Multiple Sclerosis Associated With Anaemic Syndrome: A Retrospective Analysis and Literature Review

Deleva, Nadezhda

doi:10.5272/jimab.2012181.203

Cited by 3 publications

(5 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A sensory fiber abnormality has been reported in RLS patients . Clinical studies showed a high prevalence of RLS in patients with celiac disease and multiple sclerosis, who have iron‐deficiency anemia and peripheral neuropathy . Peripheral nerve conduction velocity has been found to be positively correlated with hemoglobin and hematocrit levels .…”

Section: Discussionmentioning

confidence: 96%

Motor hyperactivity of the iron‐deficient rat — an animal model of restless legs syndrome

et al. 2017

View full text Add to dashboard Cite

Background Abnormal striatal dopamine transmission has been hypothesized to cause the restless legs syndrome. Dopaminergic drugs are commonly used to treat restless legs syndrome. However, they cause adverse effects with long term use. An animal model would allow the systematic testing of potential therapeutic drugs. Objectives A high prevalence of restless legs syndrome was reported in iron deficient anemic patients. We hypothesized that the iron deficient animal exhibits signs similar to those in restless legs syndrome patients. Methods After baseline polysomnographic recordings iron deficient rats received pramipexole injection. Then, iron deficient rats were fed a standard rodent diet and polysomnographic recording were performed for 2 days each week for 4 weeks. Results Iron deficient rats have low hematocrit levels and show signs of restless legs syndrome: sleep fragmentation and periodic leg movements in wake and in slow wave sleep. Iron deficient rats had a positive response to pramipexole treatment. After the iron deficient rats were fed the standard rodent diet, hematocrit returned to normal levels, sleep quality improved, with increased average duration of wake and slow wave sleep episodes. Periodic leg movements decreased during both waking and sleep. Hematocrit levels positively correlated with the average duration of episodes in wake and in slow wave sleep, and negatively correlated with periodic leg movements in wake and in sleep. Western blot analysis showed that striatal dopamine transporter levels were higher in iron deficient rats. Conclusions The iron deficient rat is a useful animal model of iron deficient anemic restless legs syndrome.

show abstract

Section: Discussionmentioning

confidence: 96%

Motor hyperactivity of the iron‐deficient rat — an animal model of restless legs syndrome

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The possible cause of low hemoglobin levels in our subjects can be explained by referring to study of Deleva [35] in which the researchers examined the relationship between MS and different types of anemia (anaemic syndrome). In their study, 18 MS patients (13 of them were diagnosed with the relapsing-remitting type of MS) were examined in terms of some types of anemia.…”

Section: Discussionmentioning

confidence: 99%

“…They described the subjects as eight patients with pernicious anemia, three patients with iron deficiency anemia, 6 patients with vitamin B12 deficiency, and one patient who was diagnosed with heterozygous thalassemia. Deleva [35] concluded that there is a significant relationship between MS and various types of anemia. Therefore, the possible cause of low hemoglobin level in most patients of the present study could be due to anaemic syndrome and multifactorial anemia.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis

2019

View full text Add to dashboard Cite

Plasma homocysteine level and megaloblastic anemia status are two factors that can affect the quality of life of patients with multiple sclerosis (MS). We conducted this study to determine the effect of vitamin B12 and folic acid supplementation on serum homocysteine, megaloblastic anemia status and quality of life of patients with MS. A total of 50 patients with relapsing remitting multiple sclerosis (RRMS) included in this study which divided into 2 groups. The vitamin group received 5 mg folic acid tablet daily and 3 doses of vitamin B12 (1,000 mcg) injection and the other group received placebo and normal saline injection (same doses). The quality of life was measured by using Multiple Sclerosis Quality of Life-54 questionnaire (MSQOL-54). Fully automated fluorescence polarization immunoassay was used to measure serum homocysteine, vitamin B12 and folate. Complete blood count blood test was conducted to determine the anemia status. The mean homocysteine level reduced by 2.49 ± 0.39 µmol/L (p = 0.001), hemoglobin increased from 11.24 ± 1.54 to 13.12 ± 1.05 g/dL (p = 0.001), and mean corpuscular volume decreased from 95.50 ± 6.65 to 89.64 ± 4.24 in the vitamin group (p = 0.001). There was a significant improvement in the mental field of life quality in the placebo group (37.46 ± 19.01 to 50.98 ± 21.64; p = 0.001), whereas both physical and mental fields of quality of life were improved significantly in the vitamin group (40.38 ± 15.07 to 59.21 ± 12.32 and 29.58 ± 15.99 to 51.68 ± 18.22, respectively; p = 0.001). Serum homocysteine level decrease and anemia status improvement with vitamin B12 and folic acid supplementation reveal the potential role of these two vitamins in improving the life quality of MS patients.Trial RegistrationIranian Registry of Clinical Trials Identifier: IRCT2015100313678N7

show abstract

“…Another study (Kumar et al, 2010) indicates that iron deficiency is associated with impairment of cell mediated immunity [29]. Accordingly, the combination between [25], [26] and [29] supports the lower level of iron and the higher level of HbA 1c in multiple sclerosis patients. Consequently, the present study indicates the opposite correlation between (hemoglobin / Fe) and glycated hemoglobin A 1c levels, Table (1).…”

