Multiplex electrochemical aptasensors for detection of endothelial dysfunction: Ready for prime time?

Grabowska, I.; Zapotoczny, S.; Chlopicki, S.

doi:10.1016/j.trac.2023.117372

Cited by 9 publications

(4 citation statements)

References 67 publications

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“…The development of electrochemical aptasensors with the so-called label-free strategy is carried out by inserting the aptamer on the surface of the transducer and the recognition reaction is monitored through its interference in the electrochemical reaction between the modified surface and a redox probe [98].…”

Section: Discussionmentioning

confidence: 99%

“…These redox probes are chosen according to the profile, smallest difference between the oxidation and reduction peaks (reversibility), and constant behavior. The response potential range must be considered according to the electrode used [98]. Wang et al developed an electrochemical biosensor with an aptamer as a recognizer for determining sulfamethazine (SMZ).…”

Section: Configurations Of Electrochemical Aptasensorsmentioning

confidence: 99%

“…Thus, the electrochemical signals measured depending on the changes that occur on the surfaces of these biosensors have the possibility of being "signal-on" or "signal-off" (Figure 6), that is, there will be a greater or lesser intensity in the signal measured after the interaction of the biological material with the analyte, depending on the assay format used in the development of the aptasensor. In these strategies, aptasensors are called structure switching [97,98]. Wang et al developed an electrochemical biosensor with an aptamer as a recognizer for determining sulfamethazine (SMZ).…”

Section: Configurations Of Electrochemical Aptasensorsmentioning

confidence: 99%

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Relevant Aspects in the Development of Electrochemical Aptasensors for the Determination of Antibiotics—A Review

da Silva,

Pereira

2023

Electrochem

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Aptamers are three-dimensional structures of DNA or RNA that present high affinity and selectivity to specific targets, obtained through in vitro screening. Aptamers are used as biological recognizers in electrochemical biosensors, the so-called aptasensors, providing greater specificity in recognizing the most diverse analytes. Electrochemical aptasensors have extremely relevant characteristics, such as high sensitivity, low cost compared to other biorecognizers such as antibodies, and excellent compatibility, being considered one of the most promising alternative methods in several areas, such as biomedical diagnosis and monitoring environmental contaminants. In this sense, the present work reviews the relevant aspects of methodologies based on electrochemical aptasensors and their applications in determining antibiotics, seeking to foster innovation in electrochemical biosensors.

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Section: Discussionmentioning

confidence: 99%

Section: Configurations Of Electrochemical Aptasensorsmentioning

confidence: 99%

Section: Configurations Of Electrochemical Aptasensorsmentioning

confidence: 99%

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Relevant Aspects in the Development of Electrochemical Aptasensors for the Determination of Antibiotics—A Review

da Silva,

Pereira

2023

Electrochem

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“…Grabowska et al explained it due to the high specificity, stability in elevated temperatures, easier synthesis, and chemical modification when compared to antibodies. 91 Despite the great potential of aptamer-functionalized PB-biosensors, there are only a few studies exploring this area. In one of them, thrombin aptamers were attached to poly(N-(2-hydroxypropyl)methacrylamide)-copoly(carboxybetaine methacrylamide) (PHPMA-co-PCBMAA) brushes by EDC/NHS chemistry, leading to high aptamer surface coverage combined with antifouling properties.…”

Section: Biosensorsmentioning

confidence: 99%

Applications of surface‐grafted polymer brushes with various architectures

Kiełbasa,

Kowalczyk,

Chajec‐Gierczak

et al. 2024

Polymers for Advanced Techs

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Surface‐grafted polymer brushes (PBs) are a versatile class of thin coatings that exhibit unique properties due to their densely grafted polymer chains. PBs are typically formed through surface‐initiated polymerizations, particularly reversible deactivation radical polymerizations, and macromolecules adopt extended conformations that differentiate them from classical polymer films. This review explores various applications of PBs, emphasizing their macromolecular ordering, dynamic conformational changes, anisotropic properties, and so forth. The growing interest in utilizing PBs for functional coatings is discussed in various fields, including electronic, biological, and environmental applications. In electronic applications, PBs find relevance in photovoltaics, energy storage devices, organic light‐emitting diodes, and organic electronics, showcasing their potential in advancing electronic technologies. In biological applications, they contribute to the formation of antifouling and antibacterial coatings, as well as superior lubrication and cellular adhesion, making them valuable in biomedical settings. Other applications include biosensors, bioimaging systems, and drug delivery systems, highlighting their significant contributions to medical advancements. Additionally, PBs play an important role in environmental applications such as water and wastewater treatment. A variety of recent examples of the applications of surface‐grafted PBs are presented, providing insights into their unique properties and architectures that contribute to their success in demanding areas of science and technology.

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A dual-switch electrochemical aptasensor for label-free detection of thrombin and ATP based on split aptamers

Song,

Wu,

Fan

et al. 2025

Analytica Chimica Acta

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Multiplex electrochemical aptasensors for detection of endothelial dysfunction: Ready for prime time?

Cited by 9 publications

References 67 publications

Relevant Aspects in the Development of Electrochemical Aptasensors for the Determination of Antibiotics—A Review

Relevant Aspects in the Development of Electrochemical Aptasensors for the Determination of Antibiotics—A Review

Applications of surface‐grafted polymer brushes with various architectures

A dual-switch electrochemical aptasensor for label-free detection of thrombin and ATP based on split aptamers

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