Mushroom lectin overcomes hepatitis B virus tolerance via TLR6 signaling

He, Meina; Su, Dan; Liu, Q.; Gao, Wenjuan; Kang, Youmin

doi:10.1038/s41598-017-06261-5

Cited by 20 publications

(6 citation statements)

References 36 publications

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“…The in vivo immunomodulatory effects of lectin isolated from A. bisporus was also studied [190]. Lectin from P. ostreatus (POL) stimulated an immune response and has been considered as a potential therapeutic approach to break HBV tolerance [191]. It has also been shown to act as a food-intake-suppressing substance, which can help in weight reduction [192].…”

Section: Proteinsmentioning

confidence: 99%

Macrofungi as a Nutraceutical Source: Promising Bioactive Compounds and Market Value

Niego

Rapior

Thongklang

et al. 2021

JoF

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Macrofungi production and economic value have been increasing globally. The demand for macrofungi has expanded rapidly owing to their popularity among consumers, pleasant taste, and unique flavors. The presence of high quality proteins, polysaccharides, unsaturated fatty acids, minerals, triterpene sterols, and secondary metabolites makes macrofungi an important commodity. Macrofungi are well known for their ability to protect from or cure various health problems, such as immunodeficiency, cancer, inflammation, hypertension, hyperlipidemia, hypercholesterolemia, and obesity. Many studies have demonstrated their medicinal properties, supported by both in vivo and in vitro experimental studies, as well as clinical trials. Numerous bioactive compounds isolated from mushrooms, such as polysaccharides, proteins, fats, phenolic compounds, and vitamins, possess strong bioactivities. Consequently, they can be considered as an important source of nutraceuticals. Numerous edible mushrooms have been studied for their bioactivities, but only a few species have made it to the market. Many species remain to be explored. The converging trends and popularity of eastern herbal medicines, natural/organic food product preference, gut-healthy products, and positive outlook towards sports nutrition are supporting the growth in the medicinal mushroom market. The consumption of medicinal mushrooms as functional food or dietary supplement is expected to markedly increase in the future. The global medicinal mushroom market size is projected to increase by USD 13.88 billion from 2018 to 2022. The global market values of promising bioactive compounds, such as lentinan and lovastatin, are also expected to rise. With such a market growth, mushroom nutraceuticals hold to be very promising in the years to come.

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Section: Proteinsmentioning

confidence: 99%

Macrofungi as a Nutraceutical Source: Promising Bioactive Compounds and Market Value

Niego

Rapior

Thongklang

et al. 2021

JoF

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“…Regarding many fungal crude extracts and their enzymes, the antiviral effect of fungal lectin against HIV was the most investigated virus. El-Maradny et al [194] indicated that the purified Trichogin protein from Tricholoma giganteum was found to inhibit the HIV reverse transcriptase (RT) enzyme with the lowest IC 50 (half maximal inhibitory concentration) value determined to be 83 nM [195], followed by the purified lectin from Russula delica with IC 50 value of 0.26 [75] and the purified laccase from Tricholoma mongolicum with IC 50 value of 0.62 µM [196]. Lectins bind with viral envelope glycoproteins and inhibit the entry of many viruses, such as HIV, thus inhibiting virus attachment and blocking its entry via inducing the virus conformational rearrangements [197].…”

Section: Biomedical Applications 431 Antimicrobialmentioning

confidence: 99%

A Comprehensive Insight into Fungal Enzymes: Structure, Classification, and Their Role in Mankind’s Challenges

El‐Gendi

Saleh

Badierah

et al. 2021

JoF

120

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Enzymes have played a crucial role in mankind’s challenges to use different types of biological systems for a diversity of applications. They are proteins that break down and convert complicated compounds to produce simple products. Fungal enzymes are compatible, efficient, and proper products for many uses in medicinal requests, industrial processing, bioremediation purposes, and agricultural applications. Fungal enzymes have appropriate stability to give manufactured products suitable shelf life, affordable cost, and approved demands. Fungal enzymes have been used from ancient times to today in many industries, including baking, brewing, cheese making, antibiotics production, and commodities manufacturing, such as linen and leather. Furthermore, they also are used in other fields such as paper production, detergent, the textile industry, and in drinks and food technology in products manufacturing ranging from tea and coffee to fruit juice and wine. Recently, fungi have been used for the production of more than 50% of the needed enzymes. Fungi can produce different types of enzymes extracellularly, which gives a great chance for producing in large amounts with low cost and easy viability in purified forms using simple purification methods. In the present review, a comprehensive trial has been advanced to elaborate on the different types and structures of fungal enzymes as well as the current status of the uses of fungal enzymes in various applications.

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“…In an acute HBV replication mouse model, flagellin protein as a bacterial PAMP plays a pivotal role in regulating intrahepatic CD8 + T-cell responses by activating the TLR5 pathway (Yan et al, 2020). TLR6 overcome HBV tolerance in the CHB mouse models by enhancing HBV-specific antibody levels and follicular-assisted T-cell responses (He et al, 2017). This study proposes a novel mechanism by which TLR6 acts on the immune response and a therapeutic approach that breaks down the tolerance of HBV.…”

Section: Tlr Agonist-mediated Therapeutics For Controlling Hbv Replic...mentioning

confidence: 91%

Novel Molecular Therapeutics Targeting Signaling Pathway to Control Hepatitis B Viral Infection

Yan

Qiu

Davgadorj

et al. 2022

Front. Cell. Infect. Microbiol.

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Numerous canonical cellular signaling pathways modulate hepatitis B virus (HBV) replication. HBV genome products are known to play a significant role in regulating these cellular pathways for the liver’s viral-related pathology and physiology and have been identified as the main factor in hepatocarcinogenesis. Signaling changes during viral replication ultimately affect cellular persistence, multiplication, migration, genome instability, and genome damage, leading to proliferation, evasion of apoptosis, block of differentiation, and immortality. Recent studies have documented that numerous signaling pathway agonists or inhibitors play an important role in reducing HBV replication in vitro and in vivo, and some have been used in phase I or phase II clinical trials. These optional agents as molecular therapeutics target cellular pathways that could limit the replication and transcription of HBV or inhibit the secretion of the small surface antigen of HBV in a signaling-independent manner. As principle-based available information, a combined strategy including antiviral therapy and immunomodulation will be needed to control HBV infection effectively. In this review, we summarize recent findings on interventions of molecular regulators in viral replication and the interactions of HBV proteins with the components of the various targeting cellular pathways, which may assist in designing novel agents to modulate signaling pathways to prevent HBV replication or carcinogenesis.

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Mushroom lectin overcomes hepatitis B virus tolerance via TLR6 signaling

Cited by 20 publications

References 36 publications

Macrofungi as a Nutraceutical Source: Promising Bioactive Compounds and Market Value

Macrofungi as a Nutraceutical Source: Promising Bioactive Compounds and Market Value

A Comprehensive Insight into Fungal Enzymes: Structure, Classification, and Their Role in Mankind’s Challenges

Novel Molecular Therapeutics Targeting Signaling Pathway to Control Hepatitis B Viral Infection

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