Mumps Outbreak in the Republic of Moldova, 2007–2008

Schwarz, Norbert; Bernard, Helen; Melnic, A.; Bucov, Victoria; Caterinciuc, Natalia; Heiden, Matthias an der; Andrews, Nick; Pebody, Richard; Aidyralieva, Chinara; Hahné, Susan

doi:10.1097/inf.0b013e3181d743df

Cited by 31 publications

(17 citation statements)

References 24 publications

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“…[20][21][22][23] Very few studies have explored the relationship between meteorological factors and the incidence of mumps. To the best of our knowledge, this study is the first to apply a DLNM which simultaneously estimates the nonlinear and delayed effects to evaluate the effects of meteorological factors on the mumps incidence in China.…”

Section: Discussionmentioning

confidence: 99%

“…Although routine vaccination has resulted in a sharp decrease in the number of reported mumps cases, 2 there have been resurgences and large-scale outbreaks of mumps in many countries over the past decade, even in vaccinated population. [3][4][5][6][7][8][9] A total of 909 087 mumps cases were reported during 2008-2010, and up to 81.8% of the cases were children aged 3-14 y in China, in which mumps is categorized as a class "C" infectious disease. 10 The international measles-mumps-rubella (MMR) vaccine was introduced in Guangzhou in 1990.…”

Section: Introductionmentioning

confidence: 99%

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The relationship between meteorological factors and mumps incidence in Guangzhou, China, 2005–2012:

Yang

Ding³

et al. 2014

Human Vaccines & Immunotherapeutics

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The relationship between meteorological factors and mumps incidence in Guangzhou, China, 2005–2012:

Yang

Ding³

et al. 2014

Human Vaccines & Immunotherapeutics

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“…15 Waning of vaccine-induced immunity has been suggested to play a role in these outbreaks. [6][7][8][9][10]13,14 When compared to the other components in the MMR vaccine, the mumps component seemed to be the least effective in eliciting good (high avidity) antibody responses, which were shown to wane to lower levels and in avidity index 20 y after a second MMR vaccination. 16 Furthermore, vaccine-induced antibody concentrations measured against a (heterologous) genotype G virus were shown to be approximately one half the concentrations measured against the vaccine strain (genotype A; Jeryl Lynn).…”

Section: Introductionmentioning

confidence: 99%

“…2,3 Although it was assumed that mumps vaccination induces life-long protection, 4 several mumps outbreaks, especially among vaccinated student populations, have been reported during the last decade in various countries where mumps vaccination has been implemented into their national immunization programs. [5][6][7][8][9][10][11][12][13][14] In 2009-2012, a mumps epidemic (genotype G) arose that spread across multiple locations within the Netherlands, in which also primarily vaccinated students were affected. 15 Waning of vaccine-induced immunity has been suggested to play a role in these outbreaks.…”

Section: Introductionmentioning

confidence: 99%

Dynamics of the serologic response in vaccinated and unvaccinated mumps cases during an epidemic

Kaaijk

Gouma

Hulscher

et al. 2015

Human Vaccines & Immunotherapeutics

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Abbreviations: MMR, measles mumps and rubella; ND 50 , reciprocal virus-neutralizing antibody dose; VN, virus-neutralizing antibody; RU/ml, RIVM units per ml; GMC, geometric mean concentration; 95% CI, lower and upper 95% confidence intervals of GMCIn the last decade, several mumps outbreaks were reported in various countries despite high vaccination coverage. In most cases, young adults were affected who have acquired immunity against mumps solely by vaccination and not by previous wild-type mumps virus infection. To investigate mumps-specific antibody levels, functionality and dynamics during a mumps epidemic, blood samples were obtained longitudinally from 23 clinical mumps cases, with or without a prior history of vaccination, and from 20 healthy persons with no serological evidence of recent mumps virus infection. Blood samples from mumps cases were taken 1-2 months and 7-10 months after onset of disease. Both vaccinated and unvaccinated mumps cases had significantly higher geomean concentrations of mumps-specific IgG (resp. 13,617 RU/ml (95% CI of 9,574-19,367 RU/ml) vs. 1,552 (445-5412) RU/ml at 1-2 months; and 6,514 (5,247-8,088) RU/ml vs. 1,143 (480-2,725) RU/ml at 7-10 months) than healthy controls (169 (135-210) RU/ml) (p D 0.001). Patterns in virus-neutralizing (VN) antibody responses against the mumps vaccine virus were similar, vaccinated and unvaccinated mumps cases had significantly higher ND 50 values at both time points of sampling (resp 4,695 (3,779-5,832) RU/ml vs. 1,533 (832-2,825) RU/ml at 1-2 months; 2,478 (1,968-3,122) RU/ml vs. 1,221 (1,029-1,449) RU/ml at 7-10 months) compared with (previously vaccinated) healthy controls (122 (196-76)) RU/ml) (p D 0.001) The unvaccinated mumps cases had significantly lower mumps-specific IgG and VN antibody concentrations at both sampling points compared with previously vaccinated cases, but their antibody concentrations did not differ significantly at the 2 time points. In contrast, the mumps-specific IgG and VN antibody concentrations of the previously vaccinated mumps cases were significantly higher within the first 2 months after onset of mumps and declined thereafter, characteristic for a secondary response. A moderate correlation was found between the level of mumps-specific IgG serum antibodies and VN antibodies for the mumps cases (r D 0.64; p<0.001).

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“…Mumps outbreaks among two-dose vaccine recipients are not unique to the United States or to the Jeryl Lynn vaccine strain (the only licensed mumps vaccine in the United States). In fact, mumps outbreaks among vaccinated populations have occurred in numerous countries, some of which utilize different strains of vaccine virus (5)(6)(7)(8)(9)(10)(11)(12).…”

mentioning

confidence: 99%

Estimates of Mumps Seroprevalence May Be Influenced by Antibody Specificity and Serologic Method

Latner

McGrew

Williams

et al. 2013

Clin. Vaccine Immunol.

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Neutralizing antibodies are assumed to be essential for protection against mumps virus infection, but their measurement is labor-and time-intensive. For this reason, enzyme-linked immunosorbent assays (ELISAs) are typically used to measure mumpsspecific IgG levels. However, since there is poor correlation between mumps neutralization titers and ELISAs that measure the presence of mumps-specific IgG levels, ELISAs that better correlate with neutralization are needed. To address this issue, we measured mumps antibody levels by plaque reduction neutralization, by a commercial ELISA (whole-virus antigen), and by ELISAs specific for the mumps nucleoprotein and hemagglutinin. The results indicate that differences in the antibody response to the individual mumps proteins could partially explain the lack of correlation among various serologic tests. Furthermore, the data indicate that some seropositive individuals have low levels of neutralizing antibody. If neutralizing antibody is important for protection, this suggests that previous estimates of immunity based on whole-virus ELISAs may be overstated.

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Mumps Outbreak in the Republic of Moldova, 2007–2008

Abstract: Background: Moldova experienced a nationwide mumps outbreak in 2007

Cited by 31 publications

References 24 publications

The relationship between meteorological factors and mumps incidence in Guangzhou, China, 2005–2012:

The relationship between meteorological factors and mumps incidence in Guangzhou, China, 2005–2012:

Dynamics of the serologic response in vaccinated and unvaccinated mumps cases during an epidemic

Estimates of Mumps Seroprevalence May Be Influenced by Antibody Specificity and Serologic Method

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