Multispecies and multiple anthelmintic resistance on cattle nematodes in a farm in
Argentina: the beginning of high resistance?

Mejía, Miguel E.; Igartúa, Belisario M. Fernández; Schmidt, Enrique Eberardo; Cabaret, Jacques

doi:10.1051/vetres:2003018

Cited by 98 publications

(61 citation statements)

References 14 publications

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“…The formula used was: FECR = 100 *[1-(T2/T1)], being T2 the EPG average on PT day 22 and T1 the EPG average on pretreatment day 0 (Mejia et al 2003, Cristel & Suarez 2006.…”

Section: Data Calculations and Statistical Analysismentioning

confidence: 99%

“…Most of the times, IVM has been adopted as the only tool for anthelmintic control, without considering other epidemiologic variables (Sievers & Alocilla 2007, Canul-Ku et al 2011. In Argentina, the ϐirst references to anthelmintic resistance to IVM in cattle were made by Fiel et al (2000Fiel et al ( , 2001 and Anziani et al (2001), and afterwards, cases of anthelmintic resistance to different chemical groups of drugs have been frequently described (Mejia et al 2003, Anziani et al 2004, Caracostantogolo et al 2005.…”

Section: Introductionmentioning

confidence: 99%

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Impact of ivermectin-resistant gastrointestinal nematodes in feedlot cattle in Argentina

et al. 2012

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The aim was to evaluate for 75 days the impact on production of the remaining burden of ivermectin (IVM)-resistant parasites in naturally infected feedlot calves. The herds came from tick-infested areas of cattle breeding where the systematic use of IVM to control tick increases the gastrointestinal parasites resistant to this drug. This investigation was carried out in two commercial feedlots in Buenos Aires province. In feedlot A, two groups of 35 animal each received IVM 1% and the other received ricobendazole (RBZ) 10% respectively. The same was done in feedlot B. On day 0, two groups of 35 animals were made in feedlots A and B. Fecal samples were taken on days 0, 22, 54 and 75 pos-treatment (PT), and body weight was registered, from each animal. Fecal samples were processed for individual count of eggs per gram (EPG) and pooled fecal culture was carried out for identiϐication of the parasite genus in each sampling. Fecal egg count reduction test (FECR) was calculated on day 22 PT. The study design used was a totally randomized block, with commercial feedlot and sex as block variables. For data analysis, a mixed model of the SAS statistical program was used. The FECR average on day 22 was 28.4% in the IVM group, and 94,2 % in the RBZ group . From this date on, signiϐicant differences in EPG were kept until day 54. EPG counts were only equal near the end of the trial, on day 75 (p=0.16). In both commercial feedlots, especially in the IVM group, Cooperia spp. was the most prevalent parasite in the fecal cultures. Signiϐicant differences in weight (P<0.01) on post-treatment day 75 was found between the average weight in the RBZ and the IVM group (246 vs. 238 kg respectively), what means a difference of 8.3% in gains. The importance for production in the antiparasite failure treatment in commercial feedlots was demonstrated, and the need of pos-treatment controls to evaluate the efϐicacy of the antiparasitic administered is emphasized.

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“…The formula used was: FECR = 100 *[1-(T2/T1)], being T2 the EPG average on PT day 22 and T1 the EPG average on pretreatment day 0 (Mejia et al 2003, Cristel & Suarez 2006.…”

Section: Data Calculations and Statistical Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Impact of ivermectin-resistant gastrointestinal nematodes in feedlot cattle in Argentina

et al. 2012

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“…In Argentina, the first cases of macrocyclic lactone and benzimidazoles resistance in cattle were reported by Anziani et al (2001) and Fiel et al (2001). Cases of multiple anthelmintic and nematode species resistance were detected later (MEJÍA et al, 2003;ANZIANI et al, 2004). Some recent surveys made in Argentina have attempted to quantify regional AR occurrence in cattle ranches (CARACOSTANTOGOLO et al, 2005;CRISTEL, 2007).…”

Section: Introductionmentioning

confidence: 99%

Risk factors for anthelmintic resistance development in cattle gastrointestinal nematodes in Argentina

Suárez

Cristel²

2014

Rev. Bras. Parasitol. Vet.

