Multiple signal transduction pathways alterations during nerve agent toxicity

Golime, RamaRao; Bhattacharya, B. K.

doi:10.1016/j.toxlet.2011.09.022

Cited by 25 publications

(21 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although CWNAs are an important category of CWAs, the extreme rapidity of their lethal effects in combination with the existence of effective therapeutics undermines the exploration of antioxidants as a primary CWNA therapeutics. However, survivors of CWNA exposures often have delayed neurologic symptoms of memory loss and cognitive dysfunction that may be amendable to antioxidant therapy[55]. …”

Section: 0 Overview Of the Evidence For Oxidative Stress In Cwas Anmentioning

confidence: 99%

Antioxidants as potential medical countermeasures for chemical warfare agents and toxic industrial chemicals

McElroy

Day

2016

Biochemical Pharmacology

View full text Add to dashboard Cite

The continuing horrors of military conflicts and terrorism often involve the use of chemical warfare agents (CWAs) and toxic industrial chemicals (TICs). Many CWA and TIC exposures are difficult to treat due to the danger they pose to first responders and their rapid onset that can produce death shortly after exposure. While the specific mechanism(s) of toxicity of these agents are diverse, many are associated either directly or indirectly with increased oxidative stress in affected tissues. This has led to the exploration of various antioxidants as potential medical countermeasures for CWA/TIC exposures. Studies have been performed across a wide array of agents, model organisms, exposure systems, and antioxidants, looking at an almost equally diverse set of endpoints. Attempts at treating CWAs/TICs with antioxidants have met with mixed results, ranging from no effect to nearly complete protection. The aim of this commentary is to summarize the literature in each category for evidence of oxidative stress and antioxidant efficacy against CWAs and TICs. While there is great disparity in the data concerning methods, models, and remedies, the outlook on antioxidants as medical countermeasures for CWA/TIC management appears promising.

show abstract

Section: 0 Overview Of the Evidence For Oxidative Stress In Cwas Anmentioning

confidence: 99%

Antioxidants as potential medical countermeasures for chemical warfare agents and toxic industrial chemicals

McElroy

Day

2016

Biochemical Pharmacology

View full text Add to dashboard Cite

show abstract

“…219 Although the gene expression (production) of these cytokines was greatly increased, the expression of the genes coding for their receptors was increased only slightly or in some cases decreased. Similar dysregulation of other cytokines, chemokines and proteases also occurred.…”

Section: Toxic Shock Syndrome (Tss)mentioning

confidence: 99%

“…Specifically, high levels of IFN-γ increased small-bowel permeability to macromolecules. 219 So, although there are no publications in the literature describing the long-term health effects of acute SEB intoxication at this time, the mechanisms for longer-term cytokine dysregulation as a result of SEB-induced TSS may continue to produce sub-clinical illness for some time after toxin and bacteria have been cleared.…”

Section: Toxic Shock Syndrome (Tss)mentioning

confidence: 99%

Assessment of Potential Long Term Health Effects on Army Human Test Subjects of Relevant Biological and Chemical Agents, Drugs, Medications and Substances

Johnson¹

2016

View full text Add to dashboard Cite

“…Otherwise, an augmented Ca 2+ influx through the NMDA receptor or VDCC can be responsible for the activation of lethal metabolic pathways. Different toxins and stress conditions [187–190] have been implicated in the regulation of intracellular Ca 2+ -dependent processes in cells, and different cell types exhibit a diverse range of transient responses to the same stimulus.…”

Section: Central Roles Of Ca2+ and Glutamate Receptors Mediating Tmentioning

confidence: 99%

Signaling Mechanisms and Disrupted Cytoskeleton in the Diphenyl Ditelluride Neurotoxicity

Pessoa-Pureur

Heimfarth

Rocha

2014

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Evidence from our group supports that diphenyl ditelluride (PhTe)2 neurotoxicity depends on modulation of signaling pathways initiated at the plasma membrane. The (PhTe)2-evoked signal is transduced downstream of voltage-dependent Ca2+ channels (VDCC), N-methyl-D-aspartate receptors (NMDA), or metabotropic glutamate receptors activation via different kinase pathways (protein kinase A, phospholipase C/protein kinase C, mitogen-activated protein kinases (MAPKs), and Akt signaling pathway). Among the most relevant cues of misregulated signaling mechanisms evoked by (PhTe)2 is the cytoskeleton of neural cells. The in vivo and in vitro exposure to (PhTe)2 induce hyperphosphorylation/hypophosphorylation of neuronal and glial intermediate filament (IF) proteins (neurofilaments and glial fibrillary acidic protein, resp.) in different brain structures of young rats. Phosphorylation of IFs at specific sites modulates their association/disassociation and interferes with important physiological roles, such as axonal transport. Disrupted cytoskeleton is a crucial marker of neurodegeneration and is associated with reactive astrogliosis and apoptotic cell death. This review focuses the current knowledge and important results on the mechanisms of (PhTe)2 neurotoxicity with special emphasis on the cytoskeletal proteins and their differential regulation by kinases/phosphatases and Ca2+-mediated mechanisms in developmental rat brain. We propose that the disrupted cytoskeletal homeostasis could support brain damage provoked by this neurotoxicant.

show abstract

Multiple signal transduction pathways alterations during nerve agent toxicity

Cited by 25 publications

References 71 publications

Antioxidants as potential medical countermeasures for chemical warfare agents and toxic industrial chemicals

Antioxidants as potential medical countermeasures for chemical warfare agents and toxic industrial chemicals

Assessment of Potential Long Term Health Effects on Army Human Test Subjects of Relevant Biological and Chemical Agents, Drugs, Medications and Substances

Signaling Mechanisms and Disrupted Cytoskeleton in the Diphenyl Ditelluride Neurotoxicity

Contact Info

Product

Resources

About