Muscle Mitochondrial Function in Patients with Type 2 Diabetes Mellitus and Peripheral Arterial Disease: Implications in Vascular Surgery

Pedersen, Beth Lilja; Bækgaard, N; Quistorff, Bjørn

doi:10.1016/j.ejvs.2009.04.014

Cited by 33 publications

(25 citation statements)

References 49 publications

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“…diabetes mellitus3, 4) and cardiovascular diseases (e.g. peripheral arterial disease (PAD)5, 6, 7). These observations, together with the fact that evaluation of muscle oxidative metabolism provides insight into personal training status,8, 9 have led to a considerable methodological development in medical imaging for non‐invasive assessment of muscle energy metabolism.…”

Section: Introductionmentioning

confidence: 99%

Dynamic ³¹P–MRSI using spiral spectroscopic imaging can map mitochondrial capacity in muscles of the human calf during plantar flexion exercise at 7 T

et al. 2016

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Phosphorus MRSI (31P–MRSI) using a spiral‐trajectory readout at 7 T was developed for high temporal resolution mapping of the mitochondrial capacity of exercising human skeletal muscle.The sensitivity and localization accuracy of the method was investigated in phantoms. In vivo performance was assessed in 12 volunteers, who performed a plantar flexion exercise inside a whole‐body 7 T MR scanner using an MR‐compatible ergometer and a surface coil. In five volunteers the knee was flexed (~60°) to shift the major workload from the gastrocnemii to the soleus muscle.Spiral‐encoded MRSI provided 16–25 times faster mapping with a better point spread function than elliptical phase‐encoded MRSI with the same matrix size. The inevitable trade‐off for the increased temporal resolution was a reduced signal‐to‐noise ratio, but this was acceptable. The phosphocreatine (PCr) depletion caused by exercise at 0° knee angulation was significantly higher in both gastrocnemii than in the soleus (i.e. 64.8 ± 19.6% and 65.9 ± 23.6% in gastrocnemius lateralis and medialis versus 15.3 ± 8.4% in the soleus).Spiral‐encoded 31P–MRSI is a powerful tool for dynamic mapping of exercising muscle oxidative metabolism, including localized assessment of PCr concentrations, pH and maximal oxidative flux with high temporal and spatial resolution.

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Section: Introductionmentioning

confidence: 99%

Dynamic ³¹P–MRSI using spiral spectroscopic imaging can map mitochondrial capacity in muscles of the human calf during plantar flexion exercise at 7 T

et al. 2016

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“…Studies in non-pregnant individuals with diabetes mellitus have shown that the endothelial dysfunction of capillaries within skeletal muscles can cause an imbalance of oxygen delivery relative to oxygen extraction [8,20], reduced muscle perfusion and mitochondrial dysfunction [20]. In women with GDM, proteomic analysis in abdominal muscles collected at delivery also revealed reduced mitochondrial protein expression and alterations in Ca 2+ handling protein content [21].…”

Section: Introductionmentioning

confidence: 99%

Impairments in microvascular function and skeletal muscle oxygenation in women with gestational diabetes mellitus: links to cardiovascular disease risk factors

et al. 2016

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Aims/hypothesis Gestational diabetes mellitus (GDM) is a risk factor for the development of endothelial dysfunction and cardiovascular disease. However, in vivo microvascular endothelial function in GDM has not been investigated. This study aimed to examine, using near-infrared spectroscopy (NIRS), whether: (1) there are differences in microvascular reactivity and skeletal muscle oxygen consumption (mVat rest and during exercise between GDM and uncomplicated pregnancies; and (2) ) and blunted hyperaemia (ΔTSI 6.8 ± 2.9 vs 9.5 ± 3.4) compared with controls (p < 0.01). Despite similar handgrip strength in the GDM and control groups (29.1 ± 8.1 vs 26.2 ± 10.4 kg, respectively), during repeated forearm contractions, women with GDM presented a blunted TSI response (6.5 ± 3.9 vs 19.2 ± 10.9; p < 0.01) and a reduced capacity to maintain the predetermined handgrip (23.4 ± 2.9 vs 27.4 ± 3.8%, p < 0.05). NIRS indices correlated with PWV, 24 h BP and blood glucose concentration earlier in pregnancy (r = 0.40-0.60; p < 0.05). Conclusions/interpretation Women with GDM exhibited a characteristic blunted TSI curve, showing alterations in muscle oxygenation and microvascular responsiveness compared with women with uncomplicated pregnancies. These alterations were manifested during exercise and possibly contribute to the reduced exercise tolerance in GDM. NIRS indices correlated with macrovascular indices (arterial stiffness) and 24 h BP.

