Muscle Progenitors Derived from Extraocular Muscles Express Higher Levels of Neurotrophins and their Receptors than other Cranial and Limb Muscles

Carrero-Rojas, Génova; Benítez‐Temiño, Beatriz; Pastor, Ángel M.; Carrizosa, María A. Davis‐López de

doi:10.3390/cells9030747

Cited by 16 publications

(13 citation statements)

References 58 publications

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“…In accordance, the present results show that p75 NTR levels are proportional to fatigue resistance. Indeed, p75 NTR is upregulated in EOM myogenic progenitor cells, in relation to higher proliferative and fusion rates and better regenerative properties ( Carrero-Rojas et al, 2020 ). Thus, p75 NTR seems to be related to selective muscle resistance.…”

Section: Discussionmentioning

confidence: 99%

TrkB signaling is correlated with muscular fatigue resistance and less vulnerability to neurodegeneration

Just-Borràs

Cilleros-Mañé²,

Полищук³

et al. 2022

Front. Mol. Neurosci.

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At the neuromuscular junction (NMJ), motor neurons and myocytes maintain a bidirectional communication that guarantees adequate functionality. Thus, motor neurons’ firing pattern, which is influenced by retrograde muscle-derived neurotrophic factors, modulates myocyte contractibility. Myocytes can be fast-twitch fibers and become easily fatigued or slow-twitch fibers and resistant to fatigue. Extraocular muscles (EOM) show mixed properties that guarantee fast contraction speed and resistance to fatigue and the degeneration caused by Amyotrophic lateral sclerosis (ALS) disease. The TrkB signaling is an activity-dependent pathway implicated in the NMJ well-functioning. Therefore, it could mediate the differences between fast and slow myocytes’ resistance to fatigue. The present study elucidates a specific protein expression profile concerning the TrkB signaling that correlates with higher resistance to fatigue and better neuroprotective capacity through time. The results unveil that Extra-ocular muscles (EOM) express lower levels of NT-4 that extend TrkB signaling, differential PKC expression, and a higher abundance of phosphorylated synaptic proteins that correlate with continuous neurotransmission requirements. Furthermore, common molecular features between EOM and slow soleus muscles including higher neurotrophic consumption and classic and novel PKC isoforms balance correlate with better preservation of these two muscles in ALS. Altogether, higher resistance of Soleus and EOM to fatigue and ALS seems to be associated with specific protein levels concerning the TrkB neurotrophic signaling.

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Section: Discussionmentioning

confidence: 99%

TrkB signaling is correlated with muscular fatigue resistance and less vulnerability to neurodegeneration

Just-Borràs

Cilleros-Mañé²,

Полищук³

et al. 2022

Front. Mol. Neurosci.

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“…Neurotrophins are important modulators of myogenic regeneration and act by promoting the proliferation of myoblasts, improving myogenic fusion rates and protecting myotubes from stress stimuli, including oxidative stress. As a result, these muscles are better protected against stress and sarcopenia [64].…”

Section: Ngfmentioning

confidence: 99%

Biological Aspects of Selected Myokines in Skeletal Muscle: Focus on Aging

Mancinelli

Checcaglini

Coscia

et al. 2021

IJMS

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In the last decade, clear evidence has emerged that the cellular components of skeletal muscle are important sites for the release of proteins and peptides called “myokines”, suggesting that skeletal muscle plays the role of a secretory organ. After their secretion by muscles, these factors serve many biological functions, including the exertion of complex autocrine, paracrine and/or endocrine effects. In sum, myokines affect complex multi-organ processes, such as skeletal muscle trophism, metabolism, angiogenesis and immunological response to different physiological (physical activity, aging, etc.) or pathological states (cachexia, dysmetabolic conditions, chronic inflammation, etc.). The aim of this review is to describe in detail a number of myokines that are, to varying degrees, involved in skeletal muscle aging processes and belong to the group of proteins present in the functional environment surrounding the muscle cell known as the “Niche”. The particular myokines described are those that, acting both from within the cell and in an autocrine manner, have a defined relationship with the modulation of oxidative stress in muscle cells (mature or stem) involved in the regulatory (metabolic or regenerative) processes of muscle aging. Myostatin, IGF-1, NGF, S100 and irisin are examples of specific myokines that have peculiar features in their mechanisms of action. In particular, the potential role of one of the most recently characterized myokines—irisin, directly linked to an active lifestyle—in reducing if not reversing senescence-induced oxidative damage is discussed in terms of its possible application as an agent able to counteract the deleterious effects of muscle aging.

