Muscle and Tendon

Hulland, T. J.

doi:10.1016/b978-0-08-057133-1.50010-2

Cited by 86 publications

(92 citation statements)

References 218 publications

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“…No entanto, doses semelhantes, de 14 ou 16 mg/kg, quando fracionadas, respectivamente, em sete e quatro administrações diárias de 2 e 4m/kg, provocaram somente sinais clínicos discretos seguidos de recuperação. Embora existam indicações de que os antibióti-cos ionóforos tenham poder acumulativo (Hulland 1993), isso não pôde ser confirmado nesse experimento.…”

Section: Achados Histopatológicosunclassified

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Intoxicação experimental por narasina em bovinos

Wouters

Barros

1997

Pesq. Vet. Bras.

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Pesq. Vet. Bras. 17(2):82-88, abr./jun. 1997 82 SINOPSE.-Intoxicação por narasina foi induzida pela administração oral da droga a 11 bovinos. Desses, cinco tiveram morte espontânea, um foi sacrificado in extremis e outros cinco apresentaram sinais clínicos da toxicose, mas se recuperaram. Os sinais clínicos iniciaram entre 12 horas e 4 dias após ingestão da narasina e a duração do curso clínico variou de 24 horas até 9 dias. Houve anorexia, redução na intensidade e número de movimentos ruminais, fezes pastosas, ressequi- Experimental poisoning by narasin was induced in 11 calves through oral administration of the drug. Five calves died, one was killed in extremis and 5 recovered after presenting mild clinical signs of the toxicosis. The onset of clinical signs was 12 hours to 4 days after the administration of the drug and clinical courses lasted from 24 hours to 9 days. Clinical signs were anorexia, decreased intensity and frequency of ruminal movements. Consistency of the feces varied from dry to semiliquid or liquid. Affected calves were reluctant to move, had incoordinated and stiff gait, and dragged the point of the hooves while walking. There was sluggish masticatory movements with drooling of saliva and dysphagia. The intensity of cardiac sounds were increased and, in one case, the jugular was distended and pulsating. Some animals were depressed, presented dyspnea, polydipsia and groanings. One calf presented myoglobinuria. Main necropsy findings were in the myocardium and consisted of focal or diffuse pale irregular areas. Signs of heart failure such as pulmonary edema, hydrotorax and clotted blood in the left ventricle of the heart were also observed. Degenerative lesions characterized by pale areas were seen in the skeletal muscles of three calves, but were marked in only one. Most affected muscles were masseter, extrinsec muscles of the tongue, tensor fasciae latae, semitendinosus, semimembranosus, psoas, quadriceps femoris, infraspinatus and gastrocnemius. Main histopathological changes consisted of degenerative myopathy and cardiomyopathy characterized by vacuolization of myofibers, hyalin and flocular necrosis either associated or not with reparative events. Myofiber regeneration and fibrosis were observed respectively in the skeletal muscles and in the myocardium.INDEX TERMS: Narasin, ionophore antibiotic, cattle, pathology, toxicosis.

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Section: Achados Histopatológicosunclassified

“…Mioglobinúria tem sido descrita em associação à intoxicação por antibióticos ionóforos em bovinos ( Van Vleet et al 1983), ovinos (Newsholme et al 1983, Wouters et al 1997, suínos (Miskimins & Neiger 1996) e cães (Karsai et al 1990). A presença de mioglobina na urina é indicativa de dano muscular grave (Hulland 1993).…”

Section: Achados Histopatológicosunclassified

Intoxicação experimental por narasina em bovinos

Wouters

Barros

1997

Pesq. Vet. Bras.

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“…O perfil da doença, no homem e no cão, se caracteriza pelo ciclo de degeneração e regeneração das fibras musculares, até que se esgote a capacidade regenerativa e que a fibrose progressiva encontre-se estabelecida (Hulland 2003).…”

Section: Introductionunclassified

“…Podem ser observadas fibras musculares degeneradas de tamanho variado e fibrose, evoluindo para megaesôfago cervical, torácico ou ambos, na dependência da evolução do problema (Valentine et al 1990, Hulland 2003.…”

