Multispectral studies of DNA binding, antioxidant and cytotoxic activities of a new pyranochromene derivative

Spectroscopic studies, structural characterization and electrochemical studies of two cobalt (III) complexes with tridentate hydrazone Schiff base ligands: Evaluation of antibacterial activities, DNA‐binding, BSA interaction and molecular docking

“…Incubating DNA with drug results in a conformational change in the DNA, as the conversion from a more B‐like to a more C‐like state. The incubation of DNA with drug shows less perturbations at the bands, attributed to a typical non‐intercalative mode for all synthesized compounds, as shown in Figure …”

“…On the other hand, hyperchromism can be attributed to external contact (surface binding) with the duplex . Furthermore, the observed hyperchromism and no shift in the location of the peak (258 nm) is indicative of partial or non‐intercalative‐binding modes (Figure ), such as dative bonds, electrostatic forces, hydrogen bonds, van der Waals forces and hydrophobic interactions . These hyperchromic shifts indicate that all the synthesized compounds interact with CT‐DNA with non‐intercalative‐binding modes.…”

“…Thus, these results imply that the synthesized compounds interact with DNA via non‐intercalating, and interaction between MB and DNA is intercalating as the interaction between synthesized compounds with DNA‐MB does not cause a significant change in the emission, and this is evidence for non‐intercalative mode of binding. In other words, MB molecules are not released from the DNA helix after the addition of H 2 L 1 , H 2 L 2 , 1 and 2 …”

Synthesis and Anticancer Activities of Novel Pyranocoumarin Fused Pyrimidine Based on Cyanoenamine

“…具有烯胺腈结构的 4-取代吡喃香豆素本身也具有 一定的生物活性, 如抗肿瘤及抗氧化 [18] 、抗菌 [19] 、抗嘌 呤氧化抑制剂 [20] 、乙酰胆碱酯酶抑制剂 [21] 等(图 4). 肿瘤活性 [22] , 阳性对照物为抗肿瘤药物多西紫杉醇 实验所用人宫颈癌细胞株 Hela 由第四军医大学提 供, 人急性早幼粒白血病细胞株 HL-60 由香港理工大学 Chan Kin-Fai 博士提供.…”

Copper Schiff base functionalized polyaniline (Cu‐SB/PANI): A highly efficient polymer based organometallic catalyst for the synthesis of 2‐amino chromene derivatives

“…Among the known derivatives, 2‐amino chromene derivatives have received extensive consideration owing to their biological and medicinal significance. They have been found to show a wide spectrum of biological activities such as antibacterial, anti‐oxidant, acetylcholinesterase (AChE) inhibitory, antituberculosis, antimicrobial, anti‐anaphylactic, antifungal, anti‐rheumatic, antiproliferative, antitumor etc.…”