Multiple sclerosis in the elderly: a retrospective cohort study

Zinganell, Anne; Göbel, Georg; Berek, Klaus; Hofer, Barbara; Asenbaum-Nan, Susanne; Barang, Matin; Böck, Klaus; Bsteh, Christian; Bsteh, Gabriel; Eger, Stephan; Eggers, Christian; Fertl, Elisabeth; Joldic, Damir; Khalil, Michael; Langenscheidt, Dieter; Komposch, Martina; Kornek, Barbara; Kraus, Jörg; Krendl, Reinhard; Rauschka, Helmut; Sellner, Johann; Auer, Michael; Hegen, Harald; Pauli, Franziska Di; Deisenhammer, Florian

doi:10.1007/s00415-023-12041-1

Cited by 3 publications

(1 citation statement)

References 68 publications

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“…In women it usually has an earlier onset than in men, and women are two to three times more at risk of developing it than men [ 3 , 4 ]. Generally, the first symptoms of MS can be detected between the ages of 20 and 40 years, and appear in childhood in less than 1% of sufferers, although the prevalence of late-onset MS (debut above the age of 50 years) ranges from 4 to 9.4 [ 5 , 6 ]. MS is more common in colder regions and among Caucasians [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of Cognitive Impairment on Quality of Life in Multiple Sclerosis Patients—A Comprehensive Review

Gómez-Melero,

Caballero-Villarraso,

Escribano

et al. 2024

JCM

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Multiple sclerosis (MS) is characterized by a variety of symptoms that have a major impact on quality of life (QoL) even in early stages. In addition to individual motor, sensory, visual disturbances, and brainstem and sphincter disorders, which are expressed through the widely used Expanded Disability Status Scale (EDSS), other manifestations of MS have a detrimental effect on overall functioning and quality of life, such as cognitive impairment, depression, anxiety, fatigue, and pain. However, when talking about QoL, categorical definitions cannot be used because although the concept is generally understood, it is highly nuanced. Suffering from MS can significantly reduce QoL. Numerous research studies have focused on trying to identify and assess which are the elements that most affect the loss of QoL in MS people. However, in addition to the fact that the measurement of QoL can be subjective, it is very difficult to consider these elements in isolation, as they are interrelated. One such limiting factor of QoL that has been investigated is cognitive impairment (CI). This has been shown to have an impact on the lives of MS people, although the different approaches that have been taken to assess CI have evident limitations.

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Section: Introductionmentioning

confidence: 99%

Impact of Cognitive Impairment on Quality of Life in Multiple Sclerosis Patients—A Comprehensive Review

Gómez-Melero,

Caballero-Villarraso,

Escribano

et al. 2024

JCM

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The overall and smoking-attributable burden of multiple sclerosis among older adults aged 65–89 years from 1990 to 2019 and predictions to 2040

Su,

Liang,

2024

Front. Med.

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BackgroundThe global prevalence of aging individuals with multiple sclerosis (MS) is increasing. This study aimed to assess the burden and trends of overall and smoking-attributable MS in older adults aged 65–89 years at the global, regional, and national levels.MethodsThe number and rates of years of life lived with disability (YLD) and years of life lost (YLL) due to MS for older adults in 204 countries and territories from 1990 to 2019 were retrieved from the Global Burden of Disease (GBD) Study 2019. Estimated annual percentage change (EAPC) in the age-standardized YLD and YLL rates were calculated to quantify the temporal trends. The Bayesian age-period-cohort model was used to predict the trends from 2020 to 2040.ResultsIn 2019, there were an estimated 80,040 (95% uncertainty interval 57,534 to 103,608) YLD and 139,132 (107,632 to 161,172) YLL caused by MS among older adults globally. The age-standardized YLD and YLL rates decreased by an average of −0.21% (95% CI –0.26 to −0.16) and − 0.2% (95% CI –0.26 to −0.14) per year for overall MS from 1990 to 2019, respectively. The number of YLL globally in 2019 was 7,891 (5,003 to 10,991) and 15,667 (10,833 to 20,076) due to smoking-attributable MS. The age-standardized YLD and YLL rates decreased by an annual average of −1.14% (95% CI –1.25 to −1.04) and − 1.15% (95% CI –1.27 to −1.03) for MS attributable to smoking. Although the global age-standardized rates of YLD and YLL for MS among older adults declined from 1990 to 2019, many regions showed increases. The largest increase in age-standardized YLD rate of MS was observed in East Asia (average annual change 1.62% [95% CI: 1.56 to 1.68]), while the largest increase in the age-standardized YLL rate occurred in High-income North America (1.74% [1.53 to 1.96]). Nationally, the age-standardized YLD and YLL rates for overall and smoking-attributable MS increased exponentially with increases in SDI level (all model p < 0.001). Furthermore, projections have also indicated an expected decrease in the age-standardized rates of YLD and YLL of MS in the elderly population from 2020 to 2040.ConclusionTracking trends in MS burden among older adults provides insights into the potential shifts in disease patterns over time. The findings lay the groundwork for informed decision-making in public health and healthcare delivery, aiming to ensure that older adults with MS receive appropriate care and support.

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How different are late onset and adult onset MS really?

van den Heuvel

2024

Medicom Conference Report EAN 2024

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Multiple sclerosis in the elderly: a retrospective cohort study

Cited by 3 publications

References 68 publications

Impact of Cognitive Impairment on Quality of Life in Multiple Sclerosis Patients—A Comprehensive Review

Impact of Cognitive Impairment on Quality of Life in Multiple Sclerosis Patients—A Comprehensive Review

The overall and smoking-attributable burden of multiple sclerosis among older adults aged 65–89 years from 1990 to 2019 and predictions to 2040

How different are late onset and adult onset MS really?

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