Mumps meningoencephalitis: an epidemiological approach

Abstract

-The aim of this study was to analyse distribution of meningoencefalitis caused by mumps viras in children related to sex, age and seasonal influences. Thirty seven children were evaluated, ages ranging from 2 to 14 years. They were seen at Emergency Unit of Faculdade de Medicina do Triângulo Mineiro and at Hospital da Criança, in Uberaba-MG, Brazil, from March 1st 1991 to February 1st 1993 and they were hospitalized for about 5 days. Through a protocol findings were studied during hospitalization and clinical course stressing epidemiology, symptomatology, cerebrospinal fluid studies, electroencephalogram and cortical function analysis. Only epidemiological data were considered in the present study. Data analysis revealed male predominance, at a range from 5 to 9 years and great number of occurrences at the last quarter of the year.KEY WORDS: mumps meningoencephalitis, neuroepidemiology, aseptic meningoencephalitis. Meningoencefalite pelo vírus da caxumba: abordagem epidemiológicaRESUMO -O presente trabalho tem por objetivo, estudar a distribuição quanto ao sexo, idade e sazonalidade, em crianças com meningencefalite pelo vírus da caxumba. Foram avaliadas 37 crianças, com idades variando de 2 a 14 anos, atendidas no Pronto-Socorro do Hospital Escola da FMTM e do Hospital da Criança, MG, no período de 1-março-1991 a 1-fevereiro-1993 e hospitalizadas por período médio de 5 dias. Através de protocolo pré-elaborado foram estudados os achados obtidos por ocasião da internação e evolução, enfatizando-se a epidemiologia, sintomatologia, líquido cefalorraqueano, eletrencefalograma e função cortical. São considerados apenas os dados epidemiológicos, no presente estudo. A análise das informações pertinentes revela predomínio no sexo masculino, na faixa etária dos 5 aos 9 anos e maior número de casos no último trimestre do ano, correspondente à estação da primavera.PALAVRAS-CHAVE: meningencefalite pelo vírus da caxumba, neuroepidemiologia, meningencefalite asséptica.Mumps virus is one of the most frequent agents causing aseptic meningoencephalitis in patients under 15 years old. Nevertheless, the real incidence is clinically difficult to establish because it occurs asymptomatically (36%) 3 or in the absence of parotiditis (29%) 26 . Cerebrospinal fluid (CSF) studies in patients with epidemic parotiditis show pleocytosis ranging from 34% (26/77) 4 to 63% (235/371) 3 . Mumps virus belongs to genus Paramyxovirus, family Paramyxoviridae, and possess one RNA molecule. Two surface glucoproteins (HN and F) were described, which are essential for Este estudo faz parte da Dissertação de Mestrado do primeiro autor, apresentada à

Effect of age on the incidence of aseptic meningitis following immunization with monovalent mumps vaccine

“…We also performed stratified comparisons using Mantel-Haenszel statistics to adjust for sex because male sex has been shown to be a risk for neurological manifestations following mumps virus infection [6,17]. Analyses were conducted using the SPSS software package, version 17.0 (SPSS Inc., Chicago, IL, USA).…”

Seroepidemiology of the recent mumps virus outbreaks in Ireland

“…[16][17][18] Analysis of the ratio of males to females infected with mumps in Ireland from 2004 to 2009 revealed a clear and highly statistically significant gender bias (p < 0.01) with males accounting for 60.3% of mumpsspecific IgM positive patients. 10 Furthermore, the Central Statistics Office estimates that 61% of 19 years olds in tertiary education in Ireland are female, suggesting that the gender bias is not due to behavioral patterns as observed in other studies.…”

Molecular Epidemiological Evaluation of the Recent Resurgence in Mumps Virus Infections in Ireland

“…Interestingly, there is a gender bias for neurological manifestations, with males disproportionately affected (ca. 3:1 male/female ratio) (17,18,20).…”