Multiple small, rectal neuroendocrine tumors with numerous micronests

Park, Sung Chan; Han, Nayoung; Lee, Jihyeon; Chang, Hee Jin; Oh, Jae Hwan; Sohn, Dae Kyung

doi:10.1111/1751-2980.12645

Cited by 5 publications

(10 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the Japanese population, rectal NET is the most frequently reported GI tract NET (1). To date, only a few reports of multiple rectal NETs associated with multiple ECMs have been published (2,3,5,6). ECMs may be regarded as the initial phase or intermediate stage of development of a carcinoid tumor (3).…”

Section: Discussionmentioning

confidence: 99%

“…In Japan, rectal NET is the most common GI tract NET (1). While most rectal NET cases are single tumor lesions, some studies have reported multiple tumor lesions (2)(3)(4)(5). The lesions described in these reports were less than 1 cm in diameter, although the exact size was not mentioned.…”

Section: Introductionmentioning

confidence: 94%

“…In the stomach, such micronests are known as endocrine cell micronests (ECM). However, only a few reports of ECMs have been reported in the colorectum (2,3,5,6), and their significance has not been clarified.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Single Rectal Neuroendocrine Tumor Associated with Multiple Endocrine Cell Micronests

et al. 2020

View full text Add to dashboard Cite

Although a few reports of neuroendocrine tumor (NET) in the stomach or appendix with surrounding micronests have been published, cases of rectal NET are rare. We herein report a unique case of a patient with single rectal NET treated endoscopically. A pathological examination revealed multiple endocrine cell micronests (ECMs) in the submucosal layer around the main NET lesion. Neither lymph node metastasis nor distant metastasis in computed tomography was observed six years after the treatment. Because case reports of multiple ECM are very rare, the significance of malignancy is unclear. It therefore appears to be necessary to accumulate similar cases.A 53-year-old man with no remarkable medical history of major illness and family history was referred to our hospital for endoscopic treatment of SMT in the rectum. Colonoscopy revealed a yellowish-white rectal SMT approximately 4 mm in diameter.The lesion did not show any irregularity of the vessels, irregularity of the surface pattern, or depression (Fig. 1). Endoscopic ultrasonography (EUS) (20 MHz, UM-DP20-25R;

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

See 1 more Smart Citation

Single Rectal Neuroendocrine Tumor Associated with Multiple Endocrine Cell Micronests

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Most of rectal NETs are single; multiple neuroendocrine tumors (M-NETs) are rare. It is reported that the incidence of rectal M-NETs is between 2% and 4.5% ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

“…There are no specific physical exams and lab results for M-NETs. The choice of treatment for rectal NETs depends on the size of the tumors, the depth of invasion and the presence of distant metastasis ( 3 ). However, due to the rarity of rectal M-NETs, most of the literature related to M-NETs in the past appeared in the form of case reports.…”

Section: Introductionmentioning

confidence: 99%

Multiple rectal neuroendocrine tumors: An analysis of 15 cases and literature review

et al. 2022

View full text Add to dashboard Cite

Multiple neuroendocrine tumors (M-NETs) are rare in the rectum and there is no consensus on their characteristics and treatments. Here, we report 15 cases of rectal M-NETs and review the previous literature. We discuss the clinical characteristics, endoscopic features and pathological features of rectal M-NETs, aiming to analyze the treatments and follow-up strategies in combination with these characteristics. We retrospectively reviewed and analyzed the data of 15 patients with rectal M-NETs who were diagnosed and treated at Beijing Friendship Hospital, Capital Medical University. Their clinical data, endoscopic findings, pathological features and treatments were analyzed. Follow-up evaluations and literature review were performed. In all, 14 male (93.3%) and 1 female (6.7%) were recruited. The average age at diagnosis was 55.7 years. The clinical manifestations include asymptomatic in 9 patients (60.0%), defecation habits changes in 2 patients (13.3%), anal distension in 2 patients (13.3%), and abdominal distension in 2 patient (13.3%). The largest tumor diameter ≤10mm was found in 13 patients (86.7%) and >10mm in 2 patients (13.3%). All of the lesions originated from the mucous or submucosa layer. WHO grades were all NET G1. The number of tumors diagnosed by pathology in 13 patients was consistent with that observed by endoscopy, while more lesions were observed by pathology than endoscopy in two patients. Lymph node metastasis occurred in 1 patient (6.7%), and vascular or lymphatic invasion occurred in 9 patients (60.0%). Among the 13 patients with the largest tumor diameter being ≤10mm, lymphovascular invasion occurred in 8 patients (61.5%). And among the 2 patients with the largest tumor diameter of >10mm, lymphovascular invasion occurred in 1 patient (50.0%). 14 patients underwent endoscopic resection and 1 underwent surgical excision. Postoperative follow-up was achieved in 13 patients and no recurrence or metastasis was found. The true number of rectal M-NETs may be more than seen under endoscopy. Rectal M-NETs is associated with a high risk of metastasis; therefore, treatment and surveillance strategies should be more radical than single lesion.

show abstract

Clinicopathological characteristics of rectal multiple neuroendocrine neoplasms and literature review

Zheng

et al. 2023

BMC Surg

View full text Add to dashboard Cite

Background There are only a few epidemiological reports available for reference. The clinicopathological features are not clear, so there is no consensus on treating rectal multiple neuroendocrine neoplasms. This study aims to summarize the clinicopathological characteristics and preliminarily discuss the clinical diagnosis and treatment of rectal multiple neuroendocrine neoplasms. Methods This study retrospectively analyzed rectal neuroendocrine neoplasm patients diagnosed and treated at the Fourth Hospital of Hebei Medical University from February 2007 to May 2021. The clinicopathological characteristics of rectal multiple neuroendocrine neoplasms were summarized and analyzed in combination with 14 studies on rectal multiple neuroendocrine neoplasms. Results The incidence of RM-NENs accounted for 3.8% of all R-NENs in this study. The number of tumors varied to some extent, the size of tumors was basically no more than 10 mm, and there were more G1 grade tumors. In the analysis of 46 cases with known lymph node metastasis, the difference in lymph node metastasis rate between the number of tumors < 8 and ≥ 8 was statistically significant (p = 0.002). Conclusions The incidence of rectal multiple neuroendocrine neoplasms accounted for 3.8% of all rectal neuroendocrine neoplasms. For rectal multiple neuroendocrine neoplasms, the lymph node metastasis rate was higher when the number of tumors was ≥ 8. The influence of the number of tumors on lymph node metastasis should be considered in the selection of treatment.

show abstract

Multiple small, rectal neuroendocrine tumors with numerous micronests

Cited by 5 publications

References 13 publications

Single Rectal Neuroendocrine Tumor Associated with Multiple Endocrine Cell Micronests

Single Rectal Neuroendocrine Tumor Associated with Multiple Endocrine Cell Micronests

Multiple rectal neuroendocrine tumors: An analysis of 15 cases and literature review

Clinicopathological characteristics of rectal multiple neuroendocrine neoplasms and literature review

Contact Info

Product

Resources

About