1983
DOI: 10.1002/jez.1402280210
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Murine trisomy: Developmental profiles of the embryo, and isolation of trisomic cellular systems

Abstract: Many questions related to the development and the phenotypic expression of trisomy (Ts) are amenable to systematic investigation in a mouse model that allows the induction of Ts 1 to 19 by a breeding design of mice heterozygous for Robertsonian metacentric chromosomes.

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Cited by 68 publications
(33 citation statements)
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“…Serial transfer poses a significant challenge to the replicative potential of HSCs and their progeny, causing the eventual exhaustion of even wild-type HSCs (Harrison and Astle 1982). Trisomy 16 and trisomy 19 FL-HSCs have been evaluated previously in primary transplantation (Herbst and Winking 1991); however, these studies were not performed on an isogenic background, and it is therefore difficult to determine whether the observed phenotypes were due to aneuploidy or factors such as graft rejection (Gropp et al 1983). …”
Section: Decreased Fitness Of Aneuploid Hscs Is Due To Decreased Prolmentioning
confidence: 99%
“…Serial transfer poses a significant challenge to the replicative potential of HSCs and their progeny, causing the eventual exhaustion of even wild-type HSCs (Harrison and Astle 1982). Trisomy 16 and trisomy 19 FL-HSCs have been evaluated previously in primary transplantation (Herbst and Winking 1991); however, these studies were not performed on an isogenic background, and it is therefore difficult to determine whether the observed phenotypes were due to aneuploidy or factors such as graft rejection (Gropp et al 1983). …”
Section: Decreased Fitness Of Aneuploid Hscs Is Due To Decreased Prolmentioning
confidence: 99%
“…A possible mechanism by which a cell deficiencv can arise is through an al tered cell cycle. However, stl.--ies on murine trisomies ::'2 and 19 showed no major differenl'es in the eell cycle and in the proliferative capacities of normal and trisomie cells (Gropp et al, 1983). Otherwise.…”
Section: B General Features Of Mouse Trisomiesmentioning
confidence: 90%
“…~lid" wi th i ts subsequent degeneration of the ocular ltns in murine trisomy 16 may be analogous to the lenticular (cdtarac~) anomalies in Down syndrome (Gropp et al, 1983).…”
Section: C the Phenotype Of Trisomy 16 Fetusesmentioning
confidence: 98%
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“…[67] Similarly, in mice, aneuploidy of autosomal chromosomes is not tolerated during embryonic development, with the exception of chromosome 19 which leads to death shortly after birth. [68] Thus, unlike low-grade mosaic CIN, systemic aneuploidies are not tolerated, except for a few trisomies, highlighting the importance of a euploid set of chromosomes, especially in the earliest phases of development.…”
Section: How Well Is Aneuploidy Tolerated In Vivo?mentioning
confidence: 99%