Multiple‐Stimuli Responsive and Tunable Luminescent Supramolecular Assembly by Oligo(<i>p</i>‐phenylvinylene) and Surfactant

Chen, Xu‐Man; Chen, Yong; Liu, Yu

doi:10.1002/cjoc.201800063

Cited by 10 publications

(4 citation statements)

References 45 publications

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“…As shown in Figure 5a,b, when the temperature gradually increased from 15 to 70°C, the optical transmittance of PEHA‐β‐CD‐FA/SDS NPs gradually increased, which indicated that PEHA‐β‐CD‐FA/SDS NPs were disassembled. The reason for PEHA‐β‐CD‐FA/SDS NPs depolymerization can be interpreted by the fact that the temperature (70°C) of nanoparticles exceeds the lower critical solution temperature (LCST), 38 which makes the nanoparticles undergo a phase transition and the electrostatic force weakens, eventually leading to nanoparticle collapse 39 . Furthermore, when the temperature of PEHA‐β‐CD‐FA/SDS NPs gradually decreased from 70 to 15°C, the optical transmittance gradually decreased, indicating that PEHA‐β‐CD‐FA/SDS NPs were gradually assembled.…”

Section: Resultsmentioning

confidence: 99%

A dual‐stimuli responsive supramolecular nanovector anchoring folic acid ligands for targeted delivery of anti‐colorectal drug hydroxycamptothecin

Teng

Chen

et al. 2022

J of Applied Polymer Sci

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Hydroxycamptothecin (HCPT) is a first-line anti-colorectal cancer chemotherapeutic agent. Nevertheless, the poor tumor-specific delivery properties of HCPT make it indiscriminate in killing normal and cancer cells, as well as impossible to achieve sustained treatment due to its low cumulative concentration in cancer cells. Here, a pH and temperature co-responsive supramolecular nanocarrier anchoring with folic acid (FA) ligands, termed PEHA-β-CD-FA/SDS NPs, was prepared based on electrostatic interaction between cationic mono-(6-pentaethylenehexamine)-β-CD (PEHA-β-CD-FA) and anionic sodium dodecyl sulfate (SDS). PEHA-β-CD-FA/SDS NPs exhibited assembly/disassembly behavior accompanied by co-regulation of temperature and pH and are therefore employed as nanocarriers to load, deliver, and release HCPT. Notably, the release rate of HCPT achieved 93.6% at pH = 8.5 and T = 45 C which simulates the microenvironment of colon cancer cells. Cell biology experiments demonstrated that the more precise targeting ability of HCPT-loaded NPs resulted in higher cytotoxicity to tumor cells but also less toxicity to normal cells BEAS-2B. Flow cytometry apoptosis analysis also demonstrated that HCPT-loaded NPs had a significant growth-inhibitory effect on SW480 colon cancer cells. We expected that the supramolecular nanoparticles combining active and passive targeting capabilities could be further developed as potential drug carrier formulations for enhancing the clinical efficacy of anti-colon cancer drugs.

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Section: Resultsmentioning

confidence: 99%

A dual‐stimuli responsive supramolecular nanovector anchoring folic acid ligands for targeted delivery of anti‐colorectal drug hydroxycamptothecin

Teng

Chen

et al. 2022

J of Applied Polymer Sci

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“…By a similar strategy, Pd‐catalyzed intramolecular aminofluorination of allylic sulfamides ( 36 ) with AgF/PhI(OPiv) 2 furnished a variety of fluorinated cyclic sulfamide derivatives ( 37 ) (Scheme ) . Acetic acid played a crucial role in improving the reactivity to give reasonable yields of the major 6‐ endo cyclization products.…”

Section: Fluorination Mediated By Hypervalent Iodine Reagentsmentioning

confidence: 99%

Fluorination and Fluoroalkylation Reactions Mediated by Hypervalent Iodine Reagents

