Multiplexed surface plasmon imaging of serum biomolecules: Fe3O4@Au Core/shell nanoparticles with plasmonic simulation insights

Superparamagnetic nanoarchitectures for disease-specific biomarker detection

“…Both the number of analytes bound onto the sensor (i.e., antigen for an antibody or miRNA for a capture nucleotide) and the level of interaction of the detection probe-loaded core/shell NP labels stimulates the SPR signal change. 270 Interestingly, the changes are larger for small oligonucleotide hybridization than for the large sandwich protein immuno-mode. A more recent example of a magnet-assisted LSPR immunoassay in which Fe3O4/Au core-shell NPs (FACSNPs) were utilized to fabricate sensing spots of a microarray system.…”

“…268,269 The integration of MNPs with plasmonic NPs such as Au, Ag, or Pt facilitates the dual benefit of MNP-based easy and various modes of conjugation, dispersibility, and magnetic separation of preferred biomolecules, as well as plasmonic NPbased SPR signal amplification. [270][271][272] For instance, citrate-stabilized Fe3O4@Au core-shell…”

The future of microbiome analysis: Biosensor methods for big data collection and clinical diagnostics

“…A variety of biosensor methods have been used to detect multiple targets of interest simultaneously from relevant sample matrices. In the clinical realm, biosensors are used to detect biomarkers from samples such as faeces, serum or plasma (Battista et al., 2017; Broyles, Cissell, Kumar, & Deo, 2012; de Bruin et al., 2011; Hansbauer et al., 2017; Kraft, Lacher, Shelver, Sherwood, & Bergholz, 2017; Noll et al., 2016, 2018; Premaratne et al., 2019; Zhou, Bergeron, & Juncker, 2015). Biosensors are also used to detect offensive molecules in food products, such as contaminants or allergens (Asensi et al, 2009; Bai et al., 2013; Bluhm, Cousin, & Woloshuk, 2004; Bogožalec Košir, Demšar, Štebih, Žel, & Milavec, 2019; X. Chen et al., 2019; Croote, Braslavsky, & Quake, 2019; Hosking et al, 2019; Kim, Taitt, Ligler, & Anderson, 2010; Kloth, Niessner, & Seidel, 2009; Kull et al., 2010; Nakano, 2018; Orlov, Znoyko, Cherkasov, Nikitin, & Nikitin, 2016; Pauly et al., 2009; Quintela, de los Reyes, Lin, & Wu, 2019; Y. Wang, Ravindranath, & Irudayaraj, 2011).…”

“…Reprinted with permission from Premaratne et al. (2019), copyright 2019 Elsevier. (c) Nanofabrication of a microfluidic colorimetric immunoassay for the detection of a mycotoxin commonly found in food samples.…”

“…Premaratne et al. (2019) took advantage of SPR properties to detect biomolecules in serum using bimetallic iron‐gold NPs functionalized with antibody and DNA receptors. Various nanomaterials have also been used for pathogen detection in food matrices (Chen et al., 2019; Kim et al., 2010; Pauly et al., 2009; Wang et al., 2011).…”