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“…The transplantation of EOM MuSCs to the limb leads to more vigorous regeneration in the host muscles than in their limb donor counterparts ( Stuelsatz et al, 2015 ). Mechanistic studies indicated that the higher expression of trophic factors in EOM MuSCs, including brain-derived neurotrophic factors and nerve growth factors, may account for the enhanced myogenic activities ( Carrero-Rojas et al, 2020 ).…”

Section: The Architect Of Muscle Regeneration: Satellite Cellsmentioning

confidence: 99%

“…Both the craniofacial muscles and the trunk/limb muscles derive from the mesoderm (Diogo et al, 2015;Cao et al, 2019;Schubert et al, 2019), but there are many embryonic differences. The craniofacial muscles are derivatives of the cranial mesoderm, while the trunk/limb muscles are derivatives of the lateral plate mesoderm, leading to distinct developmental patterns and genetic lineages in the two muscle groups (Vyas et al, 2020).…”

Section: Craniofacial Muscs Are Of Diverse Embryonic Originsmentioning

confidence: 99%

Distinct Embryonic Origin and Injury Response of Resident Stem Cells in Craniofacial Muscles

Cheng

Shi

2021

Front. Physiol.

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Craniofacial muscles emerge as a developmental novelty during the evolution from invertebrates to vertebrates, facilitating diversified modes of predation, feeding and communication. In contrast to the well-studied limb muscles, knowledge about craniofacial muscle stem cell biology has only recently starts to be gathered. Craniofacial muscles are distinct from their counterparts in other regions in terms of both their embryonic origin and their injury response. Compared with somite-derived limb muscles, pharyngeal arch-derived craniofacial muscles demonstrate delayed myofiber reconstitution and prolonged fibrosis during repair. The regeneration of muscle is orchestrated by a blended source of stem/progenitor cells, including myogenic muscle satellite cells (MuSCs), mesenchymal fibro-adipogenic progenitors (FAPs) and other interstitial progenitors. Limb muscles host MuSCs of the Pax3 lineage, and FAPs from the mesoderm, while craniofacial muscles have MuSCs of the Mesp1 lineage and FAPs from the ectoderm-derived neural crest. Both in vivo and in vitro data revealed distinct patterns of proliferation and differentiation in these craniofacial muscle stem/progenitor cells. Additionally, the proportion of cells of different embryonic origins changes throughout postnatal development in the craniofacial muscles, creating a more dynamic niche environment than in other muscles. In-depth comparative studies of the stem cell biology of craniofacial and limb muscles might inspire the development of novel therapeutics to improve the management of myopathic diseases. Based on the most up-to-date literature, we delineated the pivotal cell populations regulating craniofacial muscle repair and identified clues that might elucidate the distinct embryonic origin and injury response in craniofacial muscle cells.

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Muscle Progenitors Derived from Extraocular Muscles Express Higher Levels of Neurotrophins and their Receptors than other Cranial and Limb Muscles

Cited by 16 publications

References 58 publications

TrkB signaling is correlated with muscular fatigue resistance and less vulnerability to neurodegeneration

TrkB signaling is correlated with muscular fatigue resistance and less vulnerability to neurodegeneration

Biological Aspects of Selected Myokines in Skeletal Muscle: Focus on Aging

Distinct Embryonic Origin and Injury Response of Resident Stem Cells in Craniofacial Muscles

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