Section: Introductionunclassified

Imagem radiográfica da cavidade torácica de cães Golden Retriever acometidos pela distrofia muscular

et al. 2009

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RESUMO.-A distrofia muscular de Duchenne (DMD) é uma doença de origem genética, cuja principal manifestação clínica é enfraquecimento e atrofia progressiva dos músculos. Os cães da raça Golden Retriever podem apresentar distrofia muscular, com características genotípicas e fenotípicas muito próximas à distrofia muscular humana, sendo considerado o modelo animal mais apropriado para o estudo da DMD. Foram realizadas radiografias torácicas látero-laterais e dorsoventrais de 10 cães Golden Retriever afetados pela distrofia muscular, com o objetivo de relatar as alterações radiográficas associadas a essa patologia. O exame radiográfico da cavidade torácica evidenciou: (a) padrão pulmonar intersticial e alveolar predominante, (b) um quadro de pneumonia e edema pulmonar em fase inicial, (c) a cardiomegalia como o principal achado de comprometimento circulatório na cavidade torácica, (d) O megaesôfago torácico foi observado deslocando a traquéia e silhueta cardíaca ventralmente e, (e) a cúpula diafragmática apresentou modificação morfológi-ca, mostrando protrusão para o interior da cavidade torá-cica e hérnia hiatal, com deslocamento do estômago para o espaço mediastino caudal. (DMD) is a genetic disorder with clinical signs of muscular weaknesses and progressive atrophy. Golden Retriever dogs show similar genotypic and phenotypic characteristics to Human Muscular Dystrophy and are considered a proper animal model for DMD studies. Latero-lateral and dorso-ventral thoracic radiographies were obtained from 10 Golden Retriever dogs affected by muscular dystrophy, to investigate possible radiographic alterations. Thorax radiographic examination revealed (a) interstitial and alveolar pattern, (b) initial phases of pneumonia and pulmonary edema, (c) cardiomegaly as a principal alteration in the thoracic cavity, (d) megaesophagus displacing the trachea and heart silhouette, and (e) cranial protrusion of the diaphragm lining into the thorax with development of a hiatus hernia displacing the stomach to the caudal mediastinum. Postmortem examination showed pleural effusion, pulmonary emphysema, degenerative and metaplasic processes in the diaphragm and intercostal muscles. Radiographic examination was considered essential for the diagnosis of cardiac and respiratory disease in Golden Retriever dogs affected by muscular dystrophy, and to identify the primary pulmonary process and to provide the establishment of suitable therapeutic treatment, with a reserved prognosis in advanced stage of the disease.

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“…"content-markup(./author-grp [1]/aff|./author-grp [1]/dept-list)> Muscle atrophy typically leads to reduction in size of the affected muscle. 11,15,19 Less commonly, macroscopic enlargement of the atrophic muscle occurs due to replacement of muscle by fat and fibrous tissue, a condition known as muscular pseudohypertrophy. 19,21 Muscular pseudohypertrophy is well known in human medicine, but is poorly documented in veterinary medicine.…”

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Muscular Pseudohypertrophy (Steatosis) in a Bovine Fetus

2007

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Abstract. Muscular pseudohypertrophy was diagnosed in the cervical musculature of a full-term crossbred Simmental fetus delivered by fetotomy. Only head and cervical regions were submitted for pathologic examination; the rest of the fetal body was reportedly normal. The neck musculature of the fetus was markedly deformed by 23 cm and 18 cm in diameter, firm, spherical masses that consisted of enlarged and pale left splenius and right serratus ventralis cervicis muscle, respectively, covered by intact skin. Additionally, lipomatous masses were present within the cervical vertebral canal, compressing the spinal cord. Microscopically, the prominent muscular enlargement was due to massive adipose and fibrous connective tissue replacement of atrophic muscle. Focal myelodysplasia and astrocytosis affecting the grey matter was detected in the mid-cervical region of the spinal cord, accompanied by degeneration in the ascending and descending tracts of the remaining cord segments. Abnormal spinal cord development as a result of severe spinal cord compression by the lipomatous masses within the spinal canal leading to replacement of muscle by fat and fibrous tissue was considered to be the cause of the muscular malformation in this fetus.

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Muscle and Tendon

Cited by 86 publications

References 218 publications

Intoxicação experimental por narasina em bovinos

Intoxicação experimental por narasina em bovinos

Imagem radiográfica da cavidade torácica de cães Golden Retriever acometidos pela distrofia muscular

Muscular Pseudohypertrophy (Steatosis) in a Bovine Fetus

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