1999
DOI: 10.1128/mcb.19.9.6164
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Multiple Signal Input and Output Domains of the 160-Kilodalton Nuclear Receptor Coactivator Proteins

Abstract: Members of the 160-kDa nuclear receptor coactivator family (p160 coactivators) bind to the conserved AF-2 activation function found in the hormone binding domains of nuclear receptors (NR) and are potent transcriptional coactivators for NRs. Here we report that the C-terminal region of p160 coactivators glucocorticoid receptor interacting protein 1 (GRIP1), steroid receptor coactivator 1 (SRC-1a), and SRC-1e binds the N-terminal AF-1 activation function of the androgen receptor (AR), and p160 coactivators can … Show more

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Cited by 229 publications
(228 citation statements)
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References 61 publications
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“…9) shows the regulatory effect of Zac1 on p21 gene and protein expression through p53-dependent and p53-independent pathways and protein-protein interactions with, at least, p53 and HDAC1 at the transcriptional level. In this article, the 1 Amol/L concentration is higher than the IC 50 TSA concentrations might be involved in the HDAC enzyme activity and/or DNA damage and response. Thus, it will be of great interest in the future to examine which mechanism is responsible for the induction of the p21 gene and protein by various TSA concentrations in HeLa cells.…”
Section: Discussionmentioning
confidence: 84%
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“…9) shows the regulatory effect of Zac1 on p21 gene and protein expression through p53-dependent and p53-independent pathways and protein-protein interactions with, at least, p53 and HDAC1 at the transcriptional level. In this article, the 1 Amol/L concentration is higher than the IC 50 TSA concentrations might be involved in the HDAC enzyme activity and/or DNA damage and response. Thus, it will be of great interest in the future to examine which mechanism is responsible for the induction of the p21 gene and protein by various TSA concentrations in HeLa cells.…”
Section: Discussionmentioning
confidence: 84%
“…Transient transfections and luciferase assays were done in 24-well culture dishes as described previously (50). Total DNA was adjusted to 1 Ag by adding each of the corresponding empty vectors.…”
Section: Cell Culture and Transient Transfection Assaysmentioning
confidence: 99%
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“…1A), the receptor interaction domains (RIDs) and the two activation domains (AD1 and AD2) have been found to be required for full coactivator activity (8). Amino acids 1057-1109 of TIF2/GRIP1 are within the AD1 domain and are required for CBP/p300 binding (8,40,41). This binding of CBP/p300 is thought to be particularly important for the coactivator activity of TIF2/GRIP1 because TIF2/GRIP1 does not possess any intrinsic HAT activity (8) but rather relies on the binding of CBP/p300 to provide HAT activity.…”
Section: Minimum Domain Of Coactivator Tif2/grip1 For Modulation Of Gmentioning
confidence: 99%
“…The p160 coactivators have multiple signal input domains that bind directly to hormone activated nuclear receptors and multiple signal output domains which recruit additional coactivators (Ma et al, 1999). The p160 coactivators have an intrinsic protein acetyltransferase activity and recruit additional coactivators such as CBP/p300 and p/CAF, which also possess protein acetyltransferase activities (Chen et al, 1997;Spencer et al, 1997).…”
Section: Arginine Methylationmentioning
confidence: 99%