Multitensor Tractography Enables Better Depiction of Motor Pathways: Initial Clinical Experience Using Diffusion-Weighted MR Imaging with Standard b-Value

Yamada, Kazuo; Sakai, Koji; Hoogenraad, F.; Holthuizen, Ronald; Akazawa, Kentaro; Ito, Hirotoshi; Oouchi, H.; Matsushima, Shigenori; Kubota, Takao; Sasajima, Hiroyasu; Mineura, Katsuyoshi; Nishimura, Tsunehiko

doi:10.3174/ajnr.a0640

Cited by 33 publications

(28 citation statements)

References 20 publications

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“…According to their study, the motor homunculus should have an anteroposterior alignment along the long axis of the PLIC. The results of our study are in a good agreement with the results of Yamada et al, 26 indicating that the hand pathways are located anterior to the foot pathways in the PLIC. Furthermore, our results demonstrate that the CBT (tongue and face fibers) is oriented anterior to the CST in the internal capsule.…”

Section: Discussionsupporting

confidence: 93%

Somatotopic Organization of Motor Pathways in the Internal Capsule: A Probabilistic Diffusion Tractography Study

Pan

Peck

Young³

et al. 2012

AJNR Am J Neuroradiol

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Section: Discussionsupporting

confidence: 93%

Somatotopic Organization of Motor Pathways in the Internal Capsule: A Probabilistic Diffusion Tractography Study

Pan

Peck

Young³

et al. 2012

AJNR Am J Neuroradiol

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“…5 Based on the method of Yamada and associates, 11 we performed tracking only when the following 3 criteria were met: the signal intensity on the b＝0 image exceeded 200; the FA value exceeded 0.1 to 0.3; and the angle by which the tract changed from one voxel to the next did not exceed 279 .…”

Section: Fiber-tracking Methodsmentioning

confidence: 99%

“…11 In single-tensor tractography, 32 apparent diŠusion coe‹cients (ADCs) calculated for each voxel were used toˆt a 3-dimensional (3D) ellipsoid or tensor model. The direction of the main tensor axis (DTA) was used forˆber tracking.…”

Section: Single-and Multi-tensor Modelingmentioning

confidence: 99%

“…According to Yamada's method, 11 one neuroradiologist placed ROIs on each hemisphere. To trace the motor pathways of a single hemisphere, 5 ROIs were placed over the primary motor cortex (Fig.…”

Section: Placement Of Regions Of Interest (Roi)mentioning

confidence: 99%

“…1,[5][6][7][8] Thus, single-tensor tractography is limited to only part of the entire tract and is not ideal for correctly estimating the location of brainˆbers. [9][10][11] Because underestimation of motorˆbers in areas ofˆber-crossing can mislead the surgeon and result in serious damage to the pyramidal tract during surgery, 12 methods have been proposed to depict all bers. [13][14][15][16] Among these, high angular resolution diŠusion imaging (HARDI) may be valuable in a clinical setting.…”

Section: Introductionmentioning

confidence: 99%

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Multi-tensor Tractography of the Motor Pathway at 3T: A Volunteer Study

et al. 2011

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Conventional single-tensor tractography cannot depict the entire motor tract of the corticospinal tract because ofˆber-crossing and other factors. Using a 3-tesla magnetic resonance (MR) unit, we compared single-and multi-tensor methods for the tract ratio of the 5 major components of the motor pathway, the lower extremity, trunk, hand, face, and tongue, in 5 healthy volunteers. Multi-tensor tractography is better than single-tensor tractography at 3T in depicting moreˆbers of non-trunk areas from the primary motor cortex.

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Reconstructing the somatotopic organization of the corticospinal tract remains a challenge for modern tractography methods

He,

Zhang,

Pan

et al. 2023

Human Brain Mapping

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The corticospinal tract (CST) is a critically important white matter fiber tract in the human brain that enables control of voluntary movements of the body. The CST exhibits a somatotopic organization, which means that the motor neurons that control specific body parts are arranged in order within the CST. Diffusion magnetic resonance imaging (MRI) tractography is increasingly used to study the anatomy of the CST. However, despite many advances in tractography algorithms over the past decade, modern, state‐of‐the‐art methods still face challenges. In this study, we compare the performance of six widely used tractography methods for reconstructing the CST and its somatotopic organization. These methods include constrained spherical deconvolution (CSD) based probabilistic (iFOD1) and deterministic (SD‐Stream) methods, unscented Kalman filter (UKF) tractography methods including multi‐fiber (UKF2T) and single‐fiber (UKF1T) models, the generalized q‐sampling imaging (GQI) based deterministic tractography method, and the TractSeg method. We investigate CST somatotopy by dividing the CST into four subdivisions per hemisphere that originate in the leg, trunk, hand, and face areas of the primary motor cortex. A quantitative and visual comparison is performed using diffusion MRI data (N = 100 subjects) from the Human Connectome Project. Quantitative evaluations include the reconstruction rate of the eight anatomical subdivisions, the percentage of streamlines in each subdivision, and the coverage of the white matter–gray matter (WM–GM) interface. CST somatotopy is further evaluated by comparing the percentage of streamlines in each subdivision to the cortical volumes for the leg, trunk, hand, and face areas. Overall, UKF2T has the highest reconstruction rate and cortical coverage. It is the only method with a significant positive correlation between the percentage of streamlines in each subdivision and the volume of the corresponding motor cortex. However, our experimental results show that all compared tractography methods are biased toward generating many trunk streamlines (ranging from 35.10% to 71.66% of total streamlines across methods). Furthermore, the coverage of the WM–GM interface in the largest motor area (face) is generally low (under 40%) for all compared tractography methods. Different tractography methods give conflicting results regarding the percentage of streamlines in each subdivision and the volume of the corresponding motor cortex, indicating that there is generally no clear relationship, and that reconstruction of CST somatotopy is still a large challenge. Overall, we conclude that while current tractography methods have made progress toward the well‐known challenge of improving the reconstruction of the lateral projections of the CST, the overall problem of performing a comprehensive CST reconstruction, including clinically important projections in the lateral (hand and face areas) and medial portions (leg area), remains an important challenge for diffusion MRI tractography.

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Multitensor Tractography Enables Better Depiction of Motor Pathways: Initial Clinical Experience Using Diffusion-Weighted MR Imaging with Standard b-Value

Abstract: BACKGROUND AND PURPOSE:The purpose of this work was to test the feasibility of using high angular resolution diffusion imaging (HARDI)-based multitensor tractography to depict motor pathways in patients with brain tumors.

Cited by 33 publications

References 20 publications

Somatotopic Organization of Motor Pathways in the Internal Capsule: A Probabilistic Diffusion Tractography Study

Somatotopic Organization of Motor Pathways in the Internal Capsule: A Probabilistic Diffusion Tractography Study

Multi-tensor Tractography of the Motor Pathway at 3T: A Volunteer Study

Reconstructing the somatotopic organization of the corticospinal tract remains a challenge for modern tractography methods

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