQoL) in persons with multiple sclerosis (MS).Methods: A large (n 5 949) sample of adults with MS was recruited from 4 Canadian MS clinics.HRQoL was assessed using the patient-reported Health Utilities Index Mark 3. Expanded Disability Status Scale scores, physical comorbidity, depression, anxiety, and fatigue were evaluated as predictors of HRQoL in a cross-sectional path analysis.Results: All predictors were significantly associated with HRQoL and together accounted for a large proportion of variance (63%). Overall, disability status most strongly affected HRQoL (b 5 20.52) but it was closely followed by depressive symptoms (b 5 20.50). The direct associations of physical comorbidity and anxiety with HRQoL were small (b 5 20.08 and 20.10, respectively), but these associations were stronger when indirect effects through other variables (depression, fatigue) were also considered (physical comorbidity: b 5 20.20; anxiety: b 5 20.34).Conclusions: Increased disability, depression and anxiety symptoms, fatigue, and physical comorbidity are associated with decreased HRQoL in MS. Disability most strongly diminishes HRQoL and, thus, interventions that reduce disability are expected to yield the most substantial improvement in HRQoL. Yet, interventions targeting other factors amenable to change, particularly depression but also anxiety, fatigue, and physical comorbidities, may all result in meaningful improvements in HRQoL, as well. Our findings point to the importance of further research confirming the efficacy of such interventions.

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“…11,12 In bried, controls were randomly drawn from municipal records of the adult population in seven different areas of Italy, including several localities with wide variations in socioeconomic conditions. The regions of Sicily, Sardinia, and Puglia in the South, Tuscany and Abruzzo in central Italy, and Friuli-Venezia Giulia in the North were included.…”

Section: Samplementioning

confidence: 99%

An evolutionary approach to mania studying Sardinian immigrants to Argentina

Carta

Perra

Atzeni

et al. 2017

Rev. Bras. Psiquiatr.

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Objective: To ascertain lifetime prevalence of positivity to a screening questionnaire for bipolar disorders (BD) in Sardinian immigrants to Argentina and residents of Sardinia and assess whether such positivity affects quality of life (QoL) in either group. Our hypothesis is that screen positivity for BD may be more frequent in immigrants. Methods: Observational study. Subjects were randomly selected from the membership lists of associations of Sardinian immigrants in Argentina. A study carried out in Sardinia using the same methodology was used for comparison. The Mood Disorder Questionnaire was used to screen for mania/hypomania and the Short-Form Health Survey-12 to measure QoL. Results: A higher prevalence of manic/hypomanic episodes was found in Sardinian immigrants to Argentina (p o 0.0001; odds ratio = 3.0, 95% confidence interval 1.87-4.77). Positivity at screening was associated with a lower QoL both in Sardinian immigrants to Argentina and in residents of Sardinia. Conclusions: To the best of our knowledge, this is the first study to show a higher lifetime prevalence of manic/hypomanic episodes in a general-population sample of individuals who migrated to a foreign country. Our results are in agreement with the hypothesis that hyperactive/novelty-seeking features may represent an adaptive substrate in certain conditions of social change.

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Multiple sclerosis and bipolar disorders: The burden of comorbidity and its consequences on quality of life

Cited by 41 publications

References 43 publications

Eating disorders as a public health issue: Prevalence and attributable impairment of quality of life in an Italian community sample

Eating disorders as a public health issue: Prevalence and attributable impairment of quality of life in an Italian community sample

Health-related quality of life in multiple sclerosis

An evolutionary approach to mania studying Sardinian immigrants to Argentina

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