Multiple system atrophy with anti-NAE antibody refractory to immunotherapy: A case report

Ozawa, Masakazu; Sakuta, Kenichi; Miyagawa, Shuji; Yaguchi, Hiroshi

doi:10.1016/j.clineuro.2022.107504

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…47 However, a case report showed it was refractory to intravenous immunoglobulin therapy for NAE-associated MSA. 48 As mentioned above, α-enolase is multifunctional and also functions as a plasminogen receptor on the surface of cells and is involved in the immune response. Plasmin has the ability to promote proteolytic cleavage of extracellular α-synuclein, which is also a major component of the glial cytoplasmic inclusion body of MSA.…”

Section: Immunotherapy-responsible Anti-nae Antibody-associated Neuro...mentioning

confidence: 99%

“…Moreover, a single‐center, open‐label, pilot clinical trial reported that 6 mos of intravenous immunoglobulin therapy was effective in treating clinical manifestations of MSA; however, that report did not measure serum anti‐NAE antibodies 47 . However, a case report showed it was refractory to intravenous immunoglobulin therapy for NAE‐associated MSA 48 …”

Section: Anti‐nae Antibodies As a Potential Disease‐modyfing Factormentioning

confidence: 99%

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Expanding clinical spectrum from Hashimoto's encephalopathy to anti‐NAE antibody‐associated disorders (NAEAD)

Matsunaga,

Ikawa,

Yoneda

2023

Clinical & Exp Neuroim

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Using proteomic analysis, we identified anti‐NAE antibodies (autoantibodies against NH2‐terminal of alpha‐enolase) as a diagnostic marker for Hashimoto's encephalopathy (HE). As cases of HE with serum anti‐NAE antibodies accumulated, the clinical spectrum of HE with anti‐NAE antibodies became expanded. In addition, it is now known that antibodies can be detected in other diseases that differ from conventional HE. We recently reported the detection of anti‐NAE antibodies in patients with a clinical diagnosis of multiple system atrophy or corticobasal syndrome. These findings suggest that anti‐NAE antibodies indicate an immune mechanism in the pathogenesis of neurodegenerative diseases. We propose a novel disease concept for anti‐NAE antibody‐associated disorders (NAEAD). The clinical spectrum of NAEAD is not limited to HE but is a broad spectrum that partially shares several autoimmune neurological diseases, including autoimmune acute encephalopathy, autoimmune cerebellar ataxia, and autoimmune psychosis, and even extends to immune‐associated neurodegenerative diseases.

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Section: Immunotherapy-responsible Anti-nae Antibody-associated Neuro...mentioning

confidence: 99%

Section: Anti‐nae Antibodies As a Potential Disease‐modyfing Factormentioning

confidence: 99%

Expanding clinical spectrum from Hashimoto's encephalopathy to anti‐NAE antibody‐associated disorders (NAEAD)

Matsunaga,

Ikawa,

Yoneda

2023

Clinical & Exp Neuroim

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Steroid-responsive ocular flutter with truncal ataxia and anti-amino-terminal of α-enolase antibody

et al. 2023

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Autoimmune encephalitis and paraneoplastic neurological syndromes presenting atypical parkinsonism: a scoping review

2023

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Multiple system atrophy with anti-NAE antibody refractory to immunotherapy: A case report

Cited by 3 publications

References 5 publications

Expanding clinical spectrum from Hashimoto's encephalopathy to anti‐NAE antibody‐associated disorders (NAEAD)

Expanding clinical spectrum from Hashimoto's encephalopathy to anti‐NAE antibody‐associated disorders (NAEAD)

Steroid-responsive ocular flutter with truncal ataxia and anti-amino-terminal of α-enolase antibody

Autoimmune encephalitis and paraneoplastic neurological syndromes presenting atypical parkinsonism: a scoping review

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