Explor Neurosci 2023
DOI: 10.37349/en.2023.00020
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Multiple sclerosis with comorbidity depression and its association with vitamin D deficiency in a narrative review of the current literature

Hans-Klaus Goischke

Abstract: Over the past decade, knowledge of the pathophysiology and immunology of multiple sclerosis (MS) and depression, and the complex links to vitamin D (VitD) balance, has increased rapidly. Both diseases are characterized by an imbalance of proinflammatory and antiinflammatory cytokines, increased serum neurofilament light chains (sNfLs), disruption of the blood-brain barrier (BBB), abolition of the physiological function of the various types of microglia (MG), decreased calcidiol-serum levels, and disorders of t… Show more

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