Multivitamins preventive therapy against subclinical endometritis in buffaloes: Its correlation to NEFA and oxidative stress

Ahmed, Eman; Elsayed, Doaa H.; Kilany, Omnia; El-Beltagy, Marwa A.

doi:10.1016/j.repbio.2017.05.008

Cited by 13 publications

(7 citation statements)

References 41 publications

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“…Under energy-deficit conditions, NEFA enters into the hepatocellular mitochondria, where it is oxidized to produce energy. Meanwhile, the increased rate of NEFA oxidation generates excessive reactive oxygen species (ROS), for example, H 2 O 2 induction promotes the lipoperoxidative processes and changes the redox status [ 31 ]. The rise of MDA and H 2 O 2 may reflect a disturbance in the antioxidant defense mechanisms [ 32 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

Oxidative status in dairy goats: periparturient variation and changes in subclinical hyperketonemia and hypocalcemia

et al. 2021

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Background A better comprehension of the redox status during the periparturient period may facilitate the development of management and nutritional solutions to prevent subclinical hyperketonemia (SCHK) and subclinical hypocalcemia (SCHC) in dairy goats. We aimed to evaluate the variation in the redox status of dairy goats with SCHK and SCHC during their periparturient periods. Guanzhong dairy goats (n = 30) were assigned to SCHK (n = 10), SCHC (n = 10), and healthy (HEAL, n = 10) groups based on their blood β-hydroxybutyrate (BHBA) and calcium (Ca) concentrations. Blood were withdrawn from goats every week from 3 weeks before the expected parturition date to 3 weeks post-kidding. On the same day, the body condition scores (BCS) were evaluated, and the milk yield was recorded for each goat. The metabolic profile parameters and the indicators of oxidative status were determined by using the standard biochemical techniques. Results In comparison with the HEAL goats, SCHK and SCHC goats presented with a more dramatic decline of BCS post-kidding and a significant decrease in the milk yield at 2- and 3-weeks postpartum, ignoring the obvious increase at 1-week postpartum. The levels of non-esterified fatty acids (NEFA) peaked at parturition, exhibiting significantly higher levels from 1-week prepartum to the parturition day in the SCHK and SCHC groups. The malondialdehyde (MDA) concentration was increased in the SCHK goats from 1-week antepartum until 3-weeks postpartum, with its concentration being significantly higher in the SCHC goats at parturition. The hydrogen peroxide (H2O2) concentration was significantly lower in the SCHK and SCHC goats from 2-weeks antepartum to 1-week post-kidding. The total antioxidant capacity (T-AOC) and the superoxide dismutase (SOD) level were decreased at 1-week antepartum in the SCHK and SCHC goats, respectively. The glutathione peroxidase (GSH-Px) level was increased in the SCHK and SCHC goats during the early lactation period. Conclusions The SCHK and SCHC goats exerted more efforts to maintain their redox homeostasis and to ensure the production performance than the HEAL goats during their periparturient period, probably owing to more intense fat mobilization and lipid peroxidation in the former.

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Section: Discussionmentioning

confidence: 99%

Oxidative status in dairy goats: periparturient variation and changes in subclinical hyperketonemia and hypocalcemia

et al. 2021

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“…Later on, cytobrush was reinserted to the catheter before its withdrawal from uterus. The first one was smeared on glass microscope slide and fixed by cytofixative (Cytokeep ii, Alfresa pharma Co., Japan) according to Ahmed et al (2017). The second one was directly immersed in cryovial and kept in liquid nitrogen for endometrial TNF-α and IL-8 analysis.…”

Section: Blood and Endometrial Samplingmentioning

confidence: 99%

“…Based on the percentage of PMNs (threshold values of PMNs ≥ 6% at W5 or ≥ 4% at W7 pp. ), buffaloes (n=39) were categorized into SCE and non-SCE groups (Ahmed et al, 2017;Ghanem et al, 2016;Senosy and Hussein, 2013).…”

Section: Diagnosis Of Cytological Endometritis and Classification Of mentioning

confidence: 99%

Subclinical endometritis and postpartum ovarian resumption in respect to TNF-±, IL-8 and CRP in Egyptian buffaloes

