Multiple-unit tablet of probiotic bacteria for improved storage stability, acid tolerability, and in vivo intestinal protective effect

Park, Hee-Jun; Lee, Ga Hyeon; Jun, Joon-Ho; Son, Miwon; Kang, Myung Joo

doi:10.2147/dddt.s103894

Cited by 6 publications

(2 citation statements)

References 37 publications

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“…This tablet was able to provide bacterial viability for 6 months at room conditions and was able to withstand ambient conditions better than uncoated strains. It was also found that the tablets exhibited sufficient tablet hardness and disintegration time [80].…”

Section: Different Approaches To Oral Pharmabiotic Tabletsmentioning

confidence: 88%

Oral pharmabiotic tablet formulations

KANDUR,

UĞURLU,

RAYAMAN

et al. 2024

jrp

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Pharmabiotic is a unique and recent term used to describe formulations containing probiotics. Pharmabiotics are probiotics prepared in a pharmaceutical form used to treat diseases and disorders by making physicochemical changes in human health. Probiotics, prebiotics, and synbiotics are included in this scope, and enzobiotics, which are a rising class of supplements, should be evaluated in this context, as they are a subspecies of synbiotics. Pharmabiotics, unlike nutribiotics, do not necessarily contain live microorganisms. The best examples of these are paraprobiotics and postbiotics. Tablet formulations are suitable dosage forms for pharmabiotics due to their redundant superiority over other solid dosage forms. Tablets are frequently preferred because they can be produced at low cost, are easily transported, and modified, are suitable for large-scale production, and are more stable than other dosage forms. Considering the examples in the literature and the definition of pharmabiotic, several tablet formulations can be mentioned as pharmabiotics. They can be divided into conventional uncoated tablets, chewable tablets, and effervescent tablets. With recent studies, this classification has expanded, and buccal mucoadhesive tablets, ODTs (orally disintegrating tablets) and FDTs (fast disintegrating tablets), layered/multi-layered tablets, and tablets within tablets have also taken their place in the classification. This article focuses on oral tablet formulations that can be classified as pharmabiotics.

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Section: Different Approaches To Oral Pharmabiotic Tabletsmentioning

confidence: 88%

Oral pharmabiotic tablet formulations

KANDUR,

UĞURLU,

RAYAMAN

et al. 2024

jrp

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“…Probiotics are used as a premix in admixture with animal feed. Probiotic cultures are exposed to external effects not only during the preparation of feed but also during the application of compositions, which result in a further reduction in the number of germs [2,3]. When introduced into the digestive tract, probiotic bacteria are exposed to the acidic action of gastric juice and bile acids that reduce the viability of bacterial cells [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Role and Effectiveness of Chitosan Coating on Probiotic Microcapsules

et al. 2022

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Microencapsulation and coating are preferred methods to increase the viability of the probiotic strains. The effect of microencapsulation technologies and materials used as microcapsule cores on viability is being investigated during development. In the present study, chitosan-coated and Eudragit L100-55-coated alginate microspheres were produced to encapsulate Lactobacillus plantarum probiotic bacteria. After the heat loading and simulated gastrointestinal juice dissolution study, the differences in viability were compared based on the CFU/mL values of the samples. The kinetics of the bacterial release and the ratio of the released live/dead cells of Lactobacillus plantarum were examined by flow cytometry. In all cases, we found that the CFU value for the chitosan-coated samples was virtually zero. The ratio of live/dead cells in the 120 min samples was significantly reduced to less than 20% for chitosan, while it was nearly 90% in the uncoated and Eudragit L100-55-coated samples. In the case of chitosan, based on some published MIC values and the amount of chitosan coating determined in the present study, we concluded the reason for our results. It was the first time to determine the amount of the released chitosan coat of the dried microcapsule, which reached the MIC value during the dissolution studies.

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Enhancing cadmium phytoremediation of Chlorophytum comosum (Thunb.) Jacques by applying cadmium-resistant bacterial tablet

Ketaubon,

Prapagdee

2023

Environ Sci Pollut Res

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Multiple-unit tablet of probiotic bacteria for improved storage stability, acid tolerability, and in vivo intestinal protective effect

Cited by 6 publications

References 37 publications

Oral pharmabiotic tablet formulations

Oral pharmabiotic tablet formulations

Investigation of the Role and Effectiveness of Chitosan Coating on Probiotic Microcapsules

Enhancing cadmium phytoremediation of Chlorophytum comosum (Thunb.) Jacques by applying cadmium-resistant bacterial tablet

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