Muscle activity during a dash shown by 18F-fluorodeoxyglucose positron emission tomography

Ohnuma, Masahiro; Sugita, Takehiko; Kokubun, S.; Yamaguchi, Keiichiro; Rikimaru, H.

doi:10.1007/s00776-005-0972-y

Cited by 22 publications

(15 citation statements)

References 9 publications

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“…Although mapping based on needle electromyography (EMG) is the most widely used method for identifying dystonic muscles in PCD, the poor localization of target muscles is a major cause of treatment failure [1,5]. Application of PET images to evaluate muscular metabolic activity has been reported to be a useful strategy [13][14][15][16]. A recent study showed 18 F-FDG PET/CT could be effectively applied to localize dystonic muscles in PCD patients [17], however, 18 F-FDG PET/CT was not compared with the EMG mapping data in this study.…”

Section: Discussionmentioning

confidence: 99%

“…Application of PET images to evaluate muscular metabolic activity has been reported to be a useful strategy [13][14][15][16]. A recent study showed 18 F-fluorodeoxyglucose (FDG) PET/CT could be effectively applied to localize dystonic muscles in PCD patients [17], however, 18 F-FDG PET/CT was not compared with the EMG mapping data in this study.…”

Section: Introductionmentioning

confidence: 92%

“…Comparison of 18 F-FDG PET/CT with EMG mapping to localize dystonic superficial cervical muscles is needed. It is well-known that glucose metabolism and 18 F-FDG uptake are enhanced in contracting skeletal muscles [13][14][15], and thus, it has been suggested that the degree of 18 F-FDG uptake might be associated with the contraction strength of skeletal muscles [13][14][15]. Moreover, a recently developed integrated PET/CT method was found to provide both metabolic and anatomic information on hypermetabolic lesions.…”

Section: Introductionmentioning

confidence: 99%

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Comparison between 18F-FDG PET/CT and EMG Mapping for Identifying Dystonic Superficial Muscles in Primary Cervical Dystonia: Preliminary Results

Jang

Choi

Sung

et al. 2010

Nucl Med Mol Imaging

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Purpose This study was conducted to compare 18 F-FDG PET/CT and electromyography (EMG) mapping in patients with primary cervical dystonia (PCD) to find dystonic superficial cervical muscles. Methods Ten consecutive patients with PCD (M:F=5:5, age 44±13 years) whose dystonic posture was not relieved with conventional muscle relaxant therapy were included. Target cervical muscles for the comparison between 18 F-FDG PET/CT and EMG mapping were four representative superficial bilateral cervical muscles: splenius capitis muscle, sternocleidomstoid muscle, upper trapezius muscle, and leavator scapulae muscle. The diagnostic efficacy was compared between 18 F-FDG PET/CT and EMG mapping using physical exam and measurement of rotation angle as the gold standard. Results Among 80 muscles evaluated, there were 21 (26%) dystonic superficial cervical muscles assessed with physical exam and motion analysis. The sensitivity, specificity, and accuracy for localizing dystonic muscles were 76, 92, and 88% for 18 F-FDG PET/CT, and 95, 66, and 74% for EMG mapping, respectively. The sensitivity of EMG mapping was significantly higher than that of 18 F-FDG PET/CT. In contrast, 18 F-FDG PET/CT was significantly superior to EMG mapping for specificity and accuracy. Conclusions 18 F-FDG PET/CT is more specific and accurate than EMG mapping for finding superficial dystonic cervical muscles. The high sensitivity of EMG mapping suggests that 18 F-FDG PET/CT and EMG mapping are complementary for finding dystonic superficial cervical muscles.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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Comparison between 18F-FDG PET/CT and EMG Mapping for Identifying Dystonic Superficial Muscles in Primary Cervical Dystonia: Preliminary Results

Jang

Choi

Sung

et al. 2010

Nucl Med Mol Imaging

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“…Besides the examples given here, we would like to stress the applicability of whole body 18 F-Fluorodeoxyglucose imaging as an investigational tool to characterize whole body muscle activity in vivo [168-176] or even tendon activity [177]. In a whole body approach both agonistic and antagonistic muscle groups can be evaluated and a metabolic quantification can be done.…”

Section: Discussionmentioning

confidence: 99%

A musculoskeletal model of low grade connective tissue inflammation in patients with thyroid associated ophthalmopathy (TAO): the WOMED concept of lateral tension and its general implications in disease

Moncayo¹,

Moncayo²

2007

BMC Musculoskelet Disord

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“…It is well known that glucose metabolism and 18 F-FDG uptake are enhanced in contracting skeletal muscles (13)(14)(15); therefore, it was suggested that the degree of 18 F-FDG uptake may be associated with the strength of contraction of skeletal muscles (13)(14)(15). Moreover, a recently developed integrated PET/CT method was found to provide both metabolic information and anatomic information on hypermetabolic lesions.…”

mentioning

confidence: 99%

Localization of Dystonic Muscles with 18F-FDG PET/CT in Idiopathic Cervical Dystonia

Sung¹,

Choi²,

Kim³

et al. 2007

Journal of Nuclear Medicine

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The purpose of this study was to investigate whether 18 F-FDG PET/CT is useful for localizing dystonic cervical muscles in patients with idiopathic cervical dystonia (ICD) by comparing disease severity before and disease severity after botulinum toxin (BT) injection into hypermetabolic muscles. Methods: Six patients with ICD underwent 18 F-FDG PET/CT. Dystonic muscles suitable for BT injection therapy were defined as those showing diffusely increased 18 F-FDG uptake. Results: Hypermetabolic cervical muscles were identified in all 6 patients. In 2 patients who underwent PET/CT both in a supine position and in a sitting position during 18 F-FDG uptake, abnormal hypermetabolic muscles were observed by PET/CT only when patients were in the sitting position with their heads and necks in the adopted abnormal involuntary posture. Symptoms were significantly improved in 4 patients who underwent BT injection therapy guided by PET/ CT and who were clinically monitored. Conclusion: 18 F-FDG PET/CT is potentially useful for identifying dystonic cervical muscles for BT therapy in patients with ICD.

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Muscle activity during a dash shown by 18F-fluorodeoxyglucose positron emission tomography

Cited by 22 publications

References 9 publications

Comparison between 18F-FDG PET/CT and EMG Mapping for Identifying Dystonic Superficial Muscles in Primary Cervical Dystonia: Preliminary Results

Comparison between 18F-FDG PET/CT and EMG Mapping for Identifying Dystonic Superficial Muscles in Primary Cervical Dystonia: Preliminary Results

A musculoskeletal model of low grade connective tissue inflammation in patients with thyroid associated ophthalmopathy (TAO): the WOMED concept of lateral tension and its general implications in disease

Localization of Dystonic Muscles with 18F-FDG PET/CT in Idiopathic Cervical Dystonia

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