Muscle mass and function in thyrotoxic patients before and during medical treatment

Nørrelund, Helene; Hove, Karen Yde; Brems-Dalgaard, E; Jurik, Anne Grethe; Nielsen, Lars Peter; Nielsen, Søren; Nielsen, Strange; Jørgensen, Jens Otto Lunde; Weeke, Jørgen; Møller, Niels

doi:10.1046/j.1365-2265.1999.00861.x

Cited by 55 publications

(44 citation statements)

References 29 publications

(37 reference statements)

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“…However, there was no change in the residual volume and therefore it is likely that a true increase in the strength of the inspiratory muscle has occurred. Recently, Norrelund et al (21) assessed muscle mass of the thigh by computerised tomography and body composition in patients with thyrotoxicosis. A decrease in BMI and 20% reduction in skeletal muscle mass were observed during thyrotoxicosis, which reversed after 9 months of carbimazole therapy (21).…”

Section: Discussionmentioning

confidence: 99%

“…Recently, Norrelund et al (21) assessed muscle mass of the thigh by computerised tomography and body composition in patients with thyrotoxicosis. A decrease in BMI and 20% reduction in skeletal muscle mass were observed during thyrotoxicosis, which reversed after 9 months of carbimazole therapy (21). In the present study, although there was a significant increase in BMI following a mean interval of 5 months of carbimazole therapy, this was not accompanied by an increase in the diaphragm muscle thickness.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of diaphragmatic muscle weakness and dyspnoea in Graves' disease and their reversibility with carbimazole therapy

Goswami

Guleria²,

Gupta³

et al. 2002

European Journal of Endocrinology

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Objectives: Dyspnoea is a common complaint among patients with thyrotoxicosis. However, its causative mechanisms have not been identified. We assessed the role of thoracic diaphragmatic muscle weakness in dyspnoea among patients with active Graves' disease. Methods: Twenty-seven patients (19 female, 8 male) with active Graves' disease were assessed for the clinical severity of dyspnoea, functional (pressure generating capacity) and anatomical aspects (thickness and excursion) of the diaphragm at presentation. The severity of dyspnoea was assessed using a visual analogue scale (VAS) and the 6 min walk test. Lung function tests, diaphragmatic strength (sniff oesophageal pressure, SniffP oeso ), maximum inspiratory and expiratory pressures, diaphragmatic thickness and movements on real time ultrasonography were evaluated during normal and deep respiration. Twenty of the 27 patients were reassessed after achieving euthyroidism with carbimazole therapy at a mean interval of 5^2 months. Results: Reevaluation after carbimazole therapy revealed a significant reduction in dyspnoea on the VAS ð59^26 to 23^13%Þ: Patients covered a similar distance during the 6 min walk before and after euthyroidism. Significant improvement was observed in the vital capacity ð2:57^0:62 to 2:94^0:60 lÞ; forced expiratory volume in the first second ð2:21^0:49 to 2:45^0:47 lÞ; total lung capacity ð3:57^1:19 to 4:1^1:12 lÞ; diaphragmatic movement during deep respiration ð5:5^1:0 to 6:6^1:1 cmÞ and SniffP oeso ð68:7^23 to 93:1^25:2 cmH 2 OÞ: There was no significant change in the distance walked in 6 min, tidal volume, lung diffusion capacity and diaphragmatic thickness. There was no significant correlation between the net change in dyspnoea score and net change in lung function tests, diaphragmatic movement and SniffP oeso . Conclusions: Significant functional weakness of diaphragm muscle is present in patients with active Graves' disease. This weakness is more marked during a maximal respiratory manoeuvre, indicating a diminished diaphragmatic reserve which could be the cause of dyspnoea observed on exertion among patients with thyrotoxicosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prevalence of diaphragmatic muscle weakness and dyspnoea in Graves' disease and their reversibility with carbimazole therapy

Goswami

Guleria²,

Gupta³

et al. 2002

European Journal of Endocrinology

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“…Decreased shoulder and grip strength were also reported [8]. Nevertheless, proximal muscles seem to be affected much more than distal muscles [2,4,9].…”

