Multispectroscopic and synergistic antioxidant study on the combined binding of caffeic acid and (-)-epicatechin gallate to lysozyme

Li, He; Wang, Danfeng; Ren, Yongfang; Wang, Lu; Weng, Tianxin; Liu, Jie; Wu, Yushu; Ding, Zhuang; Liu, Min

doi:10.1016/j.saa.2022.120986

Cited by 22 publications

(10 citation statements)

References 64 publications

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“…For example, the presence of chlorogenic acid strongly hinders the binding of EGCG to lysozyme, resulting from the same binding site of two polyphenols to the protein (Liu, Liu, Wang, et al., 2021). Similar results were also observed in the simultaneous binding of caffeic acid and (–)‐epicatechin gallate to lysozyme (Liu, Wang, et al., 2022). Notably, the competitive binding phenomenon was commonly observed in the simultaneous binding of multiple ligands to globular proteins, such as trans ‐resveratrol and cis ‐resveratrol to β‐LG/BSA/α‐LA (Cheng, Fang, Wusigale, et al., 2018).…”

Section: Protein–multiligand Nanocomplexessupporting

confidence: 79%

A comprehensive review of protein‐based carriers with simple structures for the co‐encapsulation of bioactive agents

Cheng

Chen

Jiang

et al. 2023

Comp Rev Food Sci Food Safe

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The rational design and fabrication of edible codelivery carriers are important to develop functional foods fortified with a plurality of bioactive agents, which may produce synergistic effects in increasing bioactivity and functionality to target specific health benefits. Food proteins possess considerable functional attributes that make them suitable for the delivery of a single bioactive agent in a wide range of platforms. Among the different types of protein‐based carriers, protein–ligand nanocomplexes, micro/nanoparticles, and oil‐in‐water (O/W) emulsions have increasingly attracted attention in the codelivery of multiple bioactive agents, due to the simple and convenient preparation procedure, high stability, matrix compatibility, and dosage flexibility. However, the successful codelivery of bioactive agents with diverse physicochemical properties by using these simple‐structure carriers is a daunting task. In this review, some effective strategies such as combined functional properties of proteins, self‐assembly, composite, layer‐by‐layer, and interfacial engineering are introduced to redesign the carrier structure and explore the encapsulation of multiple bioactive agents. It then highlights success stories and challenges in the co‐encapsulation of multiple bioactive agents within protein‐based carriers with a simple structure. The partition, protection, and release of bioactive agents in these protein‐based codelivery carriers are considered and discussed. Finally, safety and application as well as challenges of co‐encapsulated bioactive agents in the food industry are also discussed. This work provides a state‐of‐the‐art overview of protein‐based particles and O/W emulsions in co‐encapsulating bioactive agents, which is essential for the design and development of novel functional foods containing multiple bioactive agents.

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Section: Protein–multiligand Nanocomplexessupporting

confidence: 79%

A comprehensive review of protein‐based carriers with simple structures for the co‐encapsulation of bioactive agents

Cheng

Chen

Jiang

et al. 2023

Comp Rev Food Sci Food Safe

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“…Pickering emulsion stabilized by CNC can achieve increased loading and sustained release of DHM and can improve the stability of DHM (P Shen et al., 2022 ). Lysozyme (LY) is a multifunctional natural single-chain protein, which not only acts as an antibacterial agent but also has many beneficial effects such as regulating intestinal flora and reducing inflammation (H Liu, Wang, et al., 2022 ). In the research of Geng et al., DHM was adsorbed on the surface of LY to form a three-dimensional network structure to stabilize Pickering high internal phase emulsion (HIPE).…”

Section: Pharmaceutical Designs Of Dhmmentioning

confidence: 99%

“…They can form DHM-PTX cocrystal hydrate by hydrogen bonding. After forming cocrystal, DHM and PTX can be released synchronously and have a synergistic anti-cancer effect on HepG2 cells in vitro (L Liu et al., 2022 ). Similarly, Li et al.…”

Section: Pharmaceutical Designs Of Dhmmentioning

confidence: 99%

“…At 25 °C and 37 °C, the solubility of DHM in water is about 0.2 mg/ml and 0.9 mg/ml, respectively (L Fan et al., 2017 ). To increase its solubility, permeability, and stability, researchers have developed many new dosage forms for DHM, such as nano-preparations, microemulsions, gels, crystals, phospholipid complexes, and cyclodextrin complexes, etc., thereby improving the medicinal properties of DHM (CC Sun et al., 2020 ; S Geng, Jiang, et al., 2021 ; L Liu et al., 2022 ). It has been reported that DHM can distribute in various tissues and can pass through the blood-brain barrier after oral administration in rats, which provides further conditions for curing various diseases (L Fan et al., 2017 ).…”

Section: Introductionmentioning

confidence: 99%

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Strategic developments in the drug delivery of natural product dihydromyricetin: applications, prospects, and challenges

et al. 2022

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Dihydromyricetin (DHM) is an important natural flavonoid that has attracted much attention because of its various functions such as protecting the cardiovascular system and liver, treating cancer and neurodegenerative diseases, and anti-inflammation effect, etc. Despite its great development potential in pharmacy, DHM has some problems in pharmaceutical applications such as low solubility, permeability, and stability. To settle these issues, extensive research has been carried out on its physicochemical properties and dosage forms to produce all kinds of DHM preparations in the past ten years. In addition, the combined use of DHM with other drugs is a promising strategy to expand the application of DHM. However, although invention patents for DHM preparations have been issued in several countries, the current transformation of DHM research results into market products is insufficient. To date, there is still a lack of deep research into the pharmacokinetics, pharmacodynamics, toxicology, and action mechanism of DHM preparations. Besides, preparations for combined therapy of DHM with other drugs are scarcely reported, which necessitates the development of dosage forms for this application. Apart from medicine, the development of DHM in the food industry is also of great potential. Due to its multiple effects and excellent safety, DHM preparations can be developed for functional drinks and foods. Through this review, we hope to draw more attention to the development potential of DHM and the above challenges and provide valuable references for the research and development of other natural products with a similar structure-activity relationship to this drug.

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“…14,15 Caffeic acid is a natural phenolic compound widely found in vegetables, fruits, coffee, tea, wine and other plant derived substances, which has a variety of biological functions, such as antioxidant, antimutagenic, antidepressant, anti-anxiety, and anti-cancer activities. 16 Moreover, recent studies have shown that caffeic acid can interact with many proteins and influence their properties, including lysozyme 17 and myofibrillar proteins, 18 so attaching ferritin with caffeic acid may be feasible to be realized. The nanosized diameter, two partitioned interfaces, and reversible assembly character of the ferritin may provide ideal foundations to bind, deliver, and stabilize bioactive molecules such as betanin.…”

Section: Introductionmentioning

confidence: 99%

Phytoferritin functions in two interface-loading of natural pigment betanin and caffeic acid with enhanced color stability and the sustained release of betanin

Zhang¹,

Sha²,

Hu³

et al. 2023

Food Funct.

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Multispectroscopic and synergistic antioxidant study on the combined binding of caffeic acid and (-)-epicatechin gallate to lysozyme

Cited by 22 publications

References 64 publications

A comprehensive review of protein‐based carriers with simple structures for the co‐encapsulation of bioactive agents

A comprehensive review of protein‐based carriers with simple structures for the co‐encapsulation of bioactive agents

Strategic developments in the drug delivery of natural product dihydromyricetin: applications, prospects, and challenges

Phytoferritin functions in two interface-loading of natural pigment betanin and caffeic acid with enhanced color stability and the sustained release of betanin

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