Muscle chloride channels.

Bretag, Allan H.

doi:10.1152/physrev.1987.67.2.618

Cited by 243 publications

(163 citation statements)

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“…The ability of outer muscle fibres to contract in the presence of 10·mmol·l -1 BAPTA, coupled with the absence of inward currents, both features in contrast to inner muscle, suggest that the two muscle types use different excitation-contraction coupling mechanisms. This may be an adaptation of outer muscle, which is of the red type, to sustained, aerobic activity, whereas the inner muscle, of the white type, is adapted to sporadic escape-type activity (Greer-Walker and Pull, 1975;Van Raamsdonk et al, 1979, 1987. In addition, the triad structure in red muscle is reported to be quite varied, and poorly developed (Peachey and Huxley, 1962;Peachey, 1965) compared to white muscle.…”

Section: Discussionmentioning

confidence: 99%

“…One was the 'Normal' solution that we used to voltage-clamp the fibres when investigating total currents. The second solution was a potassium gluconate-based solution containing only approximately 14·mmol·l -1 Cl -, a concentration that is close to physiological for these muscle fibres (Bretag, 1987). The current-clamp results for both solutions were indistinguishable, apart from a slight slowing of the kinetics when recording with the low Cl -solution.…”

Section: Action Potentials In Inner Musclementioning

confidence: 99%

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Sodium and potassium currents of larval zebrafish muscle fibres

Buckingham

Ali

2004

Journal of Experimental Biology

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.p.f.) are described. In inner muscle, the outward currents were half-activated at -1.0·mV and half-inactivated at -30.4·mV, and completely inactivated within 100·ms of depolarization. The inward currents of inner fibres were half-activated at -7.3·mV and half-inactivated at -74.5·mV and completely inactivated within 5·ms of depolarization. Inner muscle fibres were found to support action potentials, while no action potentials could be evoked in outer muscles. In inner muscle fibres, all tested levels of depolarizing current above a threshold value evoked only one action potential. However, spiking at frequencies of up to 200·cycles·s -1 was evoked by the injection of depolarizing pulses separated by short hyperpolarizing currents. We suggest that the properties of the inward sodium and outward potassium currents permit high frequency firing in response to a pulsatile depolarizing input of the kind expected in fast swimming, whilst safeguarding against tetany during a strong depolarization.

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Section: Discussionmentioning

confidence: 99%

Section: Action Potentials In Inner Musclementioning

confidence: 99%

Sodium and potassium currents of larval zebrafish muscle fibres

Buckingham

Ali

2004

Journal of Experimental Biology

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“…where P min is the minimum open probability, and the other symbols have the same meaning as in Equation 1. It is important to note from Equation 2 that V1 ⁄ 2 is the half-saturation, or inflection point, of the gating curve and is independent of P min .…”

Section: Methodsmentioning

confidence: 99%

Intracellular β-Nicotinamide Adenine Dinucleotide Inhibits the Skeletal Muscle ClC-1 Chloride Channel

Bennetts

Chen

et al. 2012

Journal of Biological Chemistry

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Background: Weakly voltage-dependent ClC-1 chloride channels regulate skeletal muscle excitability. Results: Intracellular NAD(H) altered the voltage dependence of ClC-1 gating, and specific mutations attenuated this effect. Conclusion: NAD(H) directly inhibits ClC-1 chloride channels by binding to intracellular domains. Significance: ClC-1 inhibition by NAD(H) may play an important role in muscle fatigue and the pathophysiology of myotonia congenita.

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“…In many cells, E Cl approximates E M , so that Cl -distribution appears predominantly passive. Thus, the opening of Cl -channels generally stabilizes the membrane potential [19] [20]. One example is the importance of excessive epithelial salt secretion in cystic fibrosis.…”

Section: Biomedical Importance Of Chloride Channelsmentioning

confidence: 99%

Synthetic, Biologically Active Amphiphilic Peptides

Yamnitz

Gokel

2007

Chemistry & Biodiversity

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Amphiphilic peptides typically consist of a peptide portion that may be 5-25 (or more) amino acids in length. The hydrophobic portion may be a single fatty acid residue, but can also be more elaborate. The main focus of this article lies on the family of synthetic anion binders (SATs) of the general structure (R 1 ) 2 N-COCH 2 OCH 2 CO-(Aaa) n -OR 3 . The most-common R 1 groups are octadecyl (C 18 H 37 ). The most studied peptide sequence in this family is (Gly) 3 -Pro-(Gly) 3 , although different sequences (and longer and shorter peptides) have been prepared as well. The C-terminal ester residue providing the most effective anion release from liposomes is heptyl (C 7 H 15 ), although many others have been examined. The compound (C 18 H 37 ) 2 N-COCH 2 OCH 2 CO-(Gly) 3 -Pro-(Gly) 3 -OBn (Bn=benzyl) was found to mediate Cl -transport in mouse epithelial cells.

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Muscle chloride channels.

Cited by 243 publications

References 0 publications

Sodium and potassium currents of larval zebrafish muscle fibres

Sodium and potassium currents of larval zebrafish muscle fibres

Intracellular β-Nicotinamide Adenine Dinucleotide Inhibits the Skeletal Muscle ClC-1 Chloride Channel

Synthetic, Biologically Active Amphiphilic Peptides

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