Mupirocin resistance among Malaysian isolates of methicillin-resistant Staphylococcus aureus

Ahmad, Norazah; Koh, Y.T.; Kamel, A. G. M.; Alias, Rahmah; Lim, Victor

doi:10.1016/s0924-8579(01)00314-4

Cited by 19 publications

(19 citation statements)

References 19 publications

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“…The mupirocin resistance among the S. aureus clinical isolates is very low in many countries (4). In this investigation, all of the S. aureus isolates were sensitive to mupirocin, and similar results have been shown by Mohajeri et al from western Iran (14).…”

Section: Discussionsupporting

confidence: 89%

“…It appears that the carriage of S. aureus in people's noses plays an important role in the epidemiology and pathogenesis of infections caused by S. aureus, and this status accounts for both community-acquired and nosocomial infections, affecting nearly 20% of the population (2). Nowadays, methicillin-resistant S. aureus (MRSA) strains are of concern within healthcare organizations and in the community, and the frequency of these isolates is widely variable from region to region (3,4). The nasal carriage of community-acquired MRSA (CA-MRSA) is associated with a much higher incidence of clinical manifestations in comparison to other S. aureus strains (5).…”

Section: Introductionmentioning

confidence: 99%

“…The nasal carriage of community-acquired MRSA (CA-MRSA) is associated with a much higher incidence of clinical manifestations in comparison to other S. aureus strains (5). The CA-MRSA isolates, in addition to the beta-lactams, demonstrate resistance to other antimicrobial agents such as mupirocin (4,6). Mupirocin, as an antibacterial agent (via binding to isoleucyl tRNA synthetase, preventing protein synthesis), has been used in the form of a topical ointment for the eradication of MRSA or methicillin-susceptible Staphylococcus aureus (MSSA) infections and colonization to prevent the spread of this pathogen (4, 7).…”

Section: Introductionmentioning

confidence: 99%

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Nasal Carriage and Resistance Pattern of Staphylococcus aureus Among Healthy Medical Students

Khashei¹,

Zamani²,

Mohammad³

et al. 2016

Jentashapir J Health Res

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Background: Staphylococcus aureus nasal carriage plays an important role in the epidemiology and pathogenesis of infections, and this status accounts for both community-acquired and nosocomial infections. Objectives: This study was conducted to determine the frequency of the nasal carriage of S. aureus in healthy medical students. Patients and Methods: This cross-sectional study was undertaken among medical students from August of 2012 until January of 2013. Nasal samples from both anterior nares were obtained from the subjects using sterile moistened swabs, and the isolates were identified as S. aureus by the standard microbiological tests. The antibiotic susceptibility profiles were determined by the disc diffusion method according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. Results: Out of the 200 nasal swabs obtained, the overall nasal carriage of S. aureus was 24.5% (49/200). The prevalences of the methicillin-susceptible and resistant Staphylococcus aureus nasal carriage were 20% (40/200) and 4.5% (9/200), respectively, while the antibiotic susceptibility tests revealed that all 49 S. aureus isolates were sensitive to mupirocin. Conclusions: Despite the higher frequency of S. aureus nasal carriage in the interns, compared to the first year students, the difference did not reach statistical significance. Therefore, attendance at medical centers cannot be considered a risk factor for increasing carriage.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Nasal Carriage and Resistance Pattern of Staphylococcus aureus Among Healthy Medical Students

Khashei¹,

Zamani²,

Mohammad³

et al. 2016

Jentashapir J Health Res

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“…Em diferentes áreas da Malásia, que têm uma política de uso restrito de mupirocina, observou-se baixa porcentagem de resistência (1,25%) entre 400 MRSA pesquisados (19) .…”

Section: Discussionunclassified

Resistência à mupirocina entre isolados de Staphylococcus aureus de profissionais de enfermagem