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Risk factors for anthelmintic resistance (AR) on bovine ranches were studied. Data were derived from a survey made to 50 ranch owners, who had conducted a faecal egg-count-reduction test. The questionnaire contained descriptors of bovine ranch management and nematode control. A case-control design study was undertaken and AR cases were present in 26 herds. Associations between the binary outcome variable (AR versus not AR) and risk factors recorded in the questionnaire were evaluated. Variables associated with the presence of AR at P< 0.15 and/or odds ratio (OR) > 2 were subjected to a multivariable logistic regression model. The main effects contributing to general AR (avermectin AVM and/or benzimidazole) in the final model were total number of annual treatments (OR 7.68; 95% CI 2.4 to 28.3) and use of more than 75% of AVM in the past (OR= 18.6; 95% CI 1.3 to 97.3), whereas for AVM resistance alone were total number of AVM annual treatments (OR= 11.5; 95% CI 2.9 to 45.5) and number of AVM Nov-Jan treatments (OR= 5.8; 95% CI 1.71 to 47.9). The results showed that treatment frequency, date of treatment and frequency of treatment in the past with a single drug were the main risk factors involved in AR development.Keywords: Nematode, cattle, anthelmintic resistance, risk factor. ResumoFatores de risco para resistência anti-helmíntica (AR) em fazendas de criação de bovinos foram estudados de dados obtidos de um levantamento em 50 propriedades. Em todas foram conduzidos testes de redução de contagem de ovos (opg) e um questionário preenchido pelos proprietários sobre o manejo e o controle de verminose nessas fazendas. Um estudo com desenho de caso controlado foi realizado e casos de AR estavam presentes em 26 rebanhos. Associações foram avaliadas entre a variável binária produzida (AR versus sem AR) e fatores de risco registrados nos questionários. Variáveis associadas com o resultado de interesse a P<0.15 e/ou razão de prevalência (OR) > 2 foram usados num modelo de regressão logística multivariável. Os principais efeitos contribuintes para AR geral (avermectina AVM e/ou benzimidazole), no modelo final, foram número total de tratamentos anuais (OR 7,68; 95% IC 2,4 a 28,3) e uso no passado mais que 75% de AVM (OR= 18,6; 95% IC 1,3 a 97,3), e para resistência à AVM foram número total de tratamentos anuais (OR=11,5; 95% IC 2,9 a 45,5), número de tratamentos com AVM de novembro a janeiro (OR= 5,8; 95% IC 1,71 a 47,9). Estes resultados mostraram que a frequência dos tratamentos, a época do ano em que foram feitos os tratamentos e a frequência dos tratamentos no passado com uma única droga foram os principais fatores de risco implicado no desenvolvimento de AR.Palavras-chave: Nematóide, gado, resistência anti-helmíntica, fator de risco.

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“…O uso indiscriminado acarretou queda da eficácia pela seleção de parasitas resistentes (LEATHWICK et al, 2001;MOLENTO, 2004), havendo, em alguns casos, resistência múltipla (MEJÍA et al, 2003) causada por tratamento supressivo com diferentes bases sobre uma população de parasitas.…”

Section: Ciência Rural V38 N7 Out 2008unclassified

“…No entanto, também já foi amplamente descrita em bovinos (COLES, 2002;MEJÍA et al, 2003;MELLO et al, 2006). O diagnóstico do grau de infecção animal e da contaminação ambiental por meio de exames clínicos e laboratoriais (EYSKER & PLOEGER, 2000) e o conhecimento da epidemiologia das nematodíases com suas particularidades regionais são indispensáveis na formulação de um programa de controle eficiente (BIANCHIN et al, 1993;WALLER, 1999), devendo-se, ainda, comprovar a eficácia dos anti-helmínticos eleitos para o uso no rebanho.…”

Section: Ciência Rural V38 N7 Out 2008unclassified

Controle alternativo de nematódeos gastrintestinais dos ruminantes: atualidade e perspectivas

2008

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Multispecies and multiple anthelmintic resistance on cattle nematodes in a farm in Argentina: the beginning of high resistance?

Abstract: -There are very few resistance records on cattle nematodes.

Cited by 98 publications

References 14 publications

Impact of ivermectin-resistant gastrointestinal nematodes in feedlot cattle in Argentina

Impact of ivermectin-resistant gastrointestinal nematodes in feedlot cattle in Argentina

Risk factors for anthelmintic resistance development in cattle gastrointestinal nematodes in Argentina

Controle alternativo de nematódeos gastrintestinais dos ruminantes: atualidade e perspectivas

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