Murine immunomodulation by low-dose dietary deoxynivalenol and improved detection methods for deoxynivalenol

Landgren, Cindy A.

doi:10.31274/rtd-180815-379

DOI: 10.31274/rtd-180815-379

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Murine immunomodulation by low-dose dietary deoxynivalenol and improved detection methods for deoxynivalenol

Cindy A. Landgren

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In vivo toxicity assessment of deoxynivalenol-contaminated wheat after ozone degradation

Wang¹,

Wang

Shao³

et al. 2016

Food Additives & Contaminants: Part A

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The effect of ozone on deoxynivalenol (DON) detoxification was investigated. Ozone treatment could significantly reduce the levels of DON in wheat; 53% of DON in wheat was decomposed with 90 mg l of ozone at a flow rate of 15 l min for 4 h. The safety of DON-contaminated wheats (DCWs) untreated/treated by ozone was also evaluated. Institute of Cancer Research (ICR) mice were divided into a standard diet group and five experimental diet groups for a 51-day orally administration experiment. In the experiment, no remarkable changes in the general appearance of the mice were observed, and all the mice survived until the scheduled necropsy. The results of sub-chronic toxicity indicated that mice fed on DCWs alone had significantly decreased in body weight gain, thymus and spleen weights, ratios of liver, thymus and spleen to body weight, blood indices (red blood cell, haemoglobin, white blood cell), and pro-inflammatory cytokines (interleukin-6 (IL-6), tumour necrosis factor alpha (TNF-α)), while showing a significant increase in alanine aminotransferase, aspartate aminotransferase, blood creatinine and blood urea nitrogen levels. Histopathological examination indicate that DON elicited some degree of toxicity on the liver, kidney and thymus tissue. Mice fed on DCWs treated by ozone mitigated the adverse effects compared with mice fed on DCWs. All the results suggested that the deleterious effects of DON could be highly reduced by ozone, and ozone itself shows minor toxic effects on animals in this process.

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In vivo toxicity assessment of deoxynivalenol-contaminated wheat after ozone degradation

Wang¹,

Wang

Shao³

et al. 2016

Food Additives & Contaminants: Part A

View full text Add to dashboard Cite

show abstract

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Murine immunomodulation by low-dose dietary deoxynivalenol and improved detection methods for deoxynivalenol

Cited by 1 publication

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In vivo toxicity assessment of deoxynivalenol-contaminated wheat after ozone degradation

In vivo toxicity assessment of deoxynivalenol-contaminated wheat after ozone degradation

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