“…The prevalence of MS in Ferrara, a City located in the South-east part of the Plain (Fig. 2), progressively increased from 26.9/100,000 in 1978 to 46.1/100,000 in 1981, 69.4/100,000 in 1993, 120.9/100,000 in 2004 and 194.9/100,000 in December 31, 2016 [12,13]. This trend was strikingly superimposable to that observed in the Province of Padua, located about 70 km North from Ferrara, where MS prevalence progressively increased from 16/100,000 in 1974 to 45.7/100,000 in 1990, 80.5/100,000 in 1999, 139.5/100,000 in 2009, 180/100,000 in 2015 and 220/100,000 in 2020, with a peak of 245/100,000 in urban area of Padua [10,[14][15][16][17].…”