Section: Discussionmentioning

confidence: 86%

“…An association between multiple sclerosis and anemic syndromes (results from a decrease in iron level) has been reported. In this regard, a previous study (Deleva et al, 2012) has suggested that the coincidence of anemia with multiple sclerosis has been consider to impact seriously on clinical presentation, therapeutic strategy and the patients quality of life [25]. Another study (Sinha et al, 2012) has investigated the effect of iron deficiency anemia on HbA 1c levels, they observed that HbA 1c levels are higher in iron deficiency anemia patients.…”

Section: Discussionmentioning

confidence: 99%

Positive and Negative Aspects of Copaxone ( Glatiramer acetate) Action on TC, TG HbA1c and Iron Levels in The Sera of Iraqi Women with Multiple Sclerosis in Baghdad

Journal¹

2017

Baghdad Sci.J

View full text Add to dashboard Cite

The aim of the present study is to highlight the role of total cholesterol (TC), triacylglycerol (TG), Glycated hemoglobin A1c and iron in Iraqi women with multiple sclerosis and also to examine the biochemical action of copaxone (which is the most widely used in the 21st century to treat multiple sclerosis) on these biochemical parameters. This is the first study in Iraq which deals copaxone action on TC , TG , HbA1c and iron. Ninety women in their fourth decade suffering from multiple sclerosis were enrolled in this study. They were divided into: the first (group B) composed of (30) women without any treatment related to multiple sclerosis or any treatment linked with chronic or inflammatory diseases. The second (group A1) included (30) women under treatment with copaxone for 1 year, whereas the third group (group A2) involved (30) women under treatment with copaxone for 2 years. Patients groups were compared with a healthy control group (group C) composed of (30) healthy women, TC, TG, HbA1c and iron levels were determined in the sera of patients and control groups. Results of the present study has revealed that TC was high significantly increasing in the sera of group B (250.68±9.76) mg/dl compared with group C (175.36±8.81) mg/dl, while it was high significantly decreasing in the sera of groups A1 (211.88±5.90) mg/dl and A2 (212.12±5.60) mg/dL compared with group B (250.68±9.76) mg/dl. Beside, a non-significant difference was suggested between groups A1 (211.88±5.90) mg/dl and A2 (212.12±5.60) mg/dl. The present study also reported that TG was high significantly increasing in group B (224.84±10.76) mg / dl compared with group C (131.36±7.53) mg/dL whereas a significant decrease was shown in group A1(142.48±4.63) mg/dl and group A2 (195±4.20) mg/dl compared with group B (224.84±10.76) mg / dl. Surprisingly, a highly significant increase was reported in group A2 (195±4.20) mg/dl compared with group A1(142.48±4.63) mg/dl. The present study also suggested that HbA1c level was high significantly increasing in the sera of group B (6.53±0.57) mg/dl compared with group C (4.99±0.07) mg/dl. Oppositely, it was high significantly decreasing in the sera of groups A1 (4.72±0.42) mg/dl and A2 (4.53±0.35) mg/dl compared with group B (6.53±0.57) mg/dl. Futhermore, a non-significant difference was noted between groups A1 (4.72±0.42) mg/dl and A2 (4.53±0.35) mg/dl. This study also reported that iron level was high significantly decreasing in the sera of group B (37.31±4.24) µg / dl compared with group C (98.23±9.21) µg/ dl, whereas it was significantly increasing in the sera of groups A1 (44.05±6.32) µg/dl and A2 (45.31±6.82) µg/dl compared with group B (37.31±4.24) µg/dl . A non significant difference was shown between groups A1 (44.05±6.32) µg / dl and A2 (45.31±6.82) µg / dl.

show abstract

Multiple Sclerosis Associated With Anaemic Syndrome: A Retrospective Analysis and Literature Review

Cited by 3 publications

References 12 publications

Motor hyperactivity of the iron‐deficient rat — an animal model of restless legs syndrome

Motor hyperactivity of the iron‐deficient rat — an animal model of restless legs syndrome

The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis

Positive and Negative Aspects of Copaxone ( Glatiramer acetate) Action on TC, TG HbA1c and Iron Levels in The Sera of Iraqi Women with Multiple Sclerosis in Baghdad

Contact Info

Product

Resources

About