Multiple Supratemporal Sources of Magnetic and Electric Auditory Evoked Middle Latency Components in Humans

Yvert, Blaise; Crouzeix, A.; Bertrand, Olivier; Seither-Preisler, Annemarie; Pantev, Christo

doi:10.1093/cercor/11.5.411

Cited by 178 publications

(126 citation statements)

References 71 publications

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“…The modulation of the ERPs by sequential predictability occurred at a very early time range, which corresponds to the auditory middle latency responses (Yvert et al, 2001). During the first 50 ms from the expected onset of the tone, the course of the ERP elicited by the omission of a fully predictable tone resembled that elicited by the actual tone presentation.…”

Section: Discussionmentioning

confidence: 77%

I Heard That Coming: Event-Related Potential Evidence for Stimulus-Driven Prediction in the Auditory System

Bendixen

Schröger

Winkler³

2009

Journal of Neuroscience

193

154

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The auditory system has been shown to detect predictability in a tone sequence, but does it use the extracted regularities for actually predicting the continuation of the sequence? The present study sought to find evidence for the generation of such predictions. Predictability was manipulated in an isochronous series of tones in which every other tone was a repetition of its predecessor. The existence of predictions was probed by occasionally omitting either the first (unpredictable) or the second (predictable) tone of a same-frequency tone pair. Event-related electrical brain activity elicited by the omission of an unpredictable tone differed from the response to the actual tone right from the tone onset. In contrast, early electrical brain activity elicited by the omission of a predictable tone was quite similar to the response to the actual tone. This suggests that the auditory system preactivates the neural circuits for expected input, using sequential predictions to specifically prepare for future acoustic events.

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Section: Discussionmentioning

confidence: 77%

I Heard That Coming: Event-Related Potential Evidence for Stimulus-Driven Prediction in the Auditory System

Bendixen

Schröger

Winkler³

2009

Journal of Neuroscience

193

154

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“…Because of intrinsic limitations in MEG spatial resolution, MEG probably will not be able to provide substantial insight into which of these mechanisms, if any, may contribute to the observed deficit. However, there are components in the auditory evoked magnetic field that are generated by primary auditory cortex (Lutkenhoner et al, 2003, Pantev et al, 1995, Yvert et al, 2001. A future study focusing on such signals could therefore examine population frequency tuning of units that are more likely to have sharper tuning curves, at least in healthy individuals.…”

Section: Discussionmentioning

confidence: 99%

Neuromagnetic evidence of broader auditory cortical tuning in schizophrenia

Rojas

Slason

Teale

et al. 2007

Schizophrenia Research

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Deficits in basic auditory perception have been described in schizophrenia. Previous electrophysiological imaging research has documented a structure-function disassociation in the auditory system and altered tonotopic mapping in schizophrenia. The present study examined auditory cortical tuning in patients with schizophrenia.Eighteen patients with schizophrenia and 15 comparison subjects were recorded in a magnetoencephalographic (MEG) experiment of auditory tuning. Auditory cortical tuning at 1 kHz was examined by delivering 1 kHz pure tones in conjunction with pure tones at 5 frequencies surrounding and including 1 kHz. Source reconstruction data were examined for evidence of frequency specificity for the M100 component.There was a significant broadening of tuning in the schizophrenia group evident for the source amplitude of the M100. The frequently reported reduction in anterior-posterior source asymmetry for individuals with schizophrenia was replicated in this experiment. No relationships between symptom severity ratings and MEG measures were observed.This finding suggests that the frequency specificity of the M100 auditory evoked field is disturbed in schizophrenia, and may help explain the relatively poor behavioral performance of schizophrenia patients on simple frequency discrimination tasks. KeywordsMagnetoencephalography; Evoked Potentials; Auditory Cortex; Mental Illness; N100; M100 Corresponding Author: Donald C. Rojas, Ph.D. Box C268−68 CPH Rm 2J10 4200 E. 9th Avenue Denver, CO 80262 Phone: (303) 315 −8624 FAX: (303) 315−5641 email: Don.Rojas@uchsc.edu. Contributors D.C.R designed the study, performed the statistical analysis and wrote the manuscript. E.S. contributed data analyses and preliminary statistical analyses. P.D.T. contributed to the design of the experiment and selection of data analytic strategies and M.L.R. had substantial input on clinical aspects of the design, including selection and implementation of schizophrenia diagnostic and clinical measures appearing in the paper. All authors have contributed to and approved the final manuscript.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Conflict of InterestAll authors declare that they have no conflicts of interest with respect to this manuscript. NIH Public Access IntroductionThe M100 auditory evoked field has been reported to show anomalous anterior-posteior source location asymmetry in actively psychotic patients with paranoid schizophrenia. In normal adults, the neuroanatomical source of the M100 component is further anterior in the right hemisphere (Baumann et al., 1991). We and ...

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“…The auditory ERP N1, does not reflect a single underlying cerebral process, but it appears to contain both stimulus-specific and stimulus-nonspecific components, closely following the P1 component (Yvert et al 2001;Hamm et al 2013). These ERP components reflect sensory and perceptual processes.…”

Section: Introductionmentioning

confidence: 90%

The development of the N1 and N2 components in auditory oddball paradigms: a systematic review with narrative analysis and suggested normative values

et al. 2014

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Auditory event-related potentials (AERPs) are widely used in diverse fields of today's neuroscience, concerning auditory processing, speech perception, language acquisition, neurodevelopment, attention and cognition in normal aging, gender, developmental, neurologic and psychiatric disorders. However, its transposition to clinical practice has remained minimal. Mainly due to scarce literature on normative data across age, wide spectrum of results, variety of auditory stimuli used and to different neuropsychological meanings of AERPs components between authors. One of the most prominent AERP components studied in last decades was N1, which reflects auditory detection and discrimination. Subsequently, N2 indicates attention allocation and phonological analysis. The simultaneous analysis of N1 and N2 elicited by feasible novelty experimental paradigms, such as auditory oddball, seems an objective method to assess central auditory processing. The aim of this systematic review was to bring forward normative values for auditory oddball N1 and N2 components across age. EBSCO, PubMed, Web of Knowledge and Google Scholar were systematically searched for studies that elicited N1 and/or N2 by auditory oddball paradigm. A total of 2,764 papers were initially identified in the database, of which 19 resulted from hand search and additional references, between 1988 and 2013, last 25 years. A final total of 68 studies met the eligibility criteria with a total of 2,406 participants from control groups for N1 (age range 6.6-85 years; mean 34.42) and 1,507 for N2 (age range 9-85 years; mean 36.13). Polynomial regression analysis revealed that N1 latency decreases with aging at Fz and Cz, N1 amplitude at Cz decreases from childhood to adolescence and stabilizes after 30-40 years and at Fz the decrement finishes by 60 years and highly increases after this age. Regarding N2, latency did not covary with age but amplitude showed a significant decrement for both Cz and Fz. Results suggested reliable normative values for Cz and Fz electrode locations; however, changes in brain development and components topography over age should be considered in clinical practice.

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Multiple Supratemporal Sources of Magnetic and Electric Auditory Evoked Middle Latency Components in Humans

Cited by 178 publications

References 71 publications

I Heard That Coming: Event-Related Potential Evidence for Stimulus-Driven Prediction in the Auditory System

I Heard That Coming: Event-Related Potential Evidence for Stimulus-Driven Prediction in the Auditory System

Neuromagnetic evidence of broader auditory cortical tuning in schizophrenia

The development of the N1 and N2 components in auditory oddball paradigms: a systematic review with narrative analysis and suggested normative values

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