Multiple valence states of Fe boosting SERS activity of Fe3O4 nanoparticles and enabling effective SERS-MRI bimodal cancer imaging

Lin, Jie; Ma, Xuehua; Li, Anran; Akakuru, Ozioma Udochukwu; Pan, Chunshu; He, Meng; Yao, Changliang; Ren, Wenzhi; Li, Yanying; Zhang, Dinghu; Cao, Yi; Chen, Tianxiang; Wu, Aiguo

doi:10.1016/j.fmre.2022.04.018

Cited by 7 publications

(7 citation statements)

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“…In vitro and in vivo studies have already been conducted using substoichiometric tungsten oxide (WOx) nanostructures coated with biocompatible substances 157 . Lin et al 158 have optimized Fe 3 O 4 nanoparticles that possess excellent SERS activity and can probe up to 5*10 -9 M concentration of crystal violet. They have optimized the design of the Fe 3 O 4 -based bioprobe in such a way that they can perform dual-mode cancer imaging using SERS and MRI 158 .…”

Section: Raman Probes For Theranosticsmentioning

confidence: 99%

“…Lin et al 158 have optimized Fe 3 O 4 nanoparticles that possess excellent SERS activity and can probe up to 5*10 -9 M concentration of crystal violet. They have optimized the design of the Fe 3 O 4 -based bioprobe in such a way that they can perform dual-mode cancer imaging using SERS and MRI 158 . With a Fe 3 O 4 -based bioprobe, subtypes of cancer cells were successfully identified with high sensitivity and specificity in vitro via high-resolution SERS imaging.…”

Section: Raman Probes For Theranosticsmentioning

confidence: 99%

“…With a Fe 3 O 4 -based bioprobe, subtypes of cancer cells were successfully identified with high sensitivity and specificity in vitro via high-resolution SERS imaging. The capability to probe a tumor at an early stage using a unique bioprobe with dual-modal imaging capability is crucial for detecting and treating cancers 158 . Metal oxides can be used for oncological imaging in vitro because they have the potential to show excellent SERS activity, which can be utilized to differentiate between cancerous and normal cells.…”

Section: Raman Probes For Theranosticsmentioning

confidence: 99%

“…Metal oxides can be used for oncological imaging in vitro because they have the potential to show excellent SERS activity, which can be utilized to differentiate between cancerous and normal cells. They can also be used as a high-potential contrast agent for T1-weighted MRI, enabling active-targeted imaging of tumor tissues in vivo 158 . Among various metal oxides, the NPs of iron oxide are the first generation of nanomaterials approved by the food and drug administration for their use in bioimaging, i.e., MRI, for the treatment of iron deficiency 159 .…”

Section: Raman Probes For Theranosticsmentioning

confidence: 99%

“…The significant Raman signature bands are at around 1255 cm -1 (C=O stretching) and 1325 cm -1 (CC stretching) observed for targeted tumor cells. Figure reprinted from 158 with permission. Copyright (2022) Fundamental Research.…”

Section: Figurementioning

confidence: 99%

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Emergence of Raman Spectroscopy as a Probing Tool for Theranostics

Singh¹,

Yadav²,

Dhillon³

et al. 2023

Nanotheranostics

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Although medical advances have increased our grasp of the amazing morphological, genetic, and phenotypic diversity of diseases, there are still significant technological barriers to understanding their complex and dynamic character. Specifically, the complexities of the biological systems throw a diverse set of challenges in developing efficient theranostic tools and methodologies that can probe and treat pathologies. Among several emerging theranostic techniques such as photodynamic therapy, photothermal therapy, magnetic resonance imaging, and computed tomography, Raman spectroscopy (RS) is emerging as a promising tool that is a label-free, cost-effective, and non-destructive technique. It can also provide real-time diagnostic information and can employ multimodal probes for detection and therapy. These attributes make it a perfect candidate for the analytical counterpart of the existing theranostic probes. The use of biocompatible nanomaterials for the fabrication of Raman probes provides rich structural information about the biological molecules, cells, and tissues and highly sensitive information down to single-molecule levels when integrated with advanced RS tools. This review discusses the fundamentals of Raman spectroscopic tools such as surface-enhanced Raman spectroscopy and Resonance Raman spectroscopy, their variants, and the associated theranostic applications. Besides the advantages, the current limitations, and future challenges of using RS in disease diagnosis and therapy have also been discussed.

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Section: Raman Probes For Theranosticsmentioning

confidence: 99%

Section: Raman Probes For Theranosticsmentioning

confidence: 99%

Section: Raman Probes For Theranosticsmentioning

confidence: 99%

Section: Raman Probes For Theranosticsmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

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