Elsayed¹,

El-Azzazi²,

Mahmoud³

et al. 2020

Anim Reprod

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The study was carried out to find the relation between subclinical endometritis (SCE) and postpartum (pp.) ovarian resumption as well as to evaluate serum and endometrial TNF-α, IL-8 and serum CRP in buffaloes with and without SCE. Thirty-nine pluriparous buffaloes at the 3 rd (W3), 5 th (W5) and 7 th (W7) week pp. were involved in this experiment. The parity of the buffaloes ranged from 4 to 8 with an average 5.8±0.2. Subclinical endometritis was diagnosed by the percentage of polymorphonuclear cells (PMNs) in uterine cytology obtained from endometrial cytobrush at W5 and W7. The cutoff point of PMNs% in buffaloes for SCE was ≥ 6% at W5 or ≥ 4% at W7. According to PMNs%, buffaloes were divided into SCE group (n=27) and non-SCE group (n=12). Ovarian cyclicity was monitored by rectal palpation, ultrasonography and progesterone assay at W3, W5 and W7. Serum and endometrial TNF-α, IL-8 and serum CRP were estimated at W5 and W7. Buffaloes with SCE (55.6%) showed delayed ovarian activity as compared to non-SCE (16.7%) animals (P=0.036). Significant increase in serum cytokines and CRP levels were detected at W5 (P ˂0.05) and W7 (P <0.01) in SCE buffaloes as compared to non-SCE. Endometrial levels of cytokines were significantly (P ˂0.05) elevated in SCE buffaloes. Serum and endometrial cytokines showed significant positive correlation. Furthermore, levels of TNF-α, IL-8 and CRP exhibited significant positive correlation with PMNs%. In conclusion, SCE delayed postpartum ovarian cyclicity in buffaloes. Moreover, TNF-α, IL-8 and CRP assessments could be efficient tools in prediction of SCE in buffaloes.

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“…Abayawansa et al [125] reported a loss of weight during the first nine weeks postpartum of 14.7 and 14.5% for buffalo calving in winter and summer respectively; and more recently Reddy et al [127] observed a decrease in body weight from 625.7 ± 3.67 kg at calving to 551.55 ± 4.18 kg at day 90 postpartum, which represents a decrease of 11.85%. Loss of weight and body condition as a result of the decrease in dry matter intake and the increase in energy expenditure for milk synthesis results from the mobilization of fat reserves accumulated during the dry period, with the corresponding increase of NEFAs and BHB [126,127,[133][134][135][136][137][138][139].…”

Section: Body Condition Score and Negative Energy Balancementioning

confidence: 99%

“…Increased energy density in the diet using protected fat reduced the calving to conception interval [208], while supplementation with flaxseed reduced PFG2α secretion, increased progesterone level, and improved pregnancy rate after estrus synchronization [207]. Vitamin E, selenium and niacin has been observed to reduce postpartum anestrus [210,211] and oral administration of vitamins A, D3, and E from four weeks prepartum until the seventh week postpartum decreased the level of NEFAs at week 5 and 7 postpartum, improved the quality of vaginal mucus, decreased the incidence of subclinical endometritis and decreased the open days in comparison with the control group (97.50±15.75 vs. 152.1±24.45), all this was accompanied by decreases in oxidative stress of treated buffaloes [137]. The shortening of the dry period to < 60 days increased the capacity of adaptation of water buffaloes to postpartum metabolic and hormonal adjustments, decreasing the negative energy balance, meaning less of weight and BCS and lower levels of NEFAs and higher levels of glucose, and in consequence, a shortened interval to conception [138,212].…”

Section: Alternatives To Improve the Reproductive Performance Of Water Buffaloesmentioning

confidence: 99%

Reproductive Performance of Water Buffalo Cows: A Review of Affecting Factors

Nava-Trujillo¹,

Valeris-Chacín²,

Morgado-Osorio³

et al. 2020

J. Buffalo Sci.

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This article aims to review both the economic impact of reproductive failures on the profitability of water buffalo systems and the effect of different factors on the reproductive performance of water buffaloes. Besides, an overview of various non-hormonal alternatives to improve reproductive performance is made. The optimal reproductive efficiency in water buffaloes implies calving to conception interval around 90 days to reach a calving interval of 400 days, with longer calving intervals having a negative impact on profitability. Reproductive efficiency is the consequence of the interaction of genetic and non-genetic factors, and the recognition of these factors by analyzing the reproductive information must be a priority. Although each factor's impact can be of greater or lesser magnitude depending on the conditions of each herd, some factors like nutrition, milk yield, body condition score, negative energy balance, parity, bull presence, low estrus intensity, and season can be considered high-impact factors. Not all factors are common among farms; therefore each farm must implement a program for the identification, control, and prevention of reproductive problems, especially during early lactation, to prevent a long anestrus; and when artificial insemination is used, so that it is done at the correct time with respect to the beginning of estrus to enhance fertility.

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Multivitamins preventive therapy against subclinical endometritis in buffaloes: Its correlation to NEFA and oxidative stress

Cited by 13 publications

References 41 publications

Oxidative status in dairy goats: periparturient variation and changes in subclinical hyperketonemia and hypocalcemia

Oxidative status in dairy goats: periparturient variation and changes in subclinical hyperketonemia and hypocalcemia

Subclinical endometritis and postpartum ovarian resumption in respect to TNF-±, IL-8 and CRP in Egyptian buffaloes

Reproductive Performance of Water Buffalo Cows: A Review of Affecting Factors

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