1994
DOI: 10.1161/01.atv.14.12.1940
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Multivariate analysis of the insulin resistance syndrome in women.

Abstract: The insulin resistance syndrome (IRS) is characterized by a constellation of interrelated coronary heart disease (CHD) risk factors, including dyslipidemia, obesity, central obesity, elevated systolic blood pressure, and hyperinsulinemia. Factor analysis was used to investigate the clustering of these risk factors in individuals by examining the correlational structure among these variables. Data from 281 genetically unrelated nondiabetic women who participated in exam 2 (1979 to 1980) 23 However, the metab… Show more

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Cited by 154 publications
(130 citation statements)
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“…45 The phenotypic correlations estimated in this study are also consistent with the well-documented patterns between these lipids and lipoproteins. [23][24][25] For example, in a recent report from the Physicians' Health Study, the correlation for each possible pair of these variables was strong and highly statistically significant (PÏœ0.01): ÏȘ0.71 for TG and LDL size, ÏȘ0.57 for TG and HDL-C, and 0.61 for LDL size and HDL-C 3 compared with P Ï­ÏȘ0.66, P Ï­ÏȘ0.53, and P Ï­0.54, respectively, reported here.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…45 The phenotypic correlations estimated in this study are also consistent with the well-documented patterns between these lipids and lipoproteins. [23][24][25] For example, in a recent report from the Physicians' Health Study, the correlation for each possible pair of these variables was strong and highly statistically significant (PÏœ0.01): ÏȘ0.71 for TG and LDL size, ÏȘ0.57 for TG and HDL-C, and 0.61 for LDL size and HDL-C 3 compared with P Ï­ÏȘ0.66, P Ï­ÏȘ0.53, and P Ï­0.54, respectively, reported here.…”
Section: Discussionmentioning
confidence: 99%
“…Although the specific genetic bases of both FCHL and FHTG are poorly understood, studies indicate major gene effects on TG and apo B in FCHL families. 12,13 In addition, there is also considerable evidence for genetic influences on LDL subclass phenotypes 12,14 -18 and HDL-C. 19 -22 Statistical and physiological relationships between measures of LDL size, plasma TG, and HDL-C are well established 3,[23][24][25] and may represent a high-CHD-risk lipid/ lipoprotein phenotype with common underlying genetic influences. Sprecher et al 26,27 first proposed that the combination of high TG and low HDL-C constituted an inherited "conjoint trait" associated with increased risk of CHD in families of hypertriglyceridemic or hypercholesterolemic probands participating in the Lipid Research Clinics Family Study.…”
mentioning
confidence: 99%
“…There is some evidence that MetS has become more prevalent over the last decade (5,10,11) , probably influenced in part by increases in obesity, and this will worsen the public health burden of MetS-related morbidity and mortality. The aetiology of MetS, although not entirely understood, is considered to reside in a complex interaction between genetic, metabolic and environmental factors (12,13) . Understanding what factors are predictive of MetS and how these risk factors are distributed and interrelated within different populations is important for identifying and targeting populations at risk, thus helping in the development and implementation of public health interventions.…”
Section: Metabolic Syndrome Sociodemographic Risk Factors Mediterranementioning
confidence: 99%
“…People with diabetes were excluded, consistent with the previous analyses. 17,18 because diabetes is considered to be a consequence of, rather than a feature of, the Metabolic Syndrome. 17,19 Leptin assays were performed in 1996 using radioimmunoassay kits (Linco, St Louis, MO, USA).…”
Section: Survey Procedures and Analysesmentioning
confidence: 99%