Multiple skeletal muscle metastases from poorly differentiated gastric adenocarcinoma

Koga, Yasutoshi; Baba, Yoshifumi; Harada, Kazuto; Kosumi, Keisuke; Shigaki, Hironobu; Kurashige, Junji; Ishimoto, Takatsugu; Iwatsuki, Masaaki; Miyamoto, Yuji; Sakamoto, Yasuo; Yoshida, Naoya; Baba, Hideo

doi:10.1186/s40792-015-0108-3

Cited by 12 publications

(12 citation statements)

References 20 publications

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“…We searched the PubMed database using the keywords of "gastric cancer, " "muscle metastasis, " and "muscular metastasis". We found six muscular metastases cases after curative gastrectomy (Table 2) [14][15][16][17][18][19]. The median age was 61 years (range 47-82 years) and all patients were male.…”

Section: Discussionmentioning

confidence: 99%

Metachronous port site, muscular and subcutaneous metastases from a gastric adenocarcinoma: a case report and review of articles

et al. 2021

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Background Port site metastasis (PSM) after curative gastrectomy for gastric cancer and muscular metastasis from gastric cancer are rare manifestations. Similarly, subcutaneous metastasis from gastric cancer is rare, and muscular and subcutaneous metastases are associated with poor prognosis. We report a case of long-term survival in a patient who underwent curative resection of gastric cancer and repeated recurrence of port site, muscular and subcutaneous metastases from gastric cancer, treated by resection. Case presentation A 75-year-old man was diagnosed with gastric cancer and referred to our department. Upper endoscopy demonstrated a 5-cm circumferential ulcerated lesion at the cardia. Biopsy findings showed a poorly differentiated tubular adenocarcinoma. He underwent laparoscopic total gastrectomy with lymph node dissection, and pathologic examination revealed a moderately differentiated tubular adenocarcinoma stage T4aN1M0 and IIIA according to the UICC (Union for International Cancer Control) classification. He refused adjuvant chemotherapy and was only carefully observed. Twenty-three months after the primary gastrectomy, computed tomography (CT) revealed an irregular mass near the port site wounds. Then the patient underwent mass resection, and the pathological diagnosis was consistent with metastatic adenocarcinoma, located in the subcutaneous tissue at the port site wounds. Thirteen months after the second surgery, CT revealed an enhanced mass in the abdominal wall. Positron emission tomography (PET) CT showed an elevated uptake in the rectus abdominis muscle and a standardized uptake value (SUV) of 3.1. The patient underwent another mass resection, and the pathological diagnosis was consistent with metastatic adenocarcinoma in the rectus abdominis muscle. Thirty-five months after the third surgery, CT revealed a mass in the left gluteal subcutaneous region. Furthermore, PET-CT revealed a 35-mm mass with an elevated SUV of 9.6. Another mass resection procedure was performed, and the pathological diagnosis was consistent with metastatic adenocarcinoma in the subcutaneous tissue. Since tumor cells were present at the resection margin, additional radiation therapy was performed. The patient has survived 78 months after primary gastrectomy. Conclusion The prognosis of muscular and subcutaneous metastases from gastric cancer is poor. However, if the metastatic tumor is solitary, surgical excision could be a feasible treatment option and might prolong survival.

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Section: Discussionmentioning

confidence: 99%

Metachronous port site, muscular and subcutaneous metastases from a gastric adenocarcinoma: a case report and review of articles

et al. 2021

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“…Our case is similar in presentation to the one by Koga et al . in that widespread muscle infiltration occurred in the absence of liver or lung involvement [16].…”

Section: Discussionmentioning

confidence: 99%

“…Prognosis remains poor namely due to the presence of a widely metastatic disease and lack of effective treatment modalities [16–17]. Treatment options include palliative chemotherapy, radiotherapy and surgical resection for symptomatic relief.…”

Section: Discussionmentioning

confidence: 99%

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Metastatic involvement of skeletal muscle from gastric adenocarcinoma

Aguirre

Salcedo

Zuquello

et al. 2019

Oxford Medical Case Reports

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Gastric cancer represents the fifth most common cancer diagnosis worldwide and the third leading cause of cancer-related mortality. In the USA, the overall 5-year survival rate is 31%, with distant disease nearing 5%. The most common sites of metastasis are the liver and peritoneum. Skeletal muscle involvement has been rarely reported. Since clinical and imaging findings overlap with primary sarcomas, a confirmatory biopsy is required for diagnosis. Prognosis remains poor with treatment options including palliative chemotherapy, radiotherapy and surgical resection. We report the case of a 57-year-old female presenting with extensive involvement of skeletal muscle 10 years after achieving remission. In addition to illustrating the refractoriness and poor outcomes associated with muscle involvement, this case and comprehensive review of the literature highlights important characteristics of disease biology and tumor genomics that warrant detailed discussion and exposition to a wider audience.

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“…We reviewed the reported cases of skeletal muscle metastasis from gastric cancer. To search the literature, we used key words of “gastric cancer (or carcinoma)” and “muscle (or musclar) metastasis (or metastases)”, and found five cases that had metachronous skeletal muscle metastasis without any other organ metastases after curative gastrectomy (Table 1 ) [ 2 , 7 – 10 ]. In detail, all cases were male, and median age was 60.5 years (range 47–75 years).…”

Section: Case Presentationmentioning

confidence: 99%

Metachronous skeletal muscle metastasis without any other organ metastases after curative gastrectomy: a case report

Kamitani

Watanabe²,

Kirihataya³

et al. 2018

surg case rep

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BackgroundSkeletal muscle metastasis from gastric cancer is extremely rare and often accompanied with synchronous metastasis to any other organs. We herein report a case of rapidly developing multiple skeletal metastases from gastric cancer without any other organ metastases.Case presentationA 47-year-old man underwent distal gastrectomy for advanced gastric cancer. Pathological diagnosis was poorly differentiated adenocarcinoma, T2N1M0, Stage IIA. The patient presented with a history of left dorsal tenderness 12 months after the operation. A computed tomography (CT) revealed a solid mass in the left latissimus dorsi muscle. Pathological examination of the ultrasound guided needle biopsy specimen revealed poorly differentiated adenocarcinoma similar to the previously resected gastric cancer, and the tumor was diagnosed as metastasis of gastric cancer. Thereafter, the systemic chemotherapy was administrated. However, the metastases were extended to the paraspinal muscle and quadriceps, and the patient died 7 months after the recurrence.ConclusionsThe prognosis of patients with skeletal muscle metastasis may be extremely poor, even in patients without any other organ metastases. The development of further chemotherapeutic agents and regimens is therefore needed.

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Multiple skeletal muscle metastases from poorly differentiated gastric adenocarcinoma

Cited by 12 publications

References 20 publications

Metachronous port site, muscular and subcutaneous metastases from a gastric adenocarcinoma: a case report and review of articles

Metachronous port site, muscular and subcutaneous metastases from a gastric adenocarcinoma: a case report and review of articles

Metastatic involvement of skeletal muscle from gastric adenocarcinoma

Metachronous skeletal muscle metastasis without any other organ metastases after curative gastrectomy: a case report

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