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“…The determination of resting muscle oxygen consumption using the venous occlusion method is suitable for clinical settings and allows non-invasive quantification of a compensatory peripheral adaptation in patients with PVD [44]. A review article evaluated the usefulness of 31 P-MRS and NIRS to determine mitochondrial function and the degree of ischaemia in type 2 diabetes mellitus and PVD, and found that the two measurements were well correlated for the assessment of mitochondrial function and the degree of ischaemia in these diseases (see [45] for review).…”

Section: (D) Examples Of Recent Advanced Near-infrared Spectroscopy Amentioning

confidence: 99%

“…Deoxy-Hb/Mb kinetics was measured in patients with type 2 diabetes mellitus at the onset of moderate cycling exercise (see [45,54] for review). The study found that type 2 diabetic skeletal muscle demonstrated a transient imbalance of muscle oxygen delivery relative to oxygen uptake, suggesting a slower muscle oxygen blood flow increase.…”

Section: (D) Examples Of Recent Advanced Near-infrared Spectroscopy Amentioning

confidence: 99%

The use of muscle near-infrared spectroscopy in sport, health and medical sciences: recent developments

Hamaoka

McCully

Niwayama

et al. 2011

Phil. Trans. R. Soc. A.

154

136

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Near-infrared spectroscopy (NIRS) has been shown to be one of the tools that can measure oxygenation in muscle and other tissues in vivo. This review paper highlights the progress, specifically in this decade, that has been made for evaluating skeletal muscle oxygenation and oxidative energy metabolism in sport, health and clinical sciences. Development of NIRS technologies has focused on improving quantification of the signal using multiple wavelengths to solve for absorption and scattering coefficients, multiple pathlengths to correct for the influence of superficial skin and fat, and time-resolved and phase-modulated light sources to determine optical pathlengths. In addition, advances in optical imaging with multiple source and detector pairs as well as portability using small wireless detectors have expanded the usefulness of the devices. NIRS measurements have provided information on oxidative metabolism in various athletes during localized exercise and whole-body exercise, as well as training-induced adaptations. Furthermore, NIRS technology has been used in the study of a number of chronic health conditions. Future developments of NIRS technology will include enhancing signal quantification. In addition, advances in NIRS imaging and portability promise to transform how measurements of oxygen utilization are obtained in the future.

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Muscle Mitochondrial Function in Patients with Type 2 Diabetes Mellitus and Peripheral Arterial Disease: Implications in Vascular Surgery

Cited by 33 publications

References 49 publications

Dynamic ³¹P–MRSI using spiral spectroscopic imaging can map mitochondrial capacity in muscles of the human calf during plantar flexion exercise at 7 T

Dynamic ³¹P–MRSI using spiral spectroscopic imaging can map mitochondrial capacity in muscles of the human calf during plantar flexion exercise at 7 T

Impairments in microvascular function and skeletal muscle oxygenation in women with gestational diabetes mellitus: links to cardiovascular disease risk factors

The use of muscle near-infrared spectroscopy in sport, health and medical sciences: recent developments

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Muscle Mitochondrial Function in Patients with Type 2 Diabetes Mellitus and Peripheral Arterial Disease: Implications in Vascular Surgery

Cited by 33 publications

References 49 publications

Dynamic 31P–MRSI using spiral spectroscopic imaging can map mitochondrial capacity in muscles of the human calf during plantar flexion exercise at 7 T

Dynamic 31P–MRSI using spiral spectroscopic imaging can map mitochondrial capacity in muscles of the human calf during plantar flexion exercise at 7 T

Impairments in microvascular function and skeletal muscle oxygenation in women with gestational diabetes mellitus: links to cardiovascular disease risk factors

The use of muscle near-infrared spectroscopy in sport, health and medical sciences: recent developments

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Product

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Dynamic ³¹P–MRSI using spiral spectroscopic imaging can map mitochondrial capacity in muscles of the human calf during plantar flexion exercise at 7 T

Dynamic ³¹P–MRSI using spiral spectroscopic imaging can map mitochondrial capacity in muscles of the human calf during plantar flexion exercise at 7 T