Muscle, myeloid cells, and complement: a complex interaction

Alexander, Jessy J.; Quigg, Richard J.

doi:10.1038/s41423-018-0049-4

Cited by 1 publication

(1 citation statement)

References 21 publications

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“…[4] Other transport modalities such as carrier-mediated transport channels, adsorption-mediated transcytosis, endocytosis, and receptor-mediated transcytosis could also play a critical role in BBB crossing. [5] In addition, it is noteworthy that since the tightly bounded astrocytic glia between the endothelial cells of brain capillaries are negatively charged, either positively charged or neutral pharmaceutical micro-masses could penetrate the BBB more easily. The BBB is not a passive protective barrier and not only allows the selective passage of a variety of nutrients needed for brain cell metabolism, but also diverts potentially toxic or harmful substances present or accumulating in the brain to the outside to maintain the stability of the microenvironment.…”

Section: Introductionmentioning

confidence: 99%

Intranasal Delivery of Functionalized Polymeric Nanomaterials to the Brain

Zha

Wong

All

2022

Adv Healthcare Materials

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Intravenous delivery of nanomaterials containing therapeutic agents and various cargos for treating neurological disorders is often constrained by low delivery efficacy due to difficulties in passing the blood-brain barrier (BBB). Nanoparticles (NPs) administered intranasally can move along olfactory and trigeminal nerves so that they do not need to pass through the BBB, allowing non-invasive, direct access to selective neural pathways within the brain. Hence, intranasal (IN) administration of NPs can effectively deliver drugs and genes into targeted regions of the brain, holding potential for efficacious disease treatment in the central nervous system (CNS). In this review, current methods for delivering conjugated NPs to the brain are primarily discussed. Distinctive potential mechanisms of therapeutic nanocomposites delivered via IN pathways to the brain are then discussed. Recent progress in developing functional NPs for applications in multimodal bioimaging, drug delivery, diagnostics, and therapeutics is also reviewed. This review is then concluded by discussing existing challenges, new directions, and future perspectives in IN delivery of nanomaterials.

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Section: Introductionmentioning

confidence: 99%