Han

Zhang

2020

Adv Synth Catal

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This review summarizes the progress in the fluorination and fluoroalkylation of electron-rich systems with diverse fluorine (F) and fluoroalkyl (R fn) reagents employing hypervalent iodine compounds as initiators in the last few decades. Because of the strong electrophilicity, high oxidizing properties, low toxicity, air and moisture stability, ready availability, ease of handling, and mild reaction conditions, the hypervalent iodine reagents have been widely utilized in modern organic chemistry. In particular, the use of hypervalent iodine reagents to initiate the CÀ F and CÀ R fn (R fn =CF 2 H, CF 3 , perfluoroalkyl, OCH 2 CF 3 , SCF 3 , SeCF 3 and etc) bond formation has been increasingly developed. In these reactions, hypervalent iodine compounds behave as powerful oxidants or electrophiles and activate the fluorination/fluoroalkylation reagents, the transitionmetal catalysts, or the substrates to in situ form electrophilic or radical intermediates, which subsequently participate in fluorination, difluoromethylation, trifluoromethylation, perfluoroalkylation, trifluoroethoxylation, fluoroalkylthiolation, trifluoromethylselenolation and others under mild conditions. Although great achievements have been made in this area, they are just the initial phase and still require a wide scope for improvement. It is anticipated that this review will draw much attention from the organic chemistry community and inspire more contributions in the development of new hyper-valent-iodine-mediated fluorination and fluoroalkylation reactions.

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“…The reaction was successfully carried out also on alkenyl sulfamides. 60 Using pentenylureas 75 instead of N-tosyl derivatives 73 with the same catalytic system, Liu achieved a selective 5exo-trig-cyclization (Scheme 46). 61 Urea acts as chelating protecting group and the addition of hexafluoroisopropyl alcohol is essential in order to achieve highly selective fluorination.…”

Section: Pd(ii)/pd(iv)mentioning

confidence: 99%

Intramolecular Oxidative Palladium-Catalyzed Amination Involving Double C–H Functionalization of Unactivated Olefins

et al. 2017

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Intramolecular palladium-catalyzed amination reactions are becoming important tools for the synthesis of various nitrogen-containing heterocycles. This account highlights the developments achieved in this field by domino processes in oxidative conditions using unactivated olefins, due to their advantages in terms of step economy and efficiency. These reactions involve the change of oxidation state in the palladium intermediate, requiring the presence of an oxidizing agent to regenerate the catalytic cycle. This kind of additive is essential for the success of the reaction and it can also furnish nucleophilic species that are incorporated into the final product. Reactions can occur at either the intra/intra- or intra/intermolecular level, providing valuable methodologies for the preparation of (poly)heterocyclic scaffolds. Besides, procedures based on the use of strengthened catalytic systems, more recently, disclosed intriguing conditions have enlarged the possibility to modulate the substrate reactivity. Perspectives in this field are directed to the discovery of new reaction conditions, focusing on the employment of oxidatively stable ligands useful for the asymmetric catalysis.1 Introduction2 Carboamination Reactions2.1 Pd(0)/Pd(II)2.2 Pd(II)/Pd(IV)3 Aminooxygenation Reactions3.1 Pd(0)/Pd(II)3.2 Pd(II)/Pd(IV)4 Diamination Reactions4.1 Pd(0)/Pd(II)4.2 Pd(II)/Pd(IV)5 Aminohalogenation Reactions5.1 Pd(0)/Pd(II)5.2 Pd(II)/Pd(IV)6 Conclusions

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Multiple‐Stimuli Responsive and Tunable Luminescent Supramolecular Assembly by Oligo(p‐phenylvinylene) and Surfactant

Cited by 10 publications

References 45 publications

A dual‐stimuli responsive supramolecular nanovector anchoring folic acid ligands for targeted delivery of anti‐colorectal drug hydroxycamptothecin

A dual‐stimuli responsive supramolecular nanovector anchoring folic acid ligands for targeted delivery of anti‐colorectal drug hydroxycamptothecin

Fluorination and Fluoroalkylation Reactions Mediated by Hypervalent Iodine Reagents

Intramolecular Oxidative Palladium-Catalyzed Amination Involving Double C–H Functionalization of Unactivated Olefins

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