et al. 2010

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RESUMO ABSTRACT Objectives:To assess colonization by Staphylococcus aureus sensitive and resistant to methicillin found in the saliva of nurses and, to recognize the mupirocin profile of resistance. Methods: It was collected three saliva samples of 356 (94.2%) professional research participants, totaling 1068 samples processed. All ethical aspects were covered. Microbiological analysis included the phenotypic identification, according to the standards of the Clinical and Laboratory Standards Institute. Results: In the first collection were obtained 73 individuals colonized by Staphylococcus aureus, 48 in the second and 37 in the third, totaling 158 samples of Staphylococcus aureus. Of these, 24 (15.2%) were resistant to oxacillin and 30 resistant to mupirocin (18.9%). Mupirocin resistance was observed sharply in the Staphylococcus aureus resistant to methicillin (MRSA); of 24 MRSA, 17 (70.8%) were resistant to this antibiotic. Conclusion: The results indicated that mupirocin resistance is a major problem since this antibiotic is an excellent ally in the measures taken to control infection in health services. Keywords: Staphylococcus aureus; Drug resistance, multiple; Mupirocin ; Nursing team RESUMEN Objetivos: Evaluar la colonización por Staphylococcus aureus sensibles y resistentes al meticilín en la saliva de profesionales de enfermería y, reconocer el perfil de resistencia a la mupirocina. Métodos: Fueron recolectadas tres muestras de saliva de 356 (94,2%) profesionales participantes de la investigación, totalizando 1.068 muestras procesadas. Todos los aspectos éticos fueron contemplados. El análisis microbiológico comprendió la identificación fenotípica, según normas del Clinical and Laboratory Standards Institute. Resultados: Fueron obtenidos 73 individuos colonizados por Staphylococcus aureus en la primera recolección, 48 en la segunda y 37 en la tercera, sumando 158 muestras aisladas de Staphylococcus aureus. De esas, 24 (15,2%) eran resistentes a la oxacilina y 30 resistentes a al mupirocina (18,9%). La resistencia al mupirocina fue observada de forma pronunciada en los Staphylococcus aureus resistentes a la metacilina (MRSA); de los 24 MRSA, 17 (70,8%) se presentaron resistentes a este antimicrobiano. Conclusión: Los resultados indicaron que la resistencia a la mupirocina es un importante problema, ya que ese antibiótico es un excelente aliado en las medidas de control de las infecciones de servicios de salud.

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“…Since 1988, Malaysian hospitals have been using mupirocin to treat a wide spectrum of S. aureus skin/wound infections (Rohani et al 2000;Norazah et al 2001). Although reports of mupirocin resistant in MRSA are still sporadic, the number is rising slowly around the globe (Walker et al 2003, Yun et al 2003Norazah et al 2003).…”

Section: Isolatesmentioning

confidence: 99%

Detection of Methicillin-Resistant Staphylococcus aureus Using mecA/nuc Genes and Antibiotic Susceptibility Profile of Malaysian Clinical Isolates

Johari

Mohtar

Suhaili

et al. 2006

World J Microbiol Biotechnol

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The aim of this study is to compare methicillin-resistant Staphylococcus aureus (MRSA) detection methods and to generate antibiogram profile of S. aureus clinical isolates from two teaching hospitals in Malaysia including three reference isolates from American Type Culture Collection (ATCC). The mecA/nuc gene PCR amplification, spot inoculation test and oxacillin disc diffusion test were applied to compare its MRSA detection abilities. No disagreement between the three methods was observed. From 29 bacterial isolates (including the ATCC strains) tested, 19 isolates were confirmed as S. aureus with 14 isolates exhibiting multidrug-resistance. All isolates are still susceptible to vancomycin as indicated by the E-test result. Current biochemical tests are comparable with the molecular detection method for MRSA used in this study while multidrug-resistance traits are present in both MRSA and MSSA clinical isolates. Presently, mupirocin seems to be the best alternative for vancomycin against multidrug-resistant S. aureus infections in Malaysia. Susceptibility profile of 19 S. aureus isolates acquired from two teaching hospitals and ATCC towards 16 selected antibiotics was analyzed and an antibiogram was generated. Findings also indicated resistance against many of the available antibiotics and thus an urgent need to search for alternative antibiotics.

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Mupirocin resistance among Malaysian isolates of methicillin-resistant Staphylococcus aureus

Cited by 19 publications

References 19 publications

Nasal Carriage and Resistance Pattern of Staphylococcus aureus Among Healthy Medical Students

Nasal Carriage and Resistance Pattern of Staphylococcus aureus Among Healthy Medical Students

Resistência à mupirocina entre isolados de Staphylococcus aureus de profissionais de enfermagem

Detection of Methicillin-Resistant Staphylococcus aureus Using mecA/nuc Genes and Antibiotic Susceptibility Profile of Malaysian Clinical Isolates

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