Mural Thrombus and the Progression of Abdominal Aortic Aneurysms: A Large Population-based Prospective Cohort Study

Behr-Rasmussen, Carsten; Grøndal, N.; Bramsen, M.B.; Thomsen, M.D.; Lindholt, Jes Sanddal

doi:10.1016/j.ejvs.2014.05.014

Cited by 88 publications

(91 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In 9 studies, AAA diameter was described as a marker for expansion8, 17, 19, 21, 40, 56, 57, 58, 59 and in 9 as a marker for rupture 34, 37, 60, 61, 62, 63, 64, 65, 66. Overall, the data are reliable because 2570 patients in total were included and 8 studies were appraised with low bias risk, 7 with medium risk, and only 3 with high risk.…”

Section: Resultsmentioning

confidence: 99%

“…Overall, the data are reliable because 2570 patients in total were included and 8 studies were appraised with low bias risk, 7 with medium risk, and only 3 with high risk. In 7 studies, significant correlations with expansion were demonstrated in 958 patients in total ( r =0.30–0.83),8, 21, 40, 56, 57, 58 and Norman et al measured faster growth in patients with a large (≥4 cm; n=112) versus small AAA (3–4 cm; n=433) 19. In 6 studies, with a total of 552 patients, significant outcomes were demonstrated for AAA diameter as a marker for rupture.…”

Section: Resultsmentioning

confidence: 99%

“…We designated this marker as promising because of a clear association of ILT volume with expansion, even though relatively small patient numbers were included in only 2 studies. However, Kontopodis, Nguyen, and Behr‐Rahsmussen et al also demonstrated the ILT to be correlated with AAA expansion in 694 follow‐up patients in total (ie, ILT thickness, signal intensity, and surface area, respectively) 57, 71, 91. In total, 5 studies have elaborated on ILT size as a marker for expansion in 758 patients, with, on average, a medium bias risk.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Systematic Review of Circulating, Biomechanical, and Genetic Markers for the Prediction of Abdominal Aortic Aneurysm Growth and Rupture

Groeneveld

Meekel

Rubinstein

et al. 2018

JAHA

View full text Add to dashboard Cite

BackgroundThe natural course of abdominal aortic aneurysms (AAA) is growth and rupture if left untreated. Numerous markers have been investigated; however, none are broadly acknowledged. Our aim was to identify potential prognostic markers for AAA growth and rupture.Methods and ResultsPotential circulating, biomechanical, and genetic markers were studied. A comprehensive search was conducted in PubMed, Embase, and Cochrane Library in February 2017, following Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines. Study selection, data extraction, and methodological quality assessment were conducted by 2 independent researchers. Plausibility of markers was based on the amount of publications regarding the marker (more than 3), pooled sample size (more than 100), bias risk and statistical significance of the studies. Eighty‐two studies were included, which examined circulating (n=40), biomechanical (n=27), and genetic markers (n=7) and combinations of markers (n=8). Factors with an increased expansion risk included: AAA diameter (9 studies; n=1938; low bias risk), chlamydophila pneumonia (4 studies; n=311; medium bias risk), S‐elastin peptides (3 studies; n=205; medium bias risk), fluorodeoxyglucose uptake (3 studies; n=104; medium bias risk), and intraluminal thrombus size (5 studies; n=758; medium bias risk). Factors with an increased rupture risk rupture included: peak wall stress (9 studies; n=579; medium bias risk) and AAA diameter (8 studies; n=354; medium bias risk). No meta‐analysis was conducted because of clinical and methodological heterogeneity.ConclusionsWe identified 5 potential markers with a prognostic value for AAA growth and 2 for rupture. While interpreting these data, one must realize that conclusions are based on small sample sizes and clinical and methodological heterogeneity. Prospective and methodological consonant studies are strongly urged to further study these potential markers.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Systematic Review of Circulating, Biomechanical, and Genetic Markers for the Prediction of Abdominal Aortic Aneurysm Growth and Rupture

Groeneveld

Meekel

Rubinstein

et al. 2018

JAHA

View full text Add to dashboard Cite

show abstract

“…As outlined in Figure 1, our search identified 20 eligible studies [3][4][5][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] reporting the association of CAD and AAA growth, which included data on a total of 7238 AAA patients. The study design and patient characteristics, detailed measurements of AAA diameters, and growth rates of AAA are summarized in Tables 1, 2, and 3, respectively.…”

Section: Resultsmentioning

confidence: 99%

Coronary artery disease and abdominal aortic aneurysm growth

Takagi

Umemoto

2016

Vasc Med

View full text Add to dashboard Cite

To determine whether coronary artery disease (CAD) is associated with abdominal aortic aneurysm (AAA) growth, we performed a meta-analysis of currently available studies. Databases including MEDLINE and EMBASE were searched through October 2015 using PubMed and OVID. Search terms included enlargement, expansion, growth, or progression; rate or rates; and abdominal aortic aneurysm. Studies considered for inclusion met the following criteria: the design was unrestricted; the study population was AAA patients with and without CAD; and outcomes included data regarding AAA growth. For each study, growth rates in both the CAD and non-CAD groups were used to generate standardized mean differences (SMDs) and 95% confidence intervals (CIs). Of 664 potentially relevant publications screened initially, we identified 20 eligible studies including data on a total of 7238 AAA patients. A pooled analysis of all 20 studies demonstrated a statistically significant association of CAD with slower AAA growth rates (i.e. a significantly negative association of CAD with AAA growth) in the fixed-effect model (SMD, -0.06 [-0.0592]; 95% CI, -0.12 [-0.1157] to -0.00 [-0.0027]; p = 0.04). There was minimal between-study heterogeneity (p = 0.16) and a statistically non-significant association of CAD with slower AAA growth rates (i.e. a non-significantly negative association of CAD with AAA growth) in the pooled result from random-effects modeling (SMD, -0.06; 95% CI, -0.13 to 0.01; p = 0.12). In conclusion, CAD may be negatively associated with AAA growth.

show abstract

“…Of them, we identifi ed seven eligible studies [9][10][11][12][13][14][15] reporting the association of BMI and AAA growth rates, which included data on a total of 3,768 AAA patients. The patient and AAA characteristics, the details of diameter measurement, and the association between BMI and AAA growth rates are summarized in Table 1 In a prospective study by Burillo et al [13], 122 male patients with a >30 mm AAA were scanned annually with a mean observation time of 8.1 years.…”

Section: Resultsmentioning

confidence: 99%

The association between body mass index and abdominal aortic aneurysm growth: a systematic review

Takagi

Umemoto

2016

Vasa

View full text Add to dashboard Cite

Summary: Diabetes, a state of relative insulin resistance, is negatively associated with both the presence and growth abdominal aortic aneurysms (AAA), which could suggest a protective role of obesity against AAA presence or growth. A recent meta-analysis demonstrated a trend toward a positive, though statistically non-signifi cant, association between body mass index (BMI) and the presence of AAA. With respect to the association between obesity and AAA growth, however, the evidence had been very limited. To determine whether obesity (or BMI) is associated with AAA growth, we reviewed currently available studies with a systematic literature search. Our comprehensive search identifi ed seven eligible studies reporting the association of BMI and AAA growth rates, which included data on a total of 3,768 AAA patients. All seven identifi ed studies demonstrated no association between BMI and AAA growth. Despite a trend toward a positive association between BMI and AAA presence, the reason why BMI is not associated with AAA growth (suggested in the present review) is unclear. A discrepancy between associated comorbidities (coronary artery disease, peripheral artery disease, and chronic obstructive pulmonary disease) and AAA presence and between the same comorbidities and AAA growth, however, could be identifi ed. Further investigations are required to elucidate why BMI is not associated with AAA growth despite the trend for a positive association with AAA presence.

show abstract

Mural Thrombus and the Progression of Abdominal Aortic Aneurysms: A Large Population-based Prospective Cohort Study

Abstract: These findings suggest that ILT may play a part in the progression of AAAs.

Cited by 88 publications

References 17 publications

Systematic Review of Circulating, Biomechanical, and Genetic Markers for the Prediction of Abdominal Aortic Aneurysm Growth and Rupture

Systematic Review of Circulating, Biomechanical, and Genetic Markers for the Prediction of Abdominal Aortic Aneurysm Growth and Rupture

Coronary artery disease and abdominal aortic aneurysm growth

The association between body mass index and abdominal aortic aneurysm growth: a systematic review

Contact Info

Product

Resources

About