Mussel-inspired injectable chitosan hydrogel modified with catechol for cell adhesion and cartilage defect repair

Zhou, Siqi; Bei, Zhongwu; Wei, Jian; Yan, Xinxin; Wen, Haiyan; Cao, Yiping; Li, Haohuan

doi:10.1039/d1tb02241e

Cited by 35 publications

(23 citation statements)

References 41 publications

(36 reference statements)

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“…Considering the risk of byproduct toxicity, emerging cross-linking strategies involve enzymatic reactions [ 181 ]. Siqi Zhou et al [ 182 ] reported on the functionalization of CHT with 3,4-dihydroxyhydrocinnamic acid, followed by oxidative cross-linking through horseradish peroxidase/hydrogen peroxide (HRP/H 2 O 2 ) ( Scheme 10 ).…”

Section: Chitosan-based Hydrogels For Biomedical Applicationsmentioning

confidence: 99%

Chitosan-Based Biomaterials: Insights into Chemistry, Properties, Devices, and Their Biomedical Applications

et al. 2023

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Chitosan is a marine-origin polysaccharide obtained from the deacetylation of chitin, the main component of crustaceans’ exoskeleton, and the second most abundant in nature. Although this biopolymer has received limited attention for several decades right after its discovery, since the new millennium chitosan has emerged owing to its physicochemical, structural and biological properties, multifunctionalities and applications in several sectors. This review aims at providing an overview of chitosan properties, chemical functionalization, and the innovative biomaterials obtained thereof. Firstly, the chemical functionalization of chitosan backbone in the amino and hydroxyl groups will be addressed. Then, the review will focus on the bottom-up strategies to process a wide array of chitosan-based biomaterials. In particular, the preparation of chitosan-based hydrogels, organic–inorganic hybrids, layer-by-layer assemblies, (bio)inks and their use in the biomedical field will be covered aiming to elucidate and inspire the community to keep on exploring the unique features and properties imparted by chitosan to develop advanced biomedical devices. Given the wide body of literature that has appeared in past years, this review is far from being exhaustive. Selected works in the last 10 years will be considered.

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Section: Chitosan-based Hydrogels For Biomedical Applicationsmentioning

confidence: 99%

Chitosan-Based Biomaterials: Insights into Chemistry, Properties, Devices, and Their Biomedical Applications

et al. 2023

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“…[31a,164] These materials include films, [165] particles, [142] fibers, [139,166] foams, [167] and hydrogels. [141,168] It has been extensively used in the biomedical field because of its biodegradability and biocompatibility.…”

Section: Chitin and Chitosanmentioning

confidence: 99%

Nature‐Inspired Strategies for the Treatment of Osteoarthritis

Wu,

Zheng,

et al. 2023

Adv Funct Materials

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Articular cartilage is devoid of nerves and blood vessels, and its nutrients must be obtained from the joint fluid; therefore, its ability to repair itself is limited. Manufactured materials such as artificial cartilage or synthetic materials are typically used in traditional approaches for knee cartilage repair. However, durability, postimplant rejection, and tissue incompatibility are the problems associated with these materials. In recent decades, tissue engineering and regenerative medicine have focused on the development of functional substitutes, particularly those based on naturally inspired biopolymers. This review focuses on sustainably produced biopolymers based on materials derived from natural sources. Furthermore, these materials have many advantages, including low antigenicity, biocompatibility, and degradability. Of course, there are also many challenges associated with natural materials, such as the lack of clinical studies and long‐term follow‐up data, unstable mechanical properties of the materials, and high demands placed on preparation and molding techniques. In this review, an overview of natural and nature‐inspired polymers that are the subject of research to date, as well as their structural designs and product performances is provided. This review provides scientific guidance for enhancing the development of naturally inspired materials for treating cartilage injuries.

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“…With the increase of amplification generations, chondrocytes lose their chondrogenic phenotype. Eventually, this results in lower cartilage repair ( Cai et al, 2020 ; Zhou et al, 2022 ). Autologous chondrocytes are mainly derived from natural cartilage in the non-weight-bearing region of the joint, which may lead to donor site disease ( Chen et al, 2018 ).…”

Section: Materials Of Injectable Hydrogelsmentioning

confidence: 99%

Advanced injectable hydrogels for cartilage tissue engineering

Zhu

et al. 2022

Front. Bioeng. Biotechnol.

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The rapid development of tissue engineering makes it an effective strategy for repairing cartilage defects. The significant advantages of injectable hydrogels for cartilage injury include the properties of natural extracellular matrix (ECM), good biocompatibility, and strong plasticity to adapt to irregular cartilage defect surfaces. These inherent properties make injectable hydrogels a promising tool for cartilage tissue engineering. This paper reviews the research progress on advanced injectable hydrogels. The cross-linking method and structure of injectable hydrogels are thoroughly discussed. Furthermore, polymers, cells, and stimulators commonly used in the preparation of injectable hydrogels are thoroughly reviewed. Finally, we summarize the research progress of the latest advanced hydrogels for cartilage repair and the future challenges for injectable hydrogels.

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Mussel-inspired injectable chitosan hydrogel modified with catechol for cell adhesion and cartilage defect repair

Abstract: Repairing articular cartilage defect is a great challenge due to the poor self-regenerative capability of cartilage. Hydrogel-based tissue engineering has been considered as an effective strategy. In this study, inspired...

Cited by 35 publications

References 41 publications

Chitosan-Based Biomaterials: Insights into Chemistry, Properties, Devices, and Their Biomedical Applications

Chitosan-Based Biomaterials: Insights into Chemistry, Properties, Devices, and Their Biomedical Applications

Nature‐Inspired Strategies for the Treatment of Osteoarthritis

Advanced injectable hydrogels for cartilage tissue engineering

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