Muscle rupture caused by exacerbated spasticity in a patient with multiple sclerosis

Patejdl, Robert; Winkelmann, Alexander; Zettl, Uwe K.

doi:10.1007/s00415-008-6021-y

Cited by 4 publications

(2 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…8 Besides economic factors, spasticity is a major cause of disease burden in MS patients, 2 which even may lead to muscle rupture. 18 We are aware of limitations to our results. Physical therapy will also lead to improvement of walking distance and spasticity, and will influence EDSS.…”

Section: Discussionmentioning

confidence: 88%

Effects of intrathecal triamincinolone-acetonide treatment in MS patients with therapy-resistant spasticity

et al. 2014

View full text Add to dashboard Cite

Objectives: Multiple sclerosis (MS) is an autoimmune disease affecting young people and is a major cause of disability. In the course of time, disability progresses and symptoms like spasticity may occur. Spasticity is a major cost factor in MS patients. Various agents are approved for the treatment of spasticity, but each of those agents may have several side effects. Intrathecally administered steroids (triamcinolone-acetonide (TCA)) may be efficient in treating spasticity in patients with lesions in the spinal cord and no response to first-line therapeutics. The aim of this study is to show effects of TCA treatment on clinical parameters in patients with MS. Methods: This multicentre open label study included 54 patients with MS. The clinical outcome parameters were spasticity, disability, maximum walking distance, bladder function and quality of life. All patients received physiotherapy in addition to TCA treatment to obtain optimal effects on clinical parameters. Results: Spasticity, maximum walking distance as well as disability improved significantly (Pp0.001) during TCA applications. Bladder function improved in every seventh patient. Conclusion: We observed the effects of intrathecally administered TCA on different clinical parameters including bladder function. TCA administration is a safe method to treat different symptoms in MS patients. Longitudinal trials with repeated TCA cycles are needed to show long-term effects. Besides TCA treatment, physiotherapy contributes to the improvement of clinical parameters.

show abstract

Section: Discussionmentioning

confidence: 88%

Effects of intrathecal triamincinolone-acetonide treatment in MS patients with therapy-resistant spasticity

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Two case reports of muscle rupture complication have been described; in a brain injury patient 1 and a MS patient. 2 In both cases, the patients had severe spasticity.…”

Section: Discussionmentioning

confidence: 93%

Muscle rupture after minimal trauma of the spastic muscle: three case reports of patients with spinal cord injury

2013

View full text Add to dashboard Cite

Study design: Retrospective study of three cases. Objectives: To report three cases of muscle rupture caused by minimal trauma in spinal cord injury (SCI) patients with severe spasticity and a literature review of the underlying mechanisms. Setting: Department of Physical and Rehabilitation Medicine, University Hospitals Leuven, Belgium Methods: Retrospective study of three cases of muscle ruptures in SCI patients with severe spasticity. All muscle lesions were diagnosed by ultrasound. Literature review (Pubmed) was performed to identify extrinsic and intrinsic risk factors. Results: According to the literature and our clinical findings, several structural and mechanical alterations of the spastic muscle in combination with specific stretching during therapy or a transfer can cause a muscle rupture after minimal trauma. Conclusion: To the authors' knowledge, this is the first report of muscle rupture due to spasticity in SCI patients. Altered mechanical properties of the spastic muscle in combination with extreme stretching may cause partial or complete ruptur. Although this is a rare complication of spasticity, medical staff and therapists should be aware of the risk factors in order to prevent and quickly identify muscle lesions.

show abstract

Medikamentöse Therapie spastischer Bewegungsstörungen

Patejdl¹,

Tesar²,

Zettl³

2012

DNP

View full text Add to dashboard Cite

Muscle rupture caused by exacerbated spasticity in a patient with multiple sclerosis

Cited by 4 publications

References 13 publications

Effects of intrathecal triamincinolone-acetonide treatment in MS patients with therapy-resistant spasticity

Effects of intrathecal triamincinolone-acetonide treatment in MS patients with therapy-resistant spasticity

Muscle rupture after minimal trauma of the spastic muscle: three case reports of patients with spinal cord injury

Medikamentöse Therapie spastischer Bewegungsstörungen

Contact Info

Product

Resources

About