Muscle Activation During Peripheral Nerve Field Stimulation Occurs Due to Recruitment of Efferent Nerve Fibers, Not Direct Muscle Activation

Frahm, Ken Steffen; Hennings, Kristian; Vera–Portocarrero, Louis P.; Wacnik, Paul W.; Mørch, Carsten Dahl

doi:10.1111/ner.12466

Cited by 7 publications

(3 citation statements)

References 29 publications

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“…Key determinants of effectiveness have been found to include depth and orientation of the lead. AEs include lead migration and failure . McRoberts et al reported the results of a prospective multicenter trial of percutaneously placed cylindrical PNfS leads to treat axial spine pain .…”

Section: Causation and Reduction Of Neurological Complicationsmentioning

confidence: 99%

The Neurostimulation Appropriateness Consensus Committee (NACC) Safety Guidelines for the Reduction of Severe Neurological Injury

Deer¹,

Lamer

Pope³

et al. 2017

Neuromodulation: Technology at the Neural Interface

109

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Section: Causation and Reduction Of Neurological Complicationsmentioning

confidence: 99%

The Neurostimulation Appropriateness Consensus Committee (NACC) Safety Guidelines for the Reduction of Severe Neurological Injury

Deer¹,

Lamer

Pope³

et al. 2017

Neuromodulation: Technology at the Neural Interface

109

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“…Physiologically nerve fibers innervate the muscle cells at the motor point. Without this endplate apparatus and the signal amplifying effects of the nerve-muscle synapse, the electrical signal has to be substantially heightened to achieve whole muscle contractions [12], with a threshold increased an order of magnitude higher than required for nerve activation in cats [18], or in human model [19]. If correct, then nerve action will appear long before muscle activation with the latter requiring intensities that potentially can damage nearby tissue [19].…”

Section: Discussionmentioning

confidence: 99%

Why Temporal Inference Stimulation May Fail in the Human Brain: A Pilot Research Study

Iszak,

Gronemann,

Meyer

et al. 2023

Biomedicines

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Temporal interference stimulation (TIS) aims at targeting deep brain areas during transcranial electrical alternating current stimulation (tACS) by generating interference fields at depth. Although its modulatory effects have been demonstrated in animal and human models and stimulation studies, direct experimental evidence is lacking for its utility in humans (in vivo). Herein, we directly test and compare three different structures: firstly, we perform peripheral nerve and muscle stimulation quantifying muscle twitches as readout, secondly, we stimulate peri-orbitally with phosphene perception as a surrogate marker, and thirdly, we attempt to modulate the mean power of alpha oscillations in the occipital area as measured with electroencephalography (EEG). We found strong evidence for stimulation efficacy on the modulated frequency in the PNS, but we found no evidence for its utility in the CNS. Possible reasons for failing to activate CNS targets could be comparatively higher activation thresholds here or inhibitory stimulation components to the carrier frequency interfering with the effects of the modulated signal.

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“…Statistically significant improvements were also seen across other parameters, including the Oswestry Disability Questionnaire, the Becks Depression Inventory, and the Short Form-12 item Health survey. Of the enrolled subjects 9.6% of the subjects experienced complications requiring surgical intervention [95]. Guentchev et al also recently reported on the utility of PNS in managing sacroiliac joint (SIJ) pain [96].…”

Section: Methodsmentioning

confidence: 99%

Neurostimulation for Intractable Chronic Pain

et al. 2019

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The field of neuromodulation has seen unprecedented growth over the course of the last decade with novel waveforms, hardware advancements, and novel chronic pain indications. We present here an updated review on spinal cord stimulation, dorsal root ganglion stimulation, and peripheral nerve stimulation. We focus on mechanisms of action, clinical indications, and future areas of research. We also present current drawbacks with current stimulation technology and suggest areas of future advancements. Given the current shortage of viable treatment options using a pharmacological based approach and conservative interventional therapies, neuromodulation presents an interesting area of growth and development for the interventional pain field and provides current and future practitioners a fresh outlook with regards to its place in the chronic pain treatment paradigm.

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Muscle Activation During Peripheral Nerve Field Stimulation Occurs Due to Recruitment of Efferent Nerve Fibers, Not Direct Muscle Activation

Cited by 7 publications

References 29 publications

The Neurostimulation Appropriateness Consensus Committee (NACC) Safety Guidelines for the Reduction of Severe Neurological Injury

The Neurostimulation Appropriateness Consensus Committee (NACC) Safety Guidelines for the Reduction of Severe Neurological Injury

Why Temporal Inference Stimulation May Fail in the Human Brain: A Pilot Research Study

Neurostimulation for Intractable Chronic Pain

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