Section: Introductionmentioning

confidence: 98%

“…The relationship between overt and subclinical hyperthyroidism and proximal skeletal muscle strength has been investigated previously [2,4,9]; however, effects of hyperthyroidism on distal muscles of the upper limb have not yet been demonstrated. Therefore, for the first time, we evaluated hand grip strength, dexterity, and function in patients with primary hyperthyroidism in this study.…”

Section: Introductionmentioning

confidence: 99%

Effects of hyperthyroidism on hand grip strength and function

İnal

Çarlı²,

Çanak

et al. 2015

J Rehabil Res Dev

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Abstract-Hyperthyroidism is a pathologic condition in which the body is exposed to excessive amounts of circulating thyroid hormones. Skeletal muscle is one of the major target organs of thyroid hormones. We evaluated hand grip strength and function in patients with overt hyperthyroidism. Fifty-one patients newly diagnosed with hyperthyroidism and 44 healthy controls participated in this study. Age, height, weight, and dominant hand of all participants were recorded. The diagnosis of hyperthyroidism was confirmed by clinical examination and laboratory tests. Hand grip strength was tested at the dominant hand with a Jamar hand dynamometer. The grooved pegboard test (PGT) was used to evaluate hand dexterity. The Duruöz Hand Index (DHI) was used to assess hand function. No significant differences were found in terms of clinical and demographic findings between the patients with hyperthyroidism and healthy controls (p > 0.05). Significant differences were found between the patients with hyperthyroidism and healthy controls regarding PGT and DHI scores (p < 0.05). Hyperthyroidism seemed to affect hand dexterity and function more than hand grip strength and seemed to be associated with reduced physical function more than muscle strength. This may also indicate that patients with hyperthyroidism should be evaluated by multidisciplinary modalities.

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“…Estas discrepâncias podem refletir diferenças na duração da doença, já que a maior mobilização de gordura pode ser uma característica mais proeminente na tireotoxicose prolongada. Finalmente, diferenças individuais na susceptibilidade ao hormônio tireoidiano, também devem ser consideradas como fator influenciando a relação entre os níveis hormonais e alterações na composição corporal no HT (7).…”

Section: Composição Corporalunclassified

Disfunção muscular esquelética e composição corporal no hipertireoidismo

Santos

Filho

Barreto

et al. 2002

Arq Bras Endocrinol Metab

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Skeletal Muscle Dysfunction and Body Composition in Hyperthyroidism.The purpose of this article is to review aspects of skeletal muscle dysfunction and body composition in hyperthyroidism. Hyperthyroidism is associated with general muscle weakness, which is part of the initial clinical manifestation of about 80% of patients, compromising their daily activities and quality of life. A factor that contributes for strength reduction is muscle atrophy, which usually tends to affect proximal muscle groups. In addition, hyperthyroidism is accompanied by weight loss due to consumption of muscle mass and adipose tissue. Studies have demonstrated that medical treatment is able to promote recovery of strength and slowly, endurance, defined as the capacity to sustain sub-maximal loads for prolonged periods, and that resistance training associated with medical treatment leads to a major gain of muscular strength and resistance in those patients. Although a standard body composition during weight recovery after treatment is not established, patients submitted to strength training show weight recovery associated mainly with muscle mass gain. (Arq Bras Endocrinol Metab 2002;46/6:626-631) Keywords: Hyperthyroidism; Skeletal muscle function; Body composition O HIPERTIREOIDISMOPORDOENÇADEG RAVESé a doença autoimune mais prevalente nos Estados Unidos (1) e acarreta alterações somáti -cas e metabólicas generalizadas. O estudo das alterações na função muscurevisão

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Muscle mass and function in thyrotoxic patients before and during medical treatment

Abstract: In conclusion we find that in patients with thyrotoxicosis muscle mass is reduced by approximately 20% and muscle strength by approximately 40% and that between 5 and 9 months elapse before normal muscle mass and function are reestablished.

Cited by 55 publications

References 29 publications

Prevalence of diaphragmatic muscle weakness and dyspnoea in Graves' disease and their reversibility with carbimazole therapy

Prevalence of diaphragmatic muscle weakness and dyspnoea in Graves' disease and their reversibility with carbimazole therapy

Effects of hyperthyroidism on hand grip strength and function

Disfunção muscular esquelética e composição corporal no hipertireoidismo

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