2024
DOI: 10.1126/scitranslmed.ade7347
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Multispecies transcriptomics identifies SIKE as a MAPK repressor that prevents NASH progression

Lan Bai,
Weiyi Qu,
Xu Cheng
et al.

Abstract: Nonalcoholic fatty liver (NAFL) remains relatively benign, but high-risk to end-stage liver diseases become highly prevalent when it progresses into nonalcoholic steatohepatitis (NASH). Our current understanding of the development of NAFL to NASH remains insufficient. In this study, we revealed MAP kinase (MAPK) activation as the most notable molecular signature associated with NASH progression across multiple species. Furthermore, we identified suppressor of IKKε ( SIKE ) as a conserve… Show more

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