Multipotent stem cells from apical pulp of human deciduous teeth with immature apex

Xiong, Huacui; Chen, Ke

doi:10.1016/j.tice.2021.101556

Cited by 5 publications

(1 citation statement)

References 37 publications

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“…These data support the suggestion that SCAP are a unique postnatal stem cell population [ 53 ]. These cells can be isolated and cultured efficiently through enzymatic digestion (collagenase type I) or by explant culture, in which case papillary tissue is cut into 1 mm 3 samples and seeded on culture plates [ 177 ]. Until now, SCAP showed the expression characteristics of MSC markers: self-renovation, proliferation, migration, differentiation, and immunosuppression, allowing SCAP to participate in regenerative medicine, even immunotherapy, and dental, bony, cartilaginous, neural, hepatic, and vascular tissue regeneration [ 178 ].…”

Section: Types Of Mesenchymal Stem Cells From the Oral Cavity (Dmsc I...mentioning

confidence: 99%

Adult Mesenchymal Stem Cells from Oral Cavity and Surrounding Areas: Types and Biomedical Applications

Cabaña-Muñoz,

Pelaz Fernández,

Parmigiani-Cabaña

et al. 2023

Pharmaceutics

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Adult mesenchymal stem cells are those obtained from the conformation of dental structures (DMSC), such as deciduous and permanent teeth and other surrounding tissues. Background: The self-renewal and differentiation capacities of these adult stem cells allow for great clinical potential. Because DMSC are cells of ectomesenchymal origin, they reveal a high capacity for complete regeneration of dental pulp, periodontal tissue, and other biomedical applications; their differentiation into other types of cells promotes repair in muscle tissue, cardiac, pancreatic, nervous, bone, cartilage, skin, and corneal tissues, among others, with a high predictability of success. Therefore, stem and progenitor cells, with their exosomes of dental origin and surrounding areas in the oral cavity due to their plasticity, are considered a fundamental pillar in medicine and regenerative dentistry. Tissue engineering (MSCs, scaffolds, and bioactive molecules) sustains and induces its multipotent and immunomodulatory effects. It is of vital importance to guarantee the safety and efficacy of the procedures designed for patients, and for this purpose, more clinical trials are needed to increase the efficacy of several pathologies. Conclusion: From a bioethical and transcendental anthropological point of view, the human person as a unique being facilitates better clinical and personalized therapy, given the higher prevalence of dental and chronic systemic diseases.

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Section: Types Of Mesenchymal Stem Cells From the Oral Cavity (Dmsc I...mentioning

confidence: 99%

Adult Mesenchymal Stem Cells from Oral Cavity and Surrounding Areas: Types and Biomedical Applications

Cabaña-Muñoz,

Pelaz Fernández,

Parmigiani-Cabaña

et al. 2023

Pharmaceutics

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Clinical study of iRoot-BP combined with collagen sponge in treatment of periapical inflammation

Qin,

Cai

2024

mat express

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The purpose of this research was to observe the clinical effect of iRoot-BP combined with collagen sponge for the treatment of periapical inflammation with lesions larger than 10 mm and undeveloped apical foramen. 26 teeth from 25 patients with periapical inflammation meeting the inclusion criteria were randomly assigned into two groups with 13 teeth per group. In collagen sponge group, the apical barrier was performed using iRoot-BP combined with collagen sponge, and in non-collagen sponge group was only treated with iRoot-BP. Patients in two groups were followed up at 3, 6 and 12 months respectively, and the therapeutic effect was judged according to the clinical and imaging findings. The prognosis of periapical lesions indicated that there were 13 of treated teeth in collagen sponge group and 11 of treated teeth in non-collagen sponge group show no signs of clinical or radiographic failure (χ2 = 2.167, p = 0.14). The observation results of continued root growth suggested that the average root growth of collagen group was 2 mm, while no continuous root growth was observed in non-collagen sponge group (p < 0.05). Application of iRoot-BP combined with collagen sponge has obvious advantages in treatment of large-scale periapical inflammation with undeveloped apical foramen, which can promote the formation of immature roots closer to the normal roots.

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Clinical study of collagen sponge combined with iRoot in apical barriers

Qin

Gong

2022

Preprint

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Background/Aim Placement of biocompatible material to obtain a good apical stop is one of the important factors that determine the success of apical barriers. The purpose of this study was to observe the clinical and radiographic outcomes of the apical plug performed using iRoot-BP, with or without collagen sponge in immature teeth with necrotic pulp, so as to provide theoretical basis for clinical application. Materials and Methods Forty-six immature teeth with necrotic pulps were included in this study. Teeth were equally divided and randomly assigned to two groups: sponge group (group KD) or control group (group NC). During apical barriers, apical plug performed with iRoot-BP or sponge + iRoot-BP followed by a permanent restoration. Blinded clinical and radiographic assessments were performed at baseline, immediate post-operative and after 3, 6 and 12 months, according to the pre-determined clinical and radiographic criteria. Results ①The evaluation results of apical lesion healing showed that 22 treated teeth in group KD (95.7%) and 21 treated teeth in group NC (91.3%) showed no clinical or radiographic signs of failure during the follow-up period (χ2 = 0.357, P = 0.55). ②The results of continuous root growth assessment showed that the root of affected teeth in group KD increased by 2 mm on average. There was statistically significant difference between group KD and group NC(P < 0.05). Conclusion Whether collagen sponge is added, iRoot-BP showed similar clinical and radiographic outcomes when used as apical barriers materials in the treatment of immature permanent teeth with necrotic pulps. However, the application of collagen sponge combined with iRoot-BP in apical barriers can promote root development of immature teeth, which is closer to the formation of normal root.

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Multipotent stem cells from apical pulp of human deciduous teeth with immature apex

Cited by 5 publications

References 37 publications

Adult Mesenchymal Stem Cells from Oral Cavity and Surrounding Areas: Types and Biomedical Applications

Adult Mesenchymal Stem Cells from Oral Cavity and Surrounding Areas: Types and Biomedical Applications

Clinical study of iRoot-BP combined with collagen sponge in treatment of periapical inflammation

Clinical study of collagen sponge combined with iRoot in apical barriers

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