Multipoint recognition of domoic acid from seawater by dummy template molecularly imprinted solid-phase extraction coupled with high-performance liquid chromatography

He, Xiaolong; Chen, Jianlei; Wang, Jiangtao; Tan, Liju

doi:10.1016/j.chroma.2017.04.023

Cited by 26 publications

(8 citation statements)

References 21 publications

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“…For example, a compound that has the same functional groups or atoms that can bind to monomers can be a dummy template because it will provide the same interactions and binding sites with the target molecule or analyte 37,47 . How to choose the dummy molecules can also be determined by a computational approach 35,45 …”

Section: Dummy Templatesmentioning

confidence: 99%

Dummy template molecularly imprinted polymers as potential sorbents in the separation and purification of active compounds in natural products

Ariani,

Zuhrotun,

Manesiotis

et al. 2023

Polymers for Advanced Techs

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Molecular imprinting technology is a promising technique for separating, purifying, and enriching target compounds with high selectivity and sensitivity. The molecularly imprinted polymer (MIP) technique has developed rapidly in the separation and purification of chemical compounds and secondary metabolites of natural products. However, there are real challenges to the isolation of target compounds in natural products such as the unavailability of target compounds and high cost, so it is necessary to develop another approach to MIP synthesis. The dummy template is a solution to the unavailability of target compounds as it will produce a binding site that is specific enough for the target compound through covalent or non‐covalent bonds and the presence of the same functional groups between the target compound and the dummy will result in an interaction between the target compound and the binding site made using the dummy template. In addition, this dummy MIP (DMIP) is the best solution for overcoming the template leakage in traditional MIPs so that the DMIP technique is very good for removing and purifying compounds that are allergenic or toxic in natural product samples (high traceability). This review article will discuss the development of DMIPs in the separation and purification of compounds in natural products and the factors that affect their performance. Our discussion highlights the importance of selecting the right dummy template for optimal DMIP performance. This selection should be based on factors such as functional group similarity, being in the same bioactive compound group, and structural skeleton similarity. In addition, the selection and composition of other DMIP components can also affect the analytical performance of the DMIP.

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Section: Dummy Templatesmentioning

confidence: 99%

Dummy template molecularly imprinted polymers as potential sorbents in the separation and purification of active compounds in natural products

Ariani,

Zuhrotun,

Manesiotis

et al. 2023

Polymers for Advanced Techs

View full text Add to dashboard Cite

show abstract

“…At present, the main methods for the analysis of DA included high-performance liquid chromatography-ultraviolet detector (HPLC-UV) [ 6 , 7 , 8 , 9 , 10 , 11 , 12 ], liquid chromatography-tandem mass spectrometry (LC-MS/MS) [ 13 , 14 , 15 , 16 , 17 ], Capillary electrochromatography (CE) [ 18 , 19 , 20 ], Animal experiment [ 21 , 22 ], Enzyme-linked immunoassay (ELISA) [ 23 , 24 ] assay and so on. However, the low concentrations of DA and high matrix complexities made it more difficult for precise quantitative analysis in complex samples.…”

Section: Introductionmentioning

confidence: 99%

Application of a reversed-phase ionic liquid dispersive liquid-liquid microextraction method for the extraction and preconcentration of domoic acid from urine samples

Wang

Liang

Sun

et al. 2022

Heliyon

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“…In recent years, MIPs have been widely used in liquid chromatographic separation and solid‐phase extraction (SPE) to separate and purify natural compounds. MIPs are promising SPE sorbents that can pre‐enrich analytical samples from real complex samples, thereby allowing the development of fast, sensitive and inexpensive analytical methods 23–25 . Many research results have confirmed that MIP particles are superior to commercially available materials such as C18 and MCX Oasis as SPE sorbents 25–27 …”

Section: Introductionmentioning

confidence: 99%

Preparation of ordered macroporous molecularly imprinted polymers and their applications in purifying cinchona alkaloids from cinchona extract

Zhang

Rui

Lin

et al. 2021

Polymer International

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Three‐dimensionally ordered macroporous molecularly imprinted polymers (3DOM MIPs) were prepared for the direct purification of cinchona alkaloids from crude cinchona extract. The 3DOM MIPs were easily prepared by grafting quinine‐MIPs on the pore walls of 3DOM thiol‐group‐functionalized silica. The materials were characterized using various techniques. The results showed that the 3DOM MIPs had a more regular macroporous structure, a greater surface area and a greater porosity than traditional bulk MIPs (TBMIPs). The 3DOM MIPs could reach a high MIP content of 69.9%. And the 3DOM structure could improve intraparticle adsorption and provide more accessible adsorption sites. Consequently, in both static adsorption experiments and solid‐phase extraction (SPE), the actual adsorption capacity of the imprinted polymers of the 3DOM MIPs was about 83% higher than that of TBMIPs. Moreover, the 3DOM MIPs exhibited high affinity for quinine, quinidine and cinchonine. Using the quinine‐3DOM MIPs as SPE sorbent, quinine, quinidine and cinchonine could be effectively purified from crude cinchona extract with high elution recoveries. Control experiments also showed that the 3DOM MIPs were superior to commercially available adsorbents in terms of the purification of cinchona alkaloids from crude extract. © 2021 Society of Chemical Industry

show abstract

Multipoint recognition of domoic acid from seawater by dummy template molecularly imprinted solid-phase extraction coupled with high-performance liquid chromatography

Cited by 26 publications

References 21 publications

Dummy template molecularly imprinted polymers as potential sorbents in the separation and purification of active compounds in natural products

Dummy template molecularly imprinted polymers as potential sorbents in the separation and purification of active compounds in natural products

Application of a reversed-phase ionic liquid dispersive liquid-liquid microextraction method for the extraction and preconcentration of domoic acid from urine samples

Preparation of ordered macroporous molecularly imprinted polymers and their applications in purifying cinchona alkaloids from cinchona extract

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