2016
DOI: 10.1016/j.vetimm.2016.01.005
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Multiplex cytokine analyses in dogs with pyometra suggest involvement of KC-like chemokine in canine bacterial sepsis

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Cited by 37 publications
(49 citation statements)
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“…The cytokine profile of dogs with sepsis in the present study was predominantly proinflammatory, with 4 cytokines (IL‐6, CXCL8, KC‐like, and CCL2) increased compared with healthy controls. These results are comparable to a study of dogs with pyometra that demonstrated greater concentrations of KC‐like in dogs with pyometra than healthy dogs . A subset of the cytokines measured (IL‐6, CXCL8, KC‐like) was also increased in dogs with nSIRS compared with controls.…”
Section: Discussionmentioning
confidence: 51%
“…The cytokine profile of dogs with sepsis in the present study was predominantly proinflammatory, with 4 cytokines (IL‐6, CXCL8, KC‐like, and CCL2) increased compared with healthy controls. These results are comparable to a study of dogs with pyometra that demonstrated greater concentrations of KC‐like in dogs with pyometra than healthy dogs . A subset of the cytokines measured (IL‐6, CXCL8, KC‐like) was also increased in dogs with nSIRS compared with controls.…”
Section: Discussionmentioning
confidence: 51%
“…Increased concentrations of KC-like cytokine, a neutrophil chemoattractant, have been found in dogs with pyometra and in experimental Lyme myocarditis models. 50, 51 The most commonly found inflammatory biomarkers in human ORCD and metabolic syndrome, CRP, TNF-alpha, and IL-6 were not significantly different between the groups of dogs. 52,53 This difference may represent a difference in the inflammatory profiles of obesity-related inflammation in dogs compared to people.…”
Section: Discussionmentioning
confidence: 90%
“…Limited information is available regarding the role of KC‐like cytokines, but they appear to play a role in systemic or generalized inflammation. Increased concentrations of KC‐like cytokine, a neutrophil chemoattractant, have been found in dogs with pyometra and in experimental Lyme myocarditis models . The most commonly found inflammatory biomarkers in human ORCD and metabolic syndrome, CRP, TNF‐alpha, and IL‐6 were not significantly different between the groups of dogs .…”
Section: Discussionmentioning
confidence: 91%
“…These defenses include passive factors, such as pH, mucus, and the epithelial barrier, and active factors, such as the inflammatory cascade and the secretion of humoral factors including mucin, acids, lysozymes, lactoferrin, peroxidase enzymes, antimicrobial proteins, and interferon-α (1011). Humoral immunity and cellular defense strategies may also be involved in rapid protection before antigenic stimulation (810).…”
Section: Discussionmentioning
confidence: 99%