Mutagenic effect of epichlorohydrin II. Analysis of chromosomal aberrations in lymphocytes of persons occupationally exposed to epichlorohydrin

Low Epichlorohydrin Concentrations Induce Sister Chromatid Exchanges in Human Lymphocytes «in Vitro»

“…Mutagenic effects of ECHH in human lymphocytes «in vitro» SRAM et al 1976) and «in vivo» (exposed workers) KucEROVA et al 1977;PICCIANO 1979) have been exhaustively demonstrated by analysing chromosome aberrations. The increase of chromosome aberrations is dose-dependent in human lymphocytes exposed to ECHH « in vitro » (Ku-CEROVA et al 1976).…”

Potential carcinogenic and mutagenic industrial chemicals. I. Alkylating agents

“…A prospective cytogenetic study of 35 workers occupationally exposed to epichlorohydrin in Czechoslovakia (Kucerova et al, 1977) disclosed that the percentage of cells with chromosomal aberrations in peripheral lymphocytes was 1.37 before exposure, 1.91 after the first year of exposure, and 2.69 after the second year. Of particular significance was the increase of chromatid and chromosome breaks after exposure concurrent with an increased number of breaks per 100 cells.…”

Short-Term Bioassays in the Analysis of Complex Environmental Mixtures III

“…Among these compounds, 5 in the first group: arsenic (Beckman et al, 1979;Nordenson et al, 1978), benzene (Tough et a1., 1970;Picciano et al, 1979), bis (chloromethyl) ether and chloromethyl methyl ether (Zundova and Landa, 1979), and vinyl chloride (Funes-Cravioto et al, 1975;Ducatman et al, 1975) have been evaluated for their ability to produce chromosome damage in man, and were found positive. Similarly, 3/3 compounds tested in the second category: cyclophosphamide (Etteldorf et al, 1976), epichlorohydrin (Kucerova et al, 1977;Picciano, 1979), and thiotepa (Si1ezneva and Korman, 1973) have been checked and shown to cause chromosome damage in man. In the third category, 4/4 compounds tested: chloroprene (Katosova, 1973;Sanotskii, 1976), ethylene oxide (Garry et a1., 1979), lead (Forni and Secci, 1972;Garza-Chapa et a1., 1977), and styrene (Meretoja et a1., 1977) caused chromosome damage in man.…”