Multispectral near infrared absorption imaging for histology of skin cancer

Spreinat, Alexander; Selvaggio, Gabriele; Erpenbeck, Luise; Kruss, Sebastian

doi:10.1002/jbio.201960080

Cited by 26 publications

(15 citation statements)

References 35 publications

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“…More in detail, confocal Raman spectroscopy performs the analysis of the light that is scattered by the tissue; this, however, requires very costly instrumentation [13]. Similarly, methods such as near-IR [14] or Terahertz spectroscopy [15] involve expensive equipment. Other technologies are based on thermography which analyze the temperature of the skin or lesion surface from the intensity of emitted infrared radiation [16].…”

Section: Review Of the State Of The Art And Motivation Of The Present...mentioning

confidence: 99%

Microwave Reflectometry Sensing System For Low-Cost In-Vivo Skin Cancer Diagnostics

Schiavoni

Maietta

Filieri

et al. 2022

Preprint

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Skin cancer is one of the most commonly diffused cancer in the world and its incidence rates have constantly increased in recent years. At the current state of the art, there is a lack of objective, quick and non-invasive methods for diagnosing this condition; this, combined with hospital crowding, may lead to late diagnosis. Starting from these considerations, this paper addresses the implementation of a microwave reflectometry based-system that can be used as a non-invasive method for the in-vivo diagnosis and early detection of biological abnormalities, such as skin cancer. This system relies on the dielectric contrasts existing between normal and anomalous skin tissues at microwave frequencies. In particular, a truncated open-ended coaxial probe was designed, manufactured and tested to sense (in combination with a miniaturized Vector Network Analyzer) the variations of skin dielectric properties on a group of volunteer patients. The specific data processing demonstrated the suitability of the system for discriminating malignant and benign lesions from healthy skin, ensuring simultaneously effectiveness, low cost, compactness, comfortability and high sensitivity.

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Section: Review Of the State Of The Art And Motivation Of The Present...mentioning

confidence: 99%

Microwave Reflectometry Sensing System For Low-Cost In-Vivo Skin Cancer Diagnostics

Schiavoni

Maietta

Filieri

et al. 2022

Preprint

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“…Both are however emitting in the socalled NIR-I region (700 nm < λ < 900 nm), which, compared to regions of higher wavelengths (i.e. λ > 900 nm and the so-called NIR-II region with 1000 nm < λ < 1700 nm), present lower contrast and penetration depth in tissue 1,7 . For this reason, NIR-II emitters such as lanthanide-based nanocrystals, quantum dots (QDs), rare-earth-doped nanoparticles (RENPs), singlewalled carbon nanotubes (SWCNTs) and some organic dyes have received a lot of attention in recent years 1,5,6 .…”

Section: Introductionmentioning

confidence: 99%

NIR-emitting benzene-fused oligo-BODIPYs for bioimaging

Selvaggio¹,

Nißler²,

Nietmann³

et al. 2022

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“…Especially as novel NIR fluorophore, EB-NS appears of extreme interest. Fluorophores that emit in the NIR window (NIR-I: λ ≈ 750-1000 nm; NIR-II: λ ≈ 1000-1700 nm) present optimal characteristics for bioimaging due to reduced phototoxicity, scattering, absorption and autofluorescence of biological samples at these wavelengths [38][39][40][41] . Although organic dyes (e.g.…”

Section: Introductionmentioning

confidence: 99%

Covalently Functionalized Egyptian Blue Nanosheets for Near-Infrared Bioimaging

Selvaggio

Herrmann

Hill

et al. 2022

Preprint

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Fluorophores emitting in the near-infrared (NIR) wavelength region present optimal characteristics for photonics and especially bioimaging. Unfortunately, only few NIR fluorescent materials are known and even fewer are biocompatible. For this reason, the scientific interest in designing novel NIR fluorophores is very high. Egyptian Blue (CaCuSi4O10, EB) is a NIR fluorescent layered silicate that can be exfoliated into fluorescent nanosheets (EB-NS). So far, its surface chemistry has not been tailored but this is crucial for colloidal stability and biological targeting. Here, we demonstrate covalent surface functionalization of EB nanosheets (EBfunc) via Si-H activation using hydrosilanes with variable functionalities. EB-NS were first grafted with the visible fluorescent pyrene (Pyr) moieties to prove conjugation by colocalization of the Vis/NIR fluorescence on the (single) EB-NS level. The same procedure was performed and validated with carboxyl group (COOH)-containing hydrosilanes. These groups can serve as generic handle for further (bio)functionalization of the EB-NS surface. Finally, folic acid (FA) was conjugated to these COOH-functionalized EB-NS to target folic acid receptor-expressing cancer cells. These results highlight the potential of this surface chemistry approach to modify EB-NS and enable targeted NIR imaging for biomedical applications.

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Multispectral near infrared absorption imaging for histology of skin cancer

Cited by 26 publications

References 35 publications

Microwave Reflectometry Sensing System For Low-Cost In-Vivo Skin Cancer Diagnostics

Microwave Reflectometry Sensing System For Low-Cost In-Vivo Skin Cancer Diagnostics

NIR-emitting benzene-fused oligo-BODIPYs for bioimaging

Covalently Functionalized Egyptian Blue Nanosheets for Near-Infrared